CYP11B2 inhibitor dexfadrostat phosphate suppresses the aldosterone-to-renin ratio, an indicator of sodium retention, in healthy volunteers.

Autor: Mulatero P; Division of Internal Medicine and Hypertension, University of Torino, Torino, Italy., Groessl M; Clinic for Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Vogt B; Clinic for Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Schumacher C; DAMIAN Pharma AG, Walchwil, Switzerland., Steele RE; DAMIAN Pharma AG, Walchwil, Switzerland., Brooks A; Covance Clinical Research, Leeds, UK., Hossack S; Covance Clinical Research, Leeds, UK., Brunner HR; Faculty of Biology and Medicine, Lausanne University, Lausanne, Switzerland.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2023 Aug; Vol. 89 (8), pp. 2483-2496. Date of Electronic Publication: 2023 Apr 10.

Effect of a new angiotensin converting enzyme inhibitor MK 421 and its lysine analogue on the components of the renin system in healthy subjects. 1981.

Autor: Brunner DB, Desponds G, Biollaz J, Keller I, Ferber F, Gavras H, Brunner HR, Schelling JL

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2004 Dec; Vol. 58 (7), pp. S778-84; discussion S785-7.

Effects of Neuropeptide Y on Intrarenal Hemodynamics, Plasma Renin Activity and Urinary Sodium Excretion in Rats

Autor: Waeber B, J. Diezi, Jérôme Biollaz, Jürg Nussberger, Jean-François Aubert, Evéquoz D, Brunner Hr

Publikováno v: Nephron. 73:467-472

Neuropeptide Y (NPY) is a vasoconstrictor peptide possibly involved in the regulation of renal sodium handling and renin release. This investigation was undertaken to assess in conscious normotensive rats the acute effects of a non-pressor dose of NP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0a8b50b2c6e4ee3029077eb9e73f67
https://doi.org/10.1159/000189112

Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target‐mediated drug disposition and OATP1B3‐mediated hepatic uptake in a physiologically based model.

Autor: Tsuchitani, Toshiaki^1,2 (AUTHOR), Tomaru, Atsuko² (AUTHOR), Aoki, Yasunori^2,3 (AUTHOR), Ishiguro, Naoki⁴ (AUTHOR), Tsuda, Yasuhiro⁵ (AUTHOR), Sugiyama, Yuichi^1,2 (AUTHOR) y‐sugiyama@jiu.ac.jp

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. Jul2024, Vol. 13 Issue 7, p1224-1237. 14p.

The potential of aromatase inhibitors in fish masculinization: a comprehensive review of applications, mechanisms and future perspectives.

Autor: Lal, Jham¹, Vaishnav, Anand¹, Khogen Singh, Soibam¹ gengang@gmail.com, Biswas, Pradyut¹, Kumar Mehta, Naresh¹, Kumar Meena, Dharmendra^1,2 dkmeenacifri@gmail.com, Waikhom, Gusheinzed¹

Publikováno v: International Aquatic Research. Jun2024, Vol. 16 Issue 2, p113-142. 30p.