Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study

Autor: Victor Kande Betu Ku Mesu, DPH, Wilfried Mutombo Kalonji, MD, Clélia Bardonneau, MSc, Olaf Valverde Mordt, MSc, Digas Ngolo Tete, MPH, Séverine Blesson, MSc, François Simon, MSc, Sophie Delhomme, MSc, Sonja Bernhard, PhD, Hélène Mahenzi Mbembo, MD, Christian Mpia Moke, MD, Steven Lumeya Vuvu, MMed, Junior Mudji E'kitiak, MD, Felix Akwaso Masa, MD, Melchias Mukendi Ilunga, MD, Dieudonné Mpoyi Muamba Nzambi, MD, Tim Mayala Malu, MD, Serge Kapongo Tshilumbwa, MD, Franck Botalema Bolengi, MD, Mathieu Nkieri Matsho, MD, Crispin Lumbala, MPH, Bruno Scherrer, PhD, Nathalie Strub-Wourgaft, MD, Antoine Tarral, MD

Publikováno v: The Lancet Global Health, Vol 9, Iss 7, Pp e999-e1008 (2021)

Summary: Background: Staging and treatment of human African trypanosomiasis caused by Trypanosoma brucei gambiense (g-HAT) required lumbar puncture to assess cerebrospinal fluid (CSF) and intravenous drugs that cross the blood–brain barrier for lat

Externí odkaz: https://doaj.org/article/fc53e144d24e4957ad24602246c04574

Sodium Oxybate for Alcohol Dependence: A Network Meta-Regression Analysis Considering Population Severity at Baseline and Treatment Duration

Autor: Julien Guiraud, Giovanni Addolorato, Henri-Jean Aubin, Sylvie Bachelot, Philippe Batel, Andrea de Bejczy, Amine Benyamina, Fabio Caputo, Monique Couderc, Maurice Dematteis, Anna E Goudriaan, Antoni Gual, Sylvie Lecoustey, Otto-Michael Lesch, Icro Maremmani, David J Nutt, François Paille, Pascal Perney, Jürgen Rehm, Benjamin Rolland, Bruno Scherrer, Nicolas Simon, Bo Söderpalm, Lorenzo Somaini, Wolfgang H Sommer, Rainer Spanagel, Henriette Walter, Wim van den Brink

Publikováno v: Alcohol and Alcoholism
Alcohol and Alcoholism, 2023, 58 (2), pp.125-133. ⟨10.1093/alcalc/agac070⟩

AimsThe estimated effect of sodium oxybate (SMO) in the treatment of alcohol dependence is heterogeneous. Population severity and treatment duration have been identified as potential effect modifiers. Population severity distinguishes heavy drinking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d215cafecb878aac246497ae7f1561d7
https://pubmed.ncbi.nlm.nih.gov/36617267

The effects on ovarian activity of delaying versus immediately restarting combined oral contraception after missing three pills and taking ulipristal acetate 30 mg

Autor: Pascale Borenzstein, Christine Klipping, Camille Banh, Ingrid Duijkers, Delphine Levy-Gompel, Bruno Scherrer, Anna Glasier, Catherine Monteil, Tanja Rautenberg

Publikováno v: Contraception. 102:145-151

Objective Among combined oral contraception (COC) users, to determine the effect on ovarian activity and ovulation of waiting five days before restarting COC, versus restarting immediately, having taken ulipristal acetate 30 mg (UPA, the dose used fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379b167e3c1aab2036b5ec26a1c728a5
https://doi.org/10.1016/j.contraception.2020.05.013

Baseline severity and the prediction of placebo response in clinical trials for alcohol dependence: A meta-regression analysis to develop an enrichment strategy

Autor: Rainer Spanagel, Maurice Dematteis, Nicolas Simon, Otto-Michael Lesch, Bo Söderpalm, François Paille, Amine Benyamina, Giovanni Addolorato, Jürgen Rehm, Henri-Jean Aubin, Wim van den Brink, Roch Poulnais, Anna E. Goudriaan, Icro Maremmani, Bruno Scherrer, Fabio Caputo, Antoni Gual, Pascal Perney, Henriette Walter, Quentin Raffaillac, Lorenzo Leggio, Wolfgang H. Sommer, David J. Nutt, Julien Guiraud, Andrea de Bejczy, Benjamin Rolland, Falk Kiefer

Publikováno v: Alcoholism: Clinical and Experimental Research
Alcoholism: Clinical and Experimental Research, Wiley, 2021, 45 (9), pp.1722-1734. ⟨10.1111/acer.14670⟩
Alcoholism: Clinical and Experimental Research, 2021, 45 (9), pp.1722-1734. ⟨10.1111/acer.14670⟩
Alcoholism, clinical and experimental research, 45(9), 1722-1734. Wiley-Blackwell

International audience; Background: There is considerable unexplained variability in alcohol abstinence rates (AR) in the placebo groups of randomized controlled trials (RCTs) for alcohol dependence (AD). This is of particular interest because placeb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2c1ccec9079b7c919a2d25df134935
https://pubmed.ncbi.nlm.nih.gov/34418121

Safety and efficacy of oral fexinidazole in children with gambiense human African trypanosomiasis: a multicentre, single-arm, open-label, phase 2-3 trial

Autor: Victor Kande Betu Kumesu, Wilfried Mutombo Kalonji, Clélia Bardonneau, Olaf Valverde Mordt, Digas Ngolo Tete, Séverine Blesson, François Simon, Sophie Delhomme, Sonja Bernhard, Pathou Nganzobo Ngima, Hélène Mahenzi Mbembo, Jean-Pierre Fina Lubaki, Steven Lumeya Vuvu, Willy Kuziena Mindele, Médard Ilunga Wa Kyhi, Guylain Mandula Mokenge, Lewis Kaninda Badibabi, Augustin Kasongo Bonama, Papy Kavunga Lukula, Crispin Lumbala, Bruno Scherrer, Nathalie Strub-Wourgaft, Antoine Tarral

Publikováno v: The Lancet. Global health. 10(11)

BACKGROUND: Fexinidazole has been reported as an effective oral monotherapy against non-severe gambiense human African trypanosomiasis in a recent trial in adults. We aimed to assess the safety and efficacy of fexinidazole in children across all dise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9113a815c8f4ec01f0b6156728eb2c28
https://pubmed.ncbi.nlm.nih.gov/36179736