Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Brunhilde Hähnel"'
Autor:
Franziska Theilig, Wilhelm Kriz, Robert Koesters, Michel LeHir, Hiltraud Hosser, Nicolas Picard, Rolf Gebhardt, Brigitte Kaissling, Adam B. Glick, Brunhilde Hähnel, Hermann Josef Gröne
Publikováno v:
The American Journal of Pathology. 177:632-643
We recently showed in a tetracycline-controlled transgenic mouse model that overexpression of transforming growth factor (TGF)-beta1 in renal tubules induces widespread peritubular fibrosis and focal degeneration of nephrons. In the present study we
Autor:
Sebastian Bachmann, Franziska Theilig, Brunhilde Hähnel, Michel Le Hir, Wilhelm Kriz, Thomas E. Willnow, Timo Jerichow, Petra Schrade
Publikováno v:
Journal of the American Society of Nephrology. 18:1824-1834
Sustained proteinuria and tubulointerstitial damage have been closely linked with progressive renal failure. Upon excess protein endocytosis, tubular epithelial cells are thought to produce mediators that promote inflammation, tubular degeneration, a
Autor:
Barbara Lewko, Jacek M. Witkowski, Ewa Bryl, Nicole Endlich, Brunhilde Hähnel, Stefan Angielski, Jan Stepinski, Magdalena Gołos, Wilhelm Kriz, Claudia Koksch, Elżbieta Latawiec
Publikováno v:
Kidney and Blood Pressure Research. 28:1-7
The nonmetabolizable glucose analogue [3H]-2-deoxy-D-glucose (3H-2DG) was used to study glucose transport in cultured rat podocytes. Intracellular accumulation of 3H-2DG was linear up to 20 min and was inhibited by cytochalasin B (80% inhibition) and
Publikováno v:
Journal of the American Society of Nephrology. 15:1475-1487
Angiotensin II (AngII) is a critical determinant of glomerular function involving both hemodynamic and pressure-independent effects that are insufficiently understood. A novel transgenic rat (TGR) model with overexpression of the human AngII type 1 r
Autor:
Hiltraud Hosser, Bettina Kränzlin, Wilhelm Kriz, Norbert Gretz, Brunhilde Hähnel, Marlies Elger, Abraham P. Provoost
Publikováno v:
Kidney and Blood Pressure Research. 22:26-36
Severe podocyte damage including detachment from the GBM leads to adhesion of the glomerular tuft to Bowman’s capsule, thus to a local loss of the separation of the tuft from the interstitium. Perfused capillaries contained in the tuft adhesion del
Publikováno v:
Kidney International. 48:1435-1450
Long-term treatment of rats with FGF-2 results in focal segmental glomerulosclerosis. Long-term treatment (8 and 13 weeks) of rats with FGF-2 led to albuminuria and to increase in serum creatinine indicating the development of chronic renal failure.
Autor:
Milena Traykova-Brauch, Hermann Josef Gröne, Brunhilde Hähnel, Wilhelm Kriz, Hiltraud Hosser, Marcus J. Moeller, Brigitte Kaissling, Robert Koesters, Samy Hakroush, Franziska Theilig, Tjeerd P. Sijmonsma, Ann L. Akeson, Manfred Jugold
Publikováno v:
The American journal of pathology. 175(5)
The role of vascular endothelial growth factor (VEGF) in renal fibrosis, tubular cyst formation, and glomerular diseases is incompletely understood. We studied a new conditional transgenic mouse system [Pax8-rtTA/(tetO)(7)VEGF], which allows increase
Autor:
Wilhelm Kriz, Brunhilde Hähnel, Hein A. Koomans, Dionne M. van der Giezen, David A. Ishola, Roel Goldschmeding, Jaap A. Joles
BACKGROUND: The availability of genetically modified mice has increased the need for relevant mouse models of renal disease, but widely used C57BL/6 mice often show resistance to proteinuria. 129/Sv mice are considered more sensitive to certain renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb5634884d32cd603b1643e610c2efd
https://researchonline.lshtm.ac.uk/id/eprint/4411395/1/gfi303.pdf
https://researchonline.lshtm.ac.uk/id/eprint/4411395/1/gfi303.pdf
Autor:
Wilhelm Kriz, Bettina Kränzlin, Ingrid Hartmann, Brunhilde Hähnel, Abaraham P. Provoost, Hil Traud Hosser, Norbert Gretz
Publikováno v:
Journal of the American Society of Nephrology : JASN. 12(3)
In two genetic models of "classic" focal segmental glomerulosclerosis (FSGS), the Milan normotensive and the Fawn-hooded hypertensive rats, tracer studies were performed to test the hypothesis that misdirected glomerular filtration and peritubular fi
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 13(11)
by misdirected filtrate spreading. Similar to the situation observed at the glomerulus this space becomes Background. Focal segmental glomerulosclerosis (FSGS ) is consistently associated with tubular degen- separated from the interstitium by a layer