Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Bruna Zuculoto da Costa"'
Autor:
Bruna Zuculoto da Costa, Carl Young, Ying Zhuo, Ashleigh J. Burke, Simon J. Charnock, Nicholas J. Turner, Anthony P. Green, William R. Birmingham, Thomas W. Thorpe, Rebecca Crawshaw, Ian Rowles, James Finnigan, Sarah L. Lovelock
The COVID-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue currently in phase 3 clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b8f19109e30db608bd4fd17b143b33
https://doi.org/10.26434/chemrxiv-2021-vfkqb-v3
https://doi.org/10.26434/chemrxiv-2021-vfkqb-v3
Autor:
Ashleigh Burke, William Birmingham, Ying Zhuo, Bruna Zuculoto da Costa, Rebecca Crawshaw, Thomas Thorpe, Ian Rowles, James Finnigan, Simon J. Charnock, Sarah Lovelock, Nicholas Turner, Anthony Green
The COVID-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue currently in phase 3 clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3688f1a1f70c6dc1b5c614d2f6d2b91b
https://doi.org/10.26434/chemrxiv-2021-vfkqb-v2
https://doi.org/10.26434/chemrxiv-2021-vfkqb-v2
Autor:
Ashleigh Burke, William Birmingham, Ying Zhuo, Bruna Zuculoto da Costa, Rebecca Crawshaw, Thomas Thorpe, Ian Rowles, James Finnigan, Simon J. Charnock, Sarah Lovelock, Nicholas Turner, Anthony Green
Herein we report the conversion of cytidine 2 to N-hydroxycytidine 7 catalysed by cytidine deaminase (CD). The wild-type enzyme operates efficiently at high sustrate loadings and hydroxylamine concentrations to favor N-hydroxy-cytidine formation over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb54cbdd2a26ca1d112934b5480bd0e
https://doi.org/10.26434/chemrxiv.13721692
https://doi.org/10.26434/chemrxiv.13721692