Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Brunilde Arseni"'
1
Efficacy of a Nanocochleate-Encapsulated 3,5-Diaryl-s-Triazole Derivative in a Murine Model of Graft-Versus-Host Disease
Autor: Ruying Lu, Susan Bonitz, Paolo Carminati, Valeria D'Alessio, Diletta Di Mitri, Brunilde Arseni, Patrick Ahl, Luca Battistini, Rita De Santis, Stefania Rossi, Joel Ngoje, Silvia Campo, Vito Ruggiero, Raphael J. Mannino
Publikováno v: Transplantation. 86:171-175
We have previously demonstrated that the compound 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole exerts immunosuppressive effects in several experimental models of autoimmunity. These results were achieved by subcutaneously administering ST1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b972e70b82087d3305bbc62e49638b
https://doi.org/10.1097/tp.0b013e31817ba761
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2
Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound
Autor: Silvia Campo, Federica Capolunghi, Claudio Sette, Nicola Fanto, Maria Loiarro, Rita De Santis, Vito Ruggiero, Paolo Carminati, Brunilde Arseni, Grazia Gallo, Rita Carsetti
Publikováno v: Journal of Leukocyte Biology. 82:801-810
MyD88 is an adaptor protein, which plays an essential role in the intracellular signaling elicited by IL-1R and several TLRs. Central to its function is the ability of its Toll/IL-1R translation initiation region (TIR) domain to heterodimerize with t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee39200ec2259332b89a8b679b46420e
https://doi.org/10.1189/jlb.1206746
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3
Low and High Tenascin-Expressing Tumors Are Efficiently Targeted by ST2146 Monoclonal Antibody
Autor: Antonio Verdoliva, Pierino Chiodi, Anna Maria Anastasi, Antonio Rosi, Giovanni Cassani, Marco Chinol, Rita De Santis, Valeria D'Alessio, Paolo Carminati, Giovanni Paganelli, Brunilde Arseni, Claudio Albertoni, Nadia Caroni, Silvia Campo, Fiorella Petronzelli, Ragnar Lindstedt
Publikováno v: Clinical Cancer Research. 12:2191-2196
ST2146biot is a biotinylated anti-tenascin monoclonal antibody (mAb) to be used for Pretargeted Antibody Guided Radioimmunotherapy (PAGRIT) of solid tumors. In vivo biodistribution studies of 125I-labeled ST2146biot were done in nude mice transplante
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b045895343b299c65c4ae9a792e17364
https://doi.org/10.1158/1078-0432.ccr-05-2526
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4
Efficacy of PTX3 and Posaconazole Combination in a Rat Model of Invasive Pulmonary Aspergillosis
Autor: Giovanni Salvatori, Roberta Gaziano, Brunilde Arseni, Luigi Aurisicchio, Rita De Santis, Emanuele Marra, M. Lucrezia Pacello, Vitor L. Sousa
Posaconazole is currently used for the prophylaxis of invasive pulmonary aspergillosis (IPA). Limitations to posaconazole usage are drug-drug interactions and side effects. PTX3 is an innate immunity glycoprotein with opsonic activity, proven to be p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f07b92872eeecf90f0738bb2723276
https://europepmc.org/articles/PMC4187902/
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5
PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis
Autor: Rita De Santis, Silvia Moretti, Luigina Romani, Giovanni Salvatori, Alberto Mantovani, Silvia Bozza, Barbara Bottazzi, Brunilde Arseni, Antonio Inforzato, Lindstedt Ragnar, Agostinho Carvalho, Silvia Campo, Vasileios Oikonomous
Publikováno v: The Journal of Immunology
The long pentraxin 3 (PTX3) modulates different effector pathways involved in innate resistance to Aspergillus fumigatus, including complement activation or promotion of phagocytosis by interacting with FcγRs. However, whether and how TLRs modulate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab5f2234340a57056760d4beb26fcd5
http://hdl.handle.net/11391/1356032
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6
Anti-proliferative effect of a triazole derivative (ST1959) on LNCaP human prostate cancer cells through down-regulation of cyclin and androgen receptor expression
Autor: Stefania Rossi, Claudio Sette, Brunilde Arseni, Valeria D'Alessio, Rita De Santis, Maria Loiarro, Vito Ruggiero, Silvia Campo
Publikováno v: The Prostate. 71(1)
BACKGROUND. Previous studies demonstrated that ST1959, a triazole derivative endowed with immunomodulatory activities, also exerts inhibitory effects on proliferation and survival of a panel of tumor cells. In this study, we sought to ascertain the e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821e78b51175a29a9876fd8a9b3ab22f
https://pubmed.ncbi.nlm.nih.gov/20607765
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7
Dissecting drug and vehicle metabolic effects in rats by a metabonomic approach
Autor: Rita De Santis, Paolo Carminati, Filippo Conti, Stefania Rossi, Mauro Colafranceschi, Vito Ruggiero, Mariacristina Valerio, Alberta Tomassini, Giorgio Capuani, Silvia Campo, Brunilde Arseni, Alfredo Miccheli, Alessandro Giuliani
Publikováno v: Journal of biochemical and biophysical methods. 70(3)
A combined application of high resolution 1 H NMR spectroscopy and multivariate statistical techniques focused on establishing a consistent statistical approach to metabonomic studies was tested. The data reduction, which is preliminary to the applic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4320cdc94bac4832b5c1218ff58d4e3
https://pubmed.ncbi.nlm.nih.gov/17011038
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8
Comparative activity of Sant7 and anti-IL-6, IL-6R monoclonal antibodies in a murine model of B-cell lymphoma
Autor: Ottaviano Serlupi-Crescenzi, Paolo Carminati, Stefania Rossi, Isabella Saggio, Brunilde Arseni, Rita De Santis, Silvia Campo, Barbara Salone, Gioia Cherubini
Publikováno v: Cytokine. 31(5)
Interleukin-6 (IL-6) plays a central role in the pathogenesis of several autoimmune and inflammatory diseases as well as B-cell lymphoproliferative disorders. This work describes the effects of the recombinant or adenovirally-delivered IL-6 superanta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba887aced098212da1efd9bd2d97085d
https://pubmed.ncbi.nlm.nih.gov/16061391
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