Zobrazeno 1 - 10 of 551 pro vyhledávání: '"Brumshtein B"'
1
Akademický článek
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Autor: Mulato A; Department of Virology, Gilead Sciences, Foster City, California, USA., Lansdon E; Department of Structural Biology and Chemistry, Gilead Sciences, Foster City, California, USA., Aoyama R; Department of Drug Metabolism, Gilead Sciences, Foster City, California, USA., Voigt J; Department of Structural Biology and Chemistry, Gilead Sciences, Foster City, California, USA., Lee M; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Liclican A; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Lee G; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Singer E; Department of Virology, Gilead Sciences, Foster City, California, USA., Stafford B; Department of Drug Metabolism, Gilead Sciences, Foster City, California, USA., Gong R; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Murray B; Department of Drug Metabolism, Gilead Sciences, Foster City, California, USA., Chan J; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Lee J; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Xu Y; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Ahmadyar S; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Gonzalez A; Department of Medicinal Chemistry, Gilead Sciences, Foster City, California, USA., Cho A; Department of Medicinal Chemistry, Gilead Sciences, Foster City, California, USA., Stepan GJ; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Schmitz U; Department of Structural Biology and Chemistry, Gilead Sciences, Foster City, California, USA., Schultz B; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Marchand B; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Brumshtein B; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Wang R; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Yu H; Department of Discovery Sciences and Technology, Gilead Sciences, Foster City, California, USA., Cihlar T; Department of Virology, Gilead Sciences, Foster City, California, USA., Xu L; Department of Medicinal Chemistry, Gilead Sciences, Foster City, California, USA., Yant SR; Department of Virology, Gilead Sciences, Foster City, California, USA.
Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Apr 03; Vol. 68 (4), pp. e0137323. Date of Electronic Publication: 2024 Feb 21.
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2
Akademický článek
Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties.
Autor: Prener L; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, Prague 6 160 00, Czech Republic., Baszczyňski O; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, Prague 6 160 00, Czech Republic.; Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, Prague 2 128 43, Czech Republic., Kaiser MM; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, Prague 6 160 00, Czech Republic., Dračínský M; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, Prague 6 160 00, Czech Republic., Stepan G; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States., Lee YJ; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States., Brumshtein B; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States., Yu H; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States., Jansa P; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States., Lansdon EB; Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States., Janeba Z; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, Prague 6 160 00, Czech Republic.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Feb 09; Vol. 66 (3), pp. 1761-1777. Date of Electronic Publication: 2023 Jan 18.
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3
Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease
Autor: Brumshtein, B, Greenblatt, H, Butters, T, Shaaltiel, Y, Aviezer, D, Silman, I, Futerman, A, Sussman, J
Gaucher disease is caused by mutations in the gene encoding acid beta-glucosidase (GlcCerase), resulting in glucosylceramide (GlcCer) accumulation. The only currently available orally administered treatment for Gaucher disease is N-butyl-deoxynojirim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::a24b3dad61b6e56d37c201e2dad1abc1
https://ora.ox.ac.uk/objects/uuid:3101eae5-d570-4f8c-bf7e-8da5a6199aa4
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4
Akademický článek
Recent Progress in Regulating the Activity of Enzymes with Photoswitchable Inhibitors.
Autor: Chen, Yi1,2 (AUTHOR) yichen@mail.ipc.ac.cn
Publikováno v: Molecules. Oct2024, Vol. 29 Issue 19, p4523. 21p.
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5
Akademický článek
Experiments and Calculation on New N,N- bis -Tetrahydroacridines.
Autor: Hrubaru, Madalina-Marina1,2 (AUTHOR) madalina.hrubaru@gmail.com, Draghici, Constantin1 (AUTHOR) cst_drag@yahoo.com, Ngounoue Kamga, Francis Aurelien3 (AUTHOR) fr.kamga@gmail.com, Diacu, Elena4 (AUTHOR) elena_diacu@yahoo.co.uk, Egemonye, ThankGod C.5 (AUTHOR) egemonyethankgod200@gmail.com, Ekennia, Anthony C.6 (AUTHOR) chemisttony@gmail.com, Ungureanu, Eleonora-Mihaela4 (AUTHOR) elena_diacu@yahoo.co.uk
Publikováno v: Molecules. Sep2024, Vol. 29 Issue 17, p4082. 22p.
