Guselkumab treatment normalizes the stratum corneum ceramide profile and alleviates barrier dysfunction in psoriasis: results of a randomized controlled trial.

Autor: Rousel J; Centre for Human Drug Research, Leiden, The Netherlands; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Mergen C; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Bergmans ME; Centre for Human Drug Research, Leiden, The Netherlands; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands., Bruijnincx LJ; Centre for Human Drug Research, Leiden, The Netherlands., de Kam ML; Centre for Human Drug Research, Leiden, The Netherlands., Klarenbeek NB; Centre for Human Drug Research, Leiden, The Netherlands., Niemeyer-van der Kolk T; Centre for Human Drug Research, Leiden, The Netherlands., van Doorn MBA; Centre for Human Drug Research, Leiden, The Netherlands; Department of Dermatology, Erasmus Medical Centre, Rotterdam, The Netherlands., Bouwstra JA; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands., Rissmann R; Centre for Human Drug Research, Leiden, The Netherlands; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: rrissmann@chdr.nl.

Publikováno v: Journal of lipid research [J Lipid Res] 2024 Aug; Vol. 65 (8), pp. 100591. Date of Electronic Publication: 2024 Jul 09.