Chloroformate-mediated ring cleavage of indole alkaloids leads to re-engineered antiplasmodial agents.

Autor: Schultz DC; Department of Medicinal Chemistry, Center for Natural Product Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA. rhuigens@cop.ufl.edu., Chávez-Riveros A; Department of Medicinal Chemistry, Center for Natural Product Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA. rhuigens@cop.ufl.edu., Goertzen MG 2nd; Department of Medicinal Chemistry, Center for Natural Product Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA. rhuigens@cop.ufl.edu., Brummel BR; Department of Medicinal Chemistry, Center for Natural Product Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA. rhuigens@cop.ufl.edu., Paes RA; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32826, USA., Santos NM; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32826, USA., Tenneti S; Department of Medicinal Chemistry, Center for Natural Product Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA. rhuigens@cop.ufl.edu., Abboud KA; Department of Chemistry, University of Florida, Gainesville, Florida 32610, USA., Rocca JR; Department of Medicinal Chemistry, Center for Natural Product Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA. rhuigens@cop.ufl.edu.; McKnight Brain Institute, J H Miller Health Center, University of Florida, Gainesville, Florida 32610, USA., Seabra G; Department of Medicinal Chemistry, Center for Natural Product Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA. rhuigens@cop.ufl.edu., Li C; Department of Medicinal Chemistry, Center for Natural Product Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA. rhuigens@cop.ufl.edu., Chakrabarti D; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida 32826, USA., Huigens RW 3rd; Department of Medicinal Chemistry, Center for Natural Product Drug Discovery & Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA. rhuigens@cop.ufl.edu.

Publikováno v: Organic & biomolecular chemistry [Org Biomol Chem] 2024 Oct 30; Vol. 22 (42), pp. 8423-8436. Date of Electronic Publication: 2024 Oct 30.

Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery.

Autor: Huigens RW 3rd; Center for Natural Products, Drug Discovery and Development (CNPD3), Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA., Brummel BR; Center for Natural Products, Drug Discovery and Development (CNPD3), Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA., Tenneti S; Center for Natural Products, Drug Discovery and Development (CNPD3), Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA., Garrison AT; Center for Natural Products, Drug Discovery and Development (CNPD3), Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA., Xiao T; Center for Natural Products, Drug Discovery and Development (CNPD3), Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, FL 32610, USA.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 Feb 07; Vol. 27 (3). Date of Electronic Publication: 2022 Feb 07.

Ring Distortion of Vincamine Leads to the Identification of Re-Engineered Antiplasmodial Agents.

Autor: Norwood VM 4th; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States., Murillo-Solano C; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States., Goertzen MG 2nd; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States., Brummel BR; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States., Perry DL; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States., Rocca JR; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.; McKnight Brain Institute, J H Miller Health Center, University of Florida, P.O. Box 100015, Gainesville, Florida 32610, United States., Chakrabarti D; Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, 12722 Research Parkway, Orlando, Florida 32826, United States., Huigens RW 3rd; Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.

Publikováno v: ACS omega [ACS Omega] 2021 Jul 28; Vol. 6 (31), pp. 20455-20470. Date of Electronic Publication: 2021 Jul 28 (Print Publication: 2021).

Iodinated Polyesters with Enhanced X-ray Contrast Properties for Biomedical Imaging.

Autor: Lex TR; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA., Brummel BR; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA., Attia MF; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA.; Department of Bioengineering, Clemson University, 301 Rhodes Research Center, Clemson, SC, 29634, USA., Giambalvo LN; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA., Lee KG; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA., Van Horn BA; Department of Chemistry and Biochemistry, College of Charleston, 66 George St., Charleston, SC, 29414, USA., Whitehead DC; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA. dwhiteh@clemson.edu., Alexis F; Department of Chemistry, Clemson University, 467 Hunter Laboratories, Clemson, SC, 29634, USA. falexis@yachaytech.edu.ec.; School of Biological Sciences and Engineering, Yachay Tech, San Miguel de Urcuquí, Ecuador. falexis@yachaytech.edu.ec.

Publikováno v: Scientific reports [Sci Rep] 2020 Jan 30; Vol. 10 (1), pp. 1508. Date of Electronic Publication: 2020 Jan 30.

Poly(amine) modified kaolinite clay for VOC capture.

Autor: Swasy MI; Department of Chemistry, Clemson University, Clemson, SC 29634, USA., Campbell ML; Department of Chemistry, Clemson University, Clemson, SC 29634, USA., Brummel BR; Department of Chemistry, Clemson University, Clemson, SC 29634, USA., Guerra FD; Department of Bioengineering, Clemson University, Clemson, SC 29634, USA., Attia MF; Department of Chemistry, Clemson University, Clemson, SC 29634, USA., Smith GD Jr; Baker Commodities, Inc., Vernon, CA 90058, USA., Alexis F; Department of Bioengineering, Clemson University, Clemson, SC 29634, USA; School of Biological Sciences and Engineering, Yachay Tech, San Miguel de Urcuquí, Ecuador. Electronic address: falexis@yachaytech.edu.ec., Whitehead DC; Department of Chemistry, Clemson University, Clemson, SC 29634, USA. Electronic address: dwhiteh@clemson.edu.

Publikováno v: Chemosphere [Chemosphere] 2018 Dec; Vol. 213, pp. 19-24. Date of Electronic Publication: 2018 Sep 04.