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6
Akademický článek
Building shape-focused pharmacophore models for effective docking screening.
Autor: Moyano-Gómez, Paola1,2 (AUTHOR), Lehtonen, Jukka V.3,4 (AUTHOR), Pentikäinen, Olli T.1,2,5 (AUTHOR), Postila, Pekka A.1,2,5 (AUTHOR) pekka.postila@utu.fi
Publikováno v: Journal of Cheminformatics. 8/9/2024, Vol. 16 Issue 1, p1-15. 15p.
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7
Akademický článek
Structural, Biophysical, and Computational Studies of a Murine Light Chain Dimer.
Autor: Arriaza, Ricardo H.1,2 (AUTHOR) anyway.kapingidza@duke.edu, Kapingidza, A. Brenda2 (AUTHOR) cdolamore2@huskers.unl.edu, Dolamore, Coleman2 (AUTHOR) nhyduke@email.sc.edu, Khatri, Kriti1,2 (AUTHOR) khatrikr@msu.edu, O'Malley, Andrea1,2 (AUTHOR) ctchhiv@email.sc.edu, Glesner, Jill3 (AUTHOR) jglesner@inbio.com, Wuenschmann, Sabina3 (AUTHOR) sabina@inbio.com, Hyduke, Noah P.2 (AUTHOR), Easley, William2 (AUTHOR), Chhiv, Charline2 (AUTHOR), Pomés, Anna3 (AUTHOR) apomes@inbio.com, Chruszcz, Maksymilian1,2 (AUTHOR) chruszcz@msu.edu
Publikováno v: Molecules. Jun2024, Vol. 29 Issue 12, p2885. 15p.
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8
Akademický článek
Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis.
Autor: Brumshtein B; From the Departments of Biological Chemistry and Chemistry and Biochemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, UCLA, Los Angeles, California 90095 and., Esswein SR; From the Departments of Biological Chemistry and Chemistry and Biochemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, UCLA, Los Angeles, California 90095 and., Sawaya MR; From the Departments of Biological Chemistry and Chemistry and Biochemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, UCLA, Los Angeles, California 90095 and., Rosenberg G; From the Departments of Biological Chemistry and Chemistry and Biochemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, UCLA, Los Angeles, California 90095 and., Ly AT; From the Departments of Biological Chemistry and Chemistry and Biochemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, UCLA, Los Angeles, California 90095 and., Landau M; the Department of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel., Eisenberg DS; From the Departments of Biological Chemistry and Chemistry and Biochemistry, Howard Hughes Medical Institute, UCLA-DOE Institute, UCLA, Los Angeles, California 90095 and david@mbi.ucla.edu.
Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Dec 21; Vol. 293 (51), pp. 19659-19671. Date of Electronic Publication: 2018 Oct 24.
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9
Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease
Autor: Brumshtein, B, Greenblatt, HM, Butters, TD, Shaaltiel, Y, Aviezer, D, Silman, I, Futerman, AH, Sussman, JL
Publikováno v: The Journal of biological chemistry. 282(39)
Gaucher disease is caused by mutations in the gene encoding acid beta-glucosidase (GlcCerase), resulting in glucosylceramide (GlcCer) accumulation. The only currently available orally administered treatment for Gaucher disease is N-butyl-deoxynojirim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::7ff8120573bcbf4d191775971572bb01
http://ora.ox.ac.uk/objects/uuid:3101eae5-d570-4f8c-bf7e-8da5a6199aa4
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10
Akademický článek
In Silico Study of Camptothecin-Based Pro-Drugs Binding to Human Carboxylesterase 2.
Autor: Beierlein, Frank1,2 (AUTHOR) anselm.horn@fau.de, Horn, Anselm H. C.2,3 (AUTHOR) heinrich.sticht@fau.de, Sticht, Heinrich3 (AUTHOR), Mokhir, Andriy4 (AUTHOR) andriy.mokhir@fau.de, Imhof, Petra1 (AUTHOR) petra.imhof@fau.de
Publikováno v: Biomolecules (2218-273X). Feb2024, Vol. 14 Issue 2, p153. 19p.
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