Výsledky vyhledávání - "Brunella Taddeo"

Akademický článek

Fibroblast Growth Factor-2 and the HIV-1 Tat Protein Synergize in Promoting Bcl-2 Expression and Preventing Endothelial Cell Apoptosis: Implications for the Pathogenesis of AIDS-Associated Kaposi's Sarcoma

Autor: Cecilia Sgadari, Giovanni Barillari, Clelia Palladino, Stefania Bellino, Brunella Taddeo, Elena Toschi, Barbara Ensoli

Publikováno v: International Journal of Vascular Medicine, Vol 2011 (2011)

Kaposi's sarcoma (KS) is a vascular tumor frequently occurring in Human Immunodeficiency Virus- (HIV-) 1-infected individuals. Our previous work indicated that the angiogenic fibroblast growth factor (FGF)-2 and the Tat protein of HIV-1, both express

Externí odkaz: https://doaj.org/article/8b33b0fbab634b5cb2e90db38b2ff327

Zobrazit plný text záznamu

The Nuclear-Cytoplasmic Shuttling of Virion Host Shutoff RNase Is Enabled by pU L 47 and an Embedded Nuclear Export Signal and Defines the Sites of Degradation of AU-Rich and Stable Cellular mRNAs

Autor: Brunella Taddeo, Minfeng Shu, Bernard Roizman

Publikováno v: Journal of Virology. 87:13569-13578

The herpes simplex virus host shutoff RNase (VHS-RNase) is the major early block of host responses to infection. VHS-RNase is introduced into cells during infection and selectively degrades stable mRNAs made before infection and the normally short-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659e4d96591b78388bee2dc14b6bea5a
https://doi.org/10.1128/jvi.02603-13

Zobrazit plný text záznamu

The Herpes Simplex Virus Host Shutoff RNase Degrades Cellular and Viral mRNAs Made before Infection but Not Viral mRNA Made after Infection

Autor: Brunella Taddeo, Bernard Roizman, Weiran Zhang

Publikováno v: Journal of Virology. 87:4516-4522

A herpes simplex virus tegument protein brought into the cell during infection and designated the virion host shutoff protein (VHS) is an endoribonuclease that degrades mRNA. The prevailing view for many years has been that the VHS-RNase does not dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7573901b90cf9214f1ad4055ed04c818
https://doi.org/10.1128/jvi.00005-13

Zobrazit plný text záznamu

Role of Herpes Simplex Virus ICP27 in the Degradation of mRNA by Virion Host Shutoff RNase

Autor: Brunella Taddeo, Weiran Zhang, Bernard Roizman

Publikováno v: Journal of Virology. 84:10182-10190

The virion host shutoff (VHS) RNase tegument protein released into cells by infecting virus has two effects. Preexisting stable mRNAs (e.g., GAPDH [glyceraldehyde-3-phosphate dehydrogenase]) are rapidly degraded. Stress response RNAs containing AU-ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bdb4c2c9a99d6b72fa4d77d796fcbc1
https://doi.org/10.1128/jvi.00975-10

Zobrazit plný text záznamu

Replication-Competent Herpes Simplex Virus 1 Isolates Selected from Cells Transfected with a Bacterial Artificial Chromosome DNA Lacking Only the U L 49 Gene Vary with Respect to the Defect in the U L 41 Gene Encoding Host Shutoff RNase

Autor: Maria Giuffrè-Cuculletto, Maria Teresa Sciortino, Bernard Roizman, Maria Antonietta Medici, Antonio Mastino, Brunella Taddeo

Publikováno v: Journal of Virology. 81:10924-10932

To generate a null U L 49 gene mutant of herpes simplex virus 1 (HSV-1), we deleted from the viral DNA, encoded as a bacterial artificial chromosome (BAC), the U L 49 open reading frame and, in a second step, restored it. Upon transfection into Vero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a561088c73602fd110bd6e82f0569613
https://doi.org/10.1128/jvi.01239-07

Zobrazit plný text záznamu

Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA

Autor: Bernard Roizman, Maria Teresa Sciortino, Brunella Taddeo, Weiran Zhang

Publikováno v: Proceedings of the National Academy of Sciences. 104:12163-12168

The virion host shutoff (vhs) protein encoded by the U L 41 gene of herpes simplex virus 1 is an endoribonuclease. The enzyme is introduced into the cell during unpackaging of the virion upon entry and selectively degrades mRNA for several hours. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a29b827fd88b27a0e98d34cddbdf37
https://doi.org/10.1073/pnas.0705245104

Zobrazit plný text záznamu

The Virion Host Shutoff Protein (U L 41) of Herpes Simplex Virus 1 Is an Endoribonuclease with a Substrate Specificity Similar to That of RNase A

Autor: Bernard Roizman, Brunella Taddeo

Publikováno v: Journal of Virology. 80:9341-9345

Earlier, our laboratory reported that purified glutathione S -transferase-virion host shutoff (GST- vhs ) protein exhibited endoribonucleolytic activity in in vitro assays using as substrates in vitro-transcribed regions of IEX-1 mRNA. Here, we repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55ee1c65044d93f7b3d23f6013c9166
https://doi.org/10.1128/jvi.01008-06

Zobrazit plný text záznamu

The U L 41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins

Autor: Bernard Roizman, Weiran Zhang, Brunella Taddeo

Publikováno v: Proceedings of the National Academy of Sciences. 103:2827-2832

The herpes simplex virus 1 ORF U L 41 encodes a protein (virion host shutoff or vhs ) associated with selective degradation of mRNA early in infection. Some mRNAs, exemplified by GAPDH or β-actin mRNAs, are degraded rapidly. Others, for example IEX-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6ade69a527db2cb6d60ad6d1c027533
https://doi.org/10.1073/pnas.0510712103

Zobrazit plný text záznamu

Cells Lacking NF-κB or in Which NF-κB Is Not Activated Vary with Respect to Ability To Sustain Herpes Simplex Virus 1 Replication and Are Not Susceptible to Apoptosis Induced by a Replication-Incompetent Mutant Virus

Autor: Bernard Roizman, Fred D. Lakeman, Brunella Taddeo, Weiran Zhang

Publikováno v: Journal of Virology. 78:11615-11621

Earlier we reported that NF-κB is activated by protein kinase R (PKR) in herpes simplex virus 1-infected cells. Here we report that in PKR −/− cells the yields of wild-type virus are 10-fold higher than in PKR +/+ cells. In cells lacking NF-κB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d7329a17fe7bc5d3e2af192d19e68a
https://doi.org/10.1128/jvi.78.21.11615-11621.2004

Zobrazit plný text záznamu

Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells

Autor: Audrey Esclatine, Brunella Taddeo, Bernard Roizman

Publikováno v: Biochemical Society Transactions. 32:697-701

In HSV-1 (herpes simplex virus 1)-infected cells, the U(L)41 gene product carried with the virion has been shown to mediate the degradation of mRNA, leading to the shut-off of cellular protein synthesis. Analysis of the RNAs accumulating in cells inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982418ca663ab818a55b720c3dc82a37
https://doi.org/10.1042/bst0320697

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání