Výsledky vyhledávání - "Bruna Canova"

Regioselectively controlled synthesis of 3(5)-(trifluoromethyl)pyrazolylbenzenesulfonamides and their effects on a pathological pain model in mice

Autor: Marcio M. Lobo, Bruna Canova, Osmar Norberto de Souza, Josiane M. dos Santos, Luis Fernando Saraiva Macedo Timmers, Sara Marchesan Oliveira, Helio G. Bonacorso, Thiago Félix da Silva, Pablo Machado, Indiara Brusco, Marcos A. P. Martins, Nilo Zanatta

Publikováno v: European journal of medicinal chemistry. 102

This study reports a facile and controllable synthetic method for the preparation of both 1,3- and 1,5-isomers of 4-(3(5)-aryl-3(5)-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamides, as well as a new series of 4-(3-aryl-5-hydroxy-5-(trifluorometh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60185f117ed02b877f4d92846cc9d830
https://pubmed.ncbi.nlm.nih.gov/26263246

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Regioselective synthesis of 1,3- and 1,5-substituted pyrazoles and pyrazolynes analogous of Celecoxib

Autor: Helio G. Bonacorso, Nilo Zanatta, Bruna Canova, Marcio M. Lobo, Marcos A. P. Martins

Publikováno v: Proceedings of the 15th Brazilian Meeting on Organic Synthesis Proceedings.

Some methodologies for the synthesis of Celecoxib have been described, but often resulting an isomeric mixture of pyrazoles (1,3and 1,5-substituited) difficult to separate. 4-alkoxyvinyl trifluoromethyl ketones are important precursors blocks. From t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0937619274ef9ae0e41dae309dbb5fb
https://doi.org/10.5151/chempro-15bmos-bmos2013_20138818469

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