PI(4,5)P 2 -stimulated positive feedback drives the recruitment of Dishevelled to Frizzled in Wnt-β-catenin signaling.

Autor: Mahoney JP; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA., Bruguera ES; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA., Vasishtha M; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA., Killingsworth LB; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA., Kyaw S; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA., Weis WI; Departments of Structural Biology and Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94035, USA.

Publikováno v: Science signaling [Sci Signal] 2022 Aug 23; Vol. 15 (748), pp. eabo2820. Date of Electronic Publication: 2022 Aug 23.

Structural instability and divergence from conserved residues underlie intracellular retention of mammalian odorant receptors.

Autor: Ikegami K; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710.; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan., de March CA; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710., Nagai MH; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710.; Department of Biochemistry, Universidade de Sao Paulo, Sao Paulo, 05508-000, Brazil., Ghosh S; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA 91010., Do M; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710., Sharma R; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710., Bruguera ES; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710., Lu YE; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710., Fukutani Y; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710.; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan., Vaidehi N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA 91010., Yohda M; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan., Matsunami H; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710; hiroaki.matsunami@duke.edu.; Department of Neurobiology, Duke Institute for Brain Sciences, Duke University, Durham, NC 27710.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 11; Vol. 117 (6), pp. 2957-2967. Date of Electronic Publication: 2020 Jan 23.