Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Bruno Botta"'
Autor:
María Balsera-Manzanero, Francesca Ghirga, Ana Ruiz-Molina, Mattia Mori, Jerónimo Pachón, Bruno Botta, Elisa Cordero, Deborah Quaglio, Javier Sánchez-Céspedes
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Regardless of the clinical impact of human adenovirus (HAdV) infections in the healthy population and its high morbidity in immunosuppressed patients, a specific treatment is still not yet available. In this study, we screened the CM1407 COST Action
Externí odkaz:
https://doaj.org/article/16017175d6df4b659d48d030b5b66d11
Autor:
Mattia Mori, Francesca Ghirga, Beatrice Amato, Luca Secco, Deborah Quaglio, Isabella Romeo, Marta Gambirasi, Alberta Bergamo, Sonia Covaceuszach, Riccardo Sgarra, Bruno Botta, Guidalberto Manfioletti
Publikováno v:
ACS Omega, Vol 8, Iss 36, Pp 32424-32431 (2023)
Externí odkaz:
https://doaj.org/article/53d81a7b3be24d8483ab60c73cf116db
Autor:
Rie Nygaard, Chris L. B. Graham, Meagan Belcher Dufrisne, Jonathan D. Colburn, Joseph Pepe, Molly A. Hydorn, Silvia Corradi, Chelsea M. Brown, Khuram U. Ashraf, Owen N. Vickery, Nicholas S. Briggs, John J. Deering, Brian Kloss, Bruno Botta, Oliver B. Clarke, Linda Columbus, Jonathan Dworkin, Phillip J. Stansfeld, David I. Roper, Filippo Mancia
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Peptidoglycan (PG) is an essential structural component of the bacterial cell wall that is synthetized during cell division and elongation. PG forms an extracellular polymer crucial for cellular viability, the synthesis of which is the targe
Externí odkaz:
https://doaj.org/article/f8db36713a734cacbd61374a4c829bb4
Autor:
Vladimir Perovic, Kristina Stevanovic, Natalya Bukreyeva, Slobodan Paessler, Junki Maruyama, Sergi López-Serrano, Ayub Darji, Milan Sencanski, Draginja Radosevic, Simone Berardozzi, Bruno Botta, Mattia Mori, Sanja Glisic
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4911 (2024)
The influenza A virus nonstructural protein 1 (NS1), which is crucial for viral replication and immune evasion, has been identified as a significant drug target with substantial potential to contribute to the fight against influenza. The emergence of
Externí odkaz:
https://doaj.org/article/9eea7d0871e047f4a013bed4a1c970c9
Autor:
Francesca Romana Liberati, Sara Di Russo, Lorenzo Barolo, Giovanna Peruzzi, Maria Vittoria Farina, Sharon Spizzichino, Federica Di Fonzo, Deborah Quaglio, Luca Pisano, Bruno Botta, Alessandra Giorgi, Alberto Boffi, Francesca Cutruzzolà, Alessio Paone, Paola Baiocco
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 402 (2024)
Chronic lymphocytic leukemia (CLL) is a widespread type of leukemia that predominantly targets B lymphocytes, undermining the balance between cell proliferation and apoptosis. In healthy B cells, miR-15/16, a tandem of microRNAs, functions as a tumor
Externí odkaz:
https://doaj.org/article/c3cb26ae36b04029a7e08117175fdbb3
Autor:
Alessandro Falsini, Gaia Giuntini, Mattia Mori, Francesca Ghirga, Deborah Quaglio, Antonino Cucinotta, Federica Coppola, Irene Filippi, Antonella Naldini, Bruno Botta, Fabio Carraro
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 227 (2024)
Melanoma is the principal cause of death in skin cancer due to its ability to invade and cause metastasis. Hypoxia, which characterises the tumour microenvironment (TME), plays an important role in melanoma development, as cancer cells can adapt and
Externí odkaz:
https://doaj.org/article/3cbc55a18b1a4bdab49b40f3076dabf2
Autor:
Alessandro Soloperto, Deborah Quaglio, Paola Baiocco, Isabella Romeo, Mattia Mori, Matteo Ardini, Caterina Presutti, Ida Sannino, Silvia Ghirga, Antonia Iazzetti, Rodolfo Ippoliti, Giancarlo Ruocco, Bruno Botta, Francesca Ghirga, Silvia Di Angelantonio, Alberto Boffi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Numerous studies have shown a strong correlation between the number of neurofibrillary tangles of the tau protein and Alzheimer's disease progression, making the quantitative detection of tau very promising from a clinical point of view. How
Externí odkaz:
https://doaj.org/article/ea4bc56ead7f4f7b80769aef5c5bb896
Autor:
Luca Cassetta, Pedro Rodrigues, Toni Andreu, Bruno Botta, Sven Brandau, Chrissie Brierley, Clive Wilson, Inga Dadeshidze, Lucia Forzi, Federica Ortelli, Mafalda Quintas
Publikováno v:
Research Ideas and Outcomes, Vol 6, Iss , Pp 1-15 (2020)
Cancer has been for many years the second leading cause of mortality right after cardiovascular diseases, representing 25% of all the deaths reported yearly and this tendency is expected to increase. Although the recent public health emergency caused
Externí odkaz:
https://doaj.org/article/90e7161754c7411d8286d87b2c5eca7c
Autor:
Chiara Platella, Francesca Ghirga, Domenica Musumeci, Deborah Quaglio, Pasquale Zizza, Sara Iachettini, Carmen D’Angelo, Annamaria Biroccio, Bruno Botta, Mattia Mori, Daniela Montesarchio
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4070 (2023)
Aiming to identify highly effective and selective G-quadruplex ligands as anticancer candidates, five natural compounds were investigated here, i.e., the alkaloids Canadine, D-Glaucine and Dicentrine, as well as the flavonoids Deguelin and Millettone
Externí odkaz:
https://doaj.org/article/f256c704cf9a4f91838f48adb6fb81fd
Autor:
Mattia Mori, Deborah Quaglio, Andrea Calcaterra, Francesca Ghirga, Leonardo Sorrentino, Silvia Cammarone, Matteo Fracella, Alessandra D’Auria, Federica Frasca, Elena Criscuolo, Nicola Clementi, Nicasio Mancini, Bruno Botta, Guido Antonelli, Alessandra Pierangeli, Carolina Scagnolari
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 314 (2023)
The SARS-CoV-2 protease (3CLpro) is one of the key targets for the development of efficacious drugs for COVID-19 treatment due to its essential role in the life cycle of the virus and exhibits high conservation among coronaviruses. Recent studies hav
Externí odkaz:
https://doaj.org/article/48e97d7052a84ed3a6b6f9f38b779a5b