Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Bruno, Linclau"'
Autor:
Kristian Hollingsworth, Antonio Di Maio, Sarah-Jane Richards, Jean-Baptiste Vendeville, David E. Wheatley, Claire E. Council, Tessa Keenan, Hélène Ledru, Harriet Chidwick, Kun Huang, Fabio Parmeggiani, Andrea Marchesi, Wengang Chai, Ryan McBerney, Tomasz P. Kamiński, Matthew R. Balmforth, Alexandra Tamasanu, James D. Finnigan, Carl Young, Stuart L. Warriner, Michael E. Webb, Martin A. Fascione, Sabine Flitsch, M. Carmen Galan, Ten Feizi, Matthew I. Gibson, Yan Liu, W. Bruce Turnbull, Bruno Linclau
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Glycan-mediated interactions play a crucial role in biology and medicine, influencing signalling, immune responses, and disease pathogenesis. However, the use of glycans in biosensing and diagnostics is limited by cross-reactivity, as certai
Externí odkaz:
https://doaj.org/article/45fc41374e2f4ce2b12a1822076a1c13
Autor:
Emily E. Kempa, James L. Galman, Fabio Parmeggiani, James R. Marshall, Julien Malassis, Clement Q. Fontenelle, Jean-Baptiste Vendeville, Bruno Linclau, Simon J. Charnock, Sabine L. Flitsch, Nicholas J. Turner, Perdita E. Barran
Publikováno v:
JACS Au, Vol 1, Iss 4, Pp 508-516 (2021)
Externí odkaz:
https://doaj.org/article/34a43ef107ba44e88b736b23d77fadc9
Autor:
Benjamin Jeffries, Zhong Wang, Robert I. Troup, Anaïs Goupille, Jean-Yves Le Questel, Charlene Fallan, James S. Scott, Elisabetta Chiarparin, Jérôme Graton, Bruno Linclau
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2141-2150 (2020)
A systematic comparison of lipophilicity modulations upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl substituents, at a single carbon atom, is provided using directly comparable, and easily accessible model compounds. In addition, comparis
Externí odkaz:
https://doaj.org/article/5644f5bd717b453ba99d0547aa77d2b0
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2883-2887 (2017)
The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts in the synthesis of anti-2,3-difluorobutane-1,4-diol, as well as the synthesis of the corr
Externí odkaz:
https://doaj.org/article/21161b8923cc4b34bd071368d7fbf1f9
Publikováno v:
Angewandte Chemie International Edition. 62
Bioactive compounds generally need to cross membranes to arrive at their site of action. The octanol-water partition coefficient (lipophilicity, logP OW) has proven to be an excellent proxy for membrane permeability. In modern drug discovery, logP OW
Autor:
Tessa Keenan, Natasha Hatton, Jack Porter, Jean-Baptiste Vendeville, David Wheatley, Mattia Ghirardello, Alice Wahart, Sanaz Ahmadipour, Julia Walton, Carmen Galan, Bruno Linclau, Gavin Miller, Martin Fascione
b-Mannosides are ubiquitous in nature, with diverse roles in many biological processes. Notably, Manb1,4GlcNAc a constituent of the core N-glycan in eukaryotes, was recently identified as a STING immune pathway activator, highlighting its potential f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75c51d2446bd02e77f79e6a7b02a7a2d
https://doi.org/10.26434/chemrxiv-2023-3dql5
https://doi.org/10.26434/chemrxiv-2023-3dql5
Autor:
Kler Huonnic, Bruno Linclau
Publikováno v:
CHEMICAL REVIEWS
Fluorinated carbohydrates have found many applications in the glycosciences. Typically, these contain fluorination at a single position. There are not many applications involving polyfluorinated carbohydrates, here defined as monosaccharides in which
Autor:
Sarah-Jane Richards, Tessa Keenan, Jean-Baptiste Vendeville, David E. Wheatley, Harriet Chidwick, Darshita Budhadev, Claire E. Council, Claire S. Webster, Helene Ledru, Alexander N. Baker, Marc Walker, M. Carmen Galan, Bruno Linclau, Martin A. Fascione, Matthew I. Gibson
Publikováno v:
Chemical Science
Galectins are potential biomarkers and therapeutic targets. However, galectins display broad affinity towards β-galactosides meaning glycan-based (nano)biosensors lack the required selectivity and affinity. Using a polymer-stabilized nanoparticle bi
Autor:
J. Daniel Martínez, Pablo Valverde, Sandra Delgado, Cecilia Romanò, Bruno Linclau, Niels C. Reichardt, Stefan Oscarson, Ana Ardá, Jesús Jiménez-Barbero, F. Javier Cañada
Publikováno v:
Molecules, Vol 24, Iss 12, p 2337 (2019)
A fluorine nuclear magnetic resonance (19F-NMR)-based method is employed to assess the binding preferences and interaction details of a library of synthetic fluorinated monosaccharides towards dendritic cell-specific intercellular adhesion molecule 3
Externí odkaz:
https://doaj.org/article/36fc43d916b04b25b8609f9786b84013
Autor:
Bruno Linclau, Zhong Wang, Benjamin Jeffries, Jérôme Graton, Rodrigo J. Carbajo, Davy Sinnaeve, Jean‐Yves Le Questel, James S. Scott, Elisabetta Chiarparin
Publikováno v:
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2022, 61 (7), pp.e202114862. ⟨10.1002/anie.202114862⟩
Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2022, 61 (7), pp.e202114862. ⟨10.1002/anie.202114862⟩
International audience; Efficient drug discovery is based on a concerted effort in optimizing bioactivity and compound properties such as lipophilicity, and is guided by efficiency metrics that reflect both aspects. While conformation–activity rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7947653456209f8ebd1ed1b35db503b
https://hdl.handle.net/1854/LU-8756122
https://hdl.handle.net/1854/LU-8756122