Zobrazeno 1 - 10
of 317
pro vyhledávání: '"Bruno, Quesnel"'
Autor:
Mélanie Lambert, Samy Jambon, Mohamed A. Bouhlel, Sabine Depauw, Julie Vrevin, Samuel Blanck, Guillemette Marot, Martin Figeac, Claude Preudhomme, Bruno Quesnel, David W. Boykin, Marie‐Hélène David‐Cordonnier
Publikováno v:
HemaSphere, Vol 8, Iss 5, Pp n/a-n/a (2024)
Abstract The mainstay of acute myeloid leukemia (AML) treatment still relies on traditional chemotherapy, with a survival rate of approximately 30% for patients under 65 years of age and as low as 5% for those beyond. This unfavorable prognosis prima
Externí odkaz:
https://doaj.org/article/a3c13963554d4ef19b2516b082160eb0
Autor:
Lama Hasan Bou Issa, Léa Fléchon, William Laine, Aicha Ouelkdite, Silvia Gaggero, Adeline Cozzani, Remi Tilmont, Paul Chauvet, Nicolas Gower, Romanos Sklavenitis-Pistofidis, Carine Brinster, Xavier Thuru, Yasmine Touil, Bruno Quesnel, Suman Mitra, Irene M. Ghobrial, Jérôme Kluza, Salomon Manier
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109417- (2024)
Summary: Multiple myeloma (MM) is an incurable hematological malignancy in which MYC alterations contribute to the malignant phenotype. Nevertheless, MYC lacks therapeutic druggability. Here, we leveraged large-scale loss-of-function screens and cond
Externí odkaz:
https://doaj.org/article/72ba85726c1743d3bf9ab81236b28b94
Autor:
Guillaume Escure, Elise Fournier, Cynthia Saade, Lama Hasan Bou Issa, Inès Arib, Rémi Tilmont, Nicolas Gazeau, Binta M. Thiam, Morgane Chovet, Maxime Delforge, Nicolas Gower, Léa Fléchon, Doriane Cavalieri, Paul Chauvet, Morgane Nudel, Laure Goursaud, Céline Berthon, Bruno Quesnel, Thierry Facon, Claude Preudhomme, Nicolas Duployez, Salomon Manier
Publikováno v:
Haematologica, Vol 109, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/a2a5f90de1ed463a8a881841c3ce5223
Autor:
Valerio Farfariello, Dmitri V. Gordienko, Lina Mesilmany, Yasmine Touil, Emmanuelle Germain, Ingrid Fliniaux, Emilie Desruelles, Dimitra Gkika, Morad Roudbaraki, George Shapovalov, Lucile Noyer, Mathilde Lebas, Laurent Allart, Nathalie Zienthal-Gelus, Oksana Iamshanova, Franck Bonardi, Martin Figeac, William Laine, Jerome Kluza, Philippe Marchetti, Bruno Quesnel, Daniel Metzger, David Bernard, Jan B. Parys, Loïc Lemonnier, Natalia Prevarskaya
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Mitochondrial Ca2+ homeostasis is reported to influence cellular senescence. Here the authors show that TRPC3 limits senescence by inhibiting IP3R-mediated Ca2+ release and ER mitochondria Ca2+ transfer and that the downregulation of TRPC3 in stromal
Externí odkaz:
https://doaj.org/article/18e1a197a54f4fbebb56df91fdd44151
Autor:
Stéphane deBotton, Joseph M. Brandwein, Andrew H. Wei, Arnaud Pigneux, Bruno Quesnel, Xavier Thomas, Ollivier Legrand, Christian Recher, Sylvain Chantepie, Mathilde Hunault‐Berger, Nicolas Boissel, Salem A. Nehme, Mark G. Frattini, Alessandra Tosolini, Roland Marion‐Gallois, Jixian J. Wang, Chris Cameron, Muhaimen Siddiqui, Brian Hutton, Gary Milkovich, Eytan M. Stein
Publikováno v:
Cancer Medicine, Vol 10, Iss 18, Pp 6336-6343 (2021)
Abstract Background The present study evaluated the relative survival benefits associated with enasidenib and current standard of care (SoC) therapies for patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) and an isocitrate dehydrog
Externí odkaz:
https://doaj.org/article/a8b6b60e03224a14a77e3d31e872ffc8
Autor:
Sylvie Galiègue‐Zouitina, Qiangwei Fu, Céline Carton‐Latreche, Nicolas Poret, Meyling Cheok, Frédéric Leprêtre, Martin Figeac, Bruno Quesnel, Hassiba El Bouazzati, Carl S Shelley
Publikováno v:
eJHaem, Vol 2, Iss 2, Pp 196-210 (2021)
Abstract RhoH is an unusual member of the Rho family of small GTP‐binding proteins in that it lacks GTPase activity. Since the RhoH protein is constantly bound by GTP, it is constitutively active and controlled predominantly by changes in quantitat
Externí odkaz:
https://doaj.org/article/d9fa8181839449a0b718389d9f9b0f02
Autor:
Alexia Mopin, Frédéric Leprêtre, Shéhérazade Sebda, Céline Villenet, Meriem Ben Khoud, Martin Figeac, Bruno Quesnel, Carine Brinster
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0267508 (2022)
Acute myeloid leukemia (AML) is characterized by blocked differentiation and extensive proliferation of hematopoietic progenitors/precursors. Relapse is often observed after chemotherapy due to the presence of residual leukemic cells, which is also c
Externí odkaz:
https://doaj.org/article/31962ed8d7c4476a99e37f9943419067
Autor:
Anne Trinh, Raeeka Khamari, Quentin Fovez, François-Xavier Mahon, Béatrice Turcq, Didier Bouscary, Patrice Maboudou, Marie Joncquel, Valérie Coiteux, Nicolas Germain, William Laine, Salim Dekiouk, Sandrine Jean-Pierre, Veronique Maguer-Satta, Bart Ghesquiere, Thierry Idziorek, Bruno Quesnel, Jerome Kluza, Philippe Marchetti
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101410- (2022)
Objective: Long-term treatment with tyrosine kinase inhibitors (TKI) represents an effective cure for chronic myeloid leukemia (CML) patients and discontinuation of TKI therapy is now proposed to patient with deep molecular responses. However, eviden
Externí odkaz:
https://doaj.org/article/bffd69c235194487adfbf1e0576e3453
Publikováno v:
Journal of Interferon & Cytokine Research. 43:164-172
Autor:
Xavier Thuru, Romain Magnez, Hassiba El-Bouazzati, Gérard Vergoten, Bruno Quesnel, Christian Bailly
Publikováno v:
Cancers, Vol 14, Iss 14, p 3368 (2022)
Monoclonal antibodies targeting the PD-1/PD-L1 immune checkpoint have considerably improved the treatment of some cancers, but novel drugs, new combinations, and treatment modalities are needed to reinvigorate immunosurveillance in immune-refractory
Externí odkaz:
https://doaj.org/article/da53f976355f45a0aa7a89f4c331bd7e