Impact of mucositis on oral bioavailability and systemic exposure of ciprofloxacin Gram-negative infection prophylaxis in patients with haematological malignancies.

Autor: van Rhee KP; Department of Clinical Pharmacy Tergooi MC, Hilversum, The Netherlands.; Department of Clinical Pharmacy St Jansdal Hospital, Harderwijk, The Netherlands.; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands., de Vroom SL; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam Infection and Immunity (AI&II), Amsterdam, The Netherlands., van Hest RM; Department of Hospital Pharmacy, Division of Clinical Pharmacology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., van der Linden PD; Department of Clinical Pharmacy Tergooi MC, Hilversum, The Netherlands., Tonino SH; Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Molendijk E; Department of haematology, Radboud University Medical Center, Nijmegen, The Netherlands., Mathôt RAA; Department of Hospital Pharmacy, Division of Clinical Pharmacology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Blijlevens NMA; Department of haematology, Radboud University Medical Center, Nijmegen, The Netherlands., Knibbe CAJ; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands.; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands., Bruggemann RJM; Department of Pharmacy and Radboud Institute of Health Science, Radboud University Medical Center, Nijmegen, The Netherlands.; Radboud University Medical Center, Center for Infectious Diseases, Nijmegen, The Netherlands., Geerlings SE; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam Infection and Immunity (AI&II), Amsterdam, The Netherlands.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2022 Oct 28; Vol. 77 (11), pp. 3069-3076.