Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Bruna Minatovicz"'
Autor:
Tai-Hsi Fan, Ji-Qin Li, Bruna Minatovicz, Elizabeth Soha, Li Sun, Sajal Patel, Bodhisattwa Chaudhuri, Robin Bogner
Publikováno v:
Polymers, Vol 11, Iss 1, p 10 (2018)
Bulk solutions of therapeutic proteins are often frozen for long-term storage. During the freezing process, proteins in liquid solution redistribute and segregate in the interstitial space between ice crystals. This is due to solute exclusion from ic
Externí odkaz:
https://doaj.org/article/c578a83381ee47659c123666c44e9a82
Publikováno v:
Journal of pharmaceutical sciences.
Although bulk biotherapeutics are often frozen during fill finish and shipping to improve their stability, they can undergo degradation leading to losses in biological activity during sub-optimal freeze-thaw (F/T) process. Except for a few small-scal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d8240a6e1e0c1452df172ec52b31db
https://pubmed.ncbi.nlm.nih.gov/36162492
https://pubmed.ncbi.nlm.nih.gov/36162492
Publikováno v:
AAPS PharmSciTech. 22
Large volumes of protein solutions are commonly stored in a frozen state before further drug product fill and finish. This study aimed to establish a design space to perform large-scale freeze-thaw (F/T) processes of biotherapeutics without inducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9d8f530214e82a6094a77726fb6216
https://doi.org/10.1208/s12249-021-02034-6
https://doi.org/10.1208/s12249-021-02034-6
Autor:
Hossein Mohammadiarani, Bruna Minatovicz, Bodhisattwa Chaudhuri, Dongkwan Shin, Jun Bai, Tibo Duran
Publikováno v:
Journal of pharmaceutical sciences. 110(6)
Freezing is a common process applied in the pharmaceutical industry to store and transport biotherapeutics. Herewith, multi-scale molecular dynamics simulations of Lactate dehydrogenase (LDH) protein in phosphate buffer with/without ice formation per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad1299489282b8bcf30b794ea633283
https://pubmed.ncbi.nlm.nih.gov/33421436
https://pubmed.ncbi.nlm.nih.gov/33421436
Publikováno v:
Drug Development and Industrial Pharmacy. 43:1677-1685
Pulmonary delivery of cohesive and micronized drugs through dry powder inhalers (DPIs) is traditionally achieved through the formation of ordered mixtures. In order to improve the mechanistic understanding of formation of ordered mixtures, the system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8414be361cc0ab41f29a0bd8197522ab
https://doi.org/10.1080/03639045.2017.1338719
https://doi.org/10.1080/03639045.2017.1338719
Publikováno v:
Journal of Pharmaceutical Sciences. 106:129-139
The purpose of the present study was to develop guidance toward rational choice of blenders and processing conditions to make robust and high performing adhesive mixtures for dry-powder inhalers and to develop quantitative experimental approaches for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f572b697e0a1eeb43bd8bfe0b82d5a
https://doi.org/10.1016/j.xphs.2016.07.012
https://doi.org/10.1016/j.xphs.2016.07.012
Autor:
Mohammed Shameem, Bodhisattwa Chaudhuri, Bruna Minatovicz, Charlie (Xiaolin) Tang, Christopher Foran, Li Sun
Publikováno v:
Journal of Drug Delivery Science and Technology. 58:101703
Storage of protein therapeutics in a frozen state provides operational flexibility for fill and finish of drug products and extends the shelf life of protein solutions. However, freezing of bulk protein solutions leads to progressive freeze-concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c44f079f2b4ecc904608bbc5eb33683
https://doi.org/10.1016/j.jddst.2020.101703
https://doi.org/10.1016/j.jddst.2020.101703
Autor:
Xiuling Lu, Bruna Minatovicz, Geoff G. Z. Zhang, André O'Reilly Beringhs, Bodhisattwa Chaudhuri
Publikováno v:
AAPS PharmSciTech. 19(7)
FDA-approved self-emulsifying medicines rely on liquid-based formulations, which can exhibit limited stability and short shelf-lives. Solid self-emulsifying drug delivery systems (SEDDS) can improve such issues, but there is still a great need for id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7658a2de7d6d4799598209fedf4e9e
https://pubmed.ncbi.nlm.nih.gov/30218264
https://pubmed.ncbi.nlm.nih.gov/30218264
Autor:
Bruna Minatovicz, Li Sun, Bodhisattwa Chaudhuri, Tai-Hsi Fan, Ji-Qin Li, Elizabeth Soha, Robin H. Bogner, Sajal M. Patel
Publikováno v:
Polymers
Volume 11
Issue 1
Polymers, Vol 11, Iss 1, p 10 (2018)
Volume 11
Issue 1
Polymers, Vol 11, Iss 1, p 10 (2018)
Bulk solutions of therapeutic proteins are often frozen for long-term storage. During the freezing process, proteins in liquid solution redistribute and segregate in the interstitial space between ice crystals. This is due to solute exclusion from ic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044fcb97f2292e45d60cd0dcd41d3d4d
https://doi.org/10.3390/polym11010010
https://doi.org/10.3390/polym11010010
Autor:
Ana Carolina Lourenço, Ana Claudia Boareto, Bruna Minatovicz, Sandra Crestani, Paulo Roberto Dalsenter, Anderson Joel Martino-Andrade, Arquimedes Gasparotto, Caroline Gomes, Juliane Centeno Muller, Emerson Luiz Botelho Lourenço
Publikováno v:
Journal of Ethnopharmacology. 141(1):418-423
Ethnopharmacological relevance Tropaeolum majus L. (Tropaeolaceae) is a medicinal herb popularly used in Brazil for treatment of inflammatory and cardiovascular diseases. Despite some published data on its efficacy, there are still few toxicological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3d911f58b1a9209ca6b250ab692ea1