Global O-GlcNAcylation changes impact desmin phosphorylation and its partition toward cytoskeleton in C2C12 skeletal muscle cells differentiated into myotubes

Autor: Charlotte Claeyssen, Bruno Bastide, Caroline Cieniewski-Bernard

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Desmin is the guardian of striated muscle integrity, permitting the maintenance of muscle shape and the efficiency of contractile activity. It is also a key mediator of cell homeostasis and survival. To ensure the fine regulation of skeletal

Externí odkaz: https://doaj.org/article/c18de57563344666bdd35f9416d1b845

Sepsis-like Energy Deficit Is Not Sufficient to Induce Early Muscle Fiber Atrophy and Mitochondrial Dysfunction in a Murine Sepsis Model

Autor: Alexandre Pierre, Claire Bourel, Raphael Favory, Benoit Brassart, Frederic Wallet, Frederic N. Daussin, Sylvain Normandin, Michael Howsam, Raphael Romien, Jeremy Lemaire, Gaelle Grolaux, Arthur Durand, Marie Frimat, Bruno Bastide, Philippe Amouyel, Eric Boulanger, Sebastien Preau, Steve Lancel

Publikováno v: Biology, Vol 12, Iss 4, p 529 (2023)

Sepsis-induced myopathy is characterized by muscle fiber atrophy, mitochondrial dysfunction, and worsened outcomes. Whether whole-body energy deficit participates in the early alteration of skeletal muscle metabolism has never been investigated. Thre

Externí odkaz: https://doaj.org/article/3407fb141ccc48ac80753aa0c71a3049

Mild Intrauterine Hypoperfusion Leads to Lumbar and Cortical Hyperexcitability, Spasticity, and Muscle Dysfunctions in Rats: Implications for Prematurity

Autor: Jacques-Olivier Coq, Maxime Delcour, Yuko Ogawa, Julie Peyronnet, Francis Castets, Nathalie Turle-Lorenzo, Valérie Montel, Laurence Bodineau, Phillipe Cardot, Cécile Brocard, Sylvie Liabeuf, Bruno Bastide, Marie-Hélène Canu, Masahiro Tsuji, Florence Cayetanot

Publikováno v: Frontiers in Neurology, Vol 9 (2018)

Intrauterine ischemia-hypoxia is detrimental to the developing brain and leads to white matter injury (WMI), encephalopathy of prematurity (EP), and often to cerebral palsy (CP), but the related pathophysiological mechanisms remain unclear. In prior

Externí odkaz: https://doaj.org/article/d37957c4a8404178881e322be45acbd3

Increasing O-GlcNAcylation level on organ culture of soleus modulates the calcium activation parameters of muscle fibers.

Autor: Caroline Cieniewski-Bernard, Valerie Montel, Serge Berthoin, Bruno Bastide

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e48218 (2012)

O-N-acetylglucosaminylation is a reversible post-translational modification which presents a dynamic and highly regulated interplay with phosphorylation. New insights suggest that O-GlcNAcylation might be involved in striated muscle physiology, in pa

Externí odkaz: https://doaj.org/article/798db329980c49079c9320dc73690afd

Early movement restriction deteriorates motor function and soleus muscle physiology

Autor: Julie Dereumetz, Patrick Decherchi, Erwan Dupont, Valérie Montel, Marie-Hélène Canu, Jacques-Olivier Coq, Tanguy Marqueste, Bruno Bastide

Publikováno v: Experimental Neurology
Experimental Neurology, Elsevier, 2022, 347, pp.113886. ⟨10.1016/j.expneurol.2021.113886⟩
Experimental Neurology, 2021, 347, ⟨10.1016/j.expneurol.2021.113886⟩
Experimental Neurology, 2022, 347, pp.113886. ⟨10.1016/j.expneurol.2021.113886⟩

International audience; Children with low physical activity and interactions with environment experience atypical sensorimotor development and maturation leading to anatomical and functional disorganization of the sensorimotor circuitry and also to e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520b5049649b64b0248933e1e612dba0
https://hal.archives-ouvertes.fr/hal-03419896