Mannosyltransferase (GPI-14) overexpression protects promastigote and amastigote forms of Leishmania braziliensis against trivalent antimony

Autor: Christiana Vargas Ribeiro, Bruna Fonte Boa Rocha, Douglas de Souza Moreira, Vanessa Peruhype-Magalhães, Silvane Maria Fonseca Murta

Publikováno v: Parasites & Vectors, Vol 12, Iss 1, Pp 1-7 (2019)

Abstract Background Glycosylphosphatidylinositol is a surface molecule important for host-parasite interactions. Mannosyltransferase (GPI-14) is an essential enzyme for adding mannose on the glycosylphosphatidyl group. This study attempted to overexp

Externí odkaz: https://doaj.org/article/c10756b65d93403bb031caf85ed79727

Leishmania infantum induces high phagocytic capacity and intracellular nitric oxide production by human proinflammatory monocyte

Autor: Andréa Teixeira-Carvalho, Christiana Vargas Ribeiro, Bruna Fonte Boa Rocha, Edward Oliveira, Silvane M. F. Murta, Olindo Assis Martins-Filho, Vanessa Peruhype-Magalhães

Publikováno v: Memórias do Instituto Oswaldo Cruz.
Memórias do Instituto Oswaldo Cruz, Volume: 115, Article number: e190408, Published: 17 APR 2020
Memórias do Instituto Oswaldo Cruz

BACKGROUND The mechanism of resistance to SbIII in Leishmania is complex, multifactorial and involves not only biochemical mechanisms, but also other elements, such as the immune system of the host. OBJECTIVES In this study, putative changes in the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acd36a4c636a38e3511cb2bc9c08571
https://doi.org/10.1590/0074-02760190408