A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

Autor: Bruner, Katherine M, Wang, Zheng, Simonetti, Francesco R, Bender, Alexandra M, Kwon, Kyungyoon J, Sengupta, Srona, Fray, Emily J, Beg, Subul A, Antar, Annukka AR, Jenike, Katharine M, Bertagnolli, Lynn N, Capoferri, Adam A, Kufera, Joshua T, Timmons, Andrew, Nobles, Christopher, Gregg, John, Wada, Nikolas, Ho, Ya-Chi, Zhang, Hao, Margolick, Joseph B, Blankson, Joel N, Deeks, Steven G, Bushman, Frederic D, Siliciano, Janet D, Laird, Gregory M, Siliciano, Robert F

Publikováno v: Nature, vol 566, iss 7742

A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1-3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays. The reservoir was defined with quant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::86758c847526ab9c60c9f405bc6414be
https://escholarship.org/uc/item/86v1b54b

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Defective proviruses rapidly accumulate during acute HIV-1 infection

Autor: Bruner, Katherine M, Murray, Alexandra J, Pollack, Ross A, Soliman, Mary G, Laskey, Sarah B, Capoferri, Adam A, Lai, Jun, Strain, Matthew C, Lada, Steven M, Hoh, Rebecca, Ho, Ya-Chi, Richman, Douglas D, Deeks, Steven G, Siliciano, Janet D, Siliciano, Robert F

Publikováno v: Bruner, Katherine M; Murray, Alexandra J; Pollack, Ross A; Soliman, Mary G; Laskey, Sarah B; Capoferri, Adam A; et al.(2016). Defective proviruses rapidly accumulate during acute HIV-1 infection.. Nature medicine, 22(9), 1043-1049. doi: 10.1038/nm.4156. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/78h9x20k
Nature medicine, vol 22, iss 9

Although antiretroviral therapy (ART) suppresses viral replication to clinically undetectable levels, human immunodeficiency virus type 1 (HIV-1) persists in CD4(+) T cells in a latent form that is not targeted by the immune system or by ART. This la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::267345bac653a95e79c89d8be8f096f1
http://www.escholarship.org/uc/item/78h9x20k

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