Zobrazeno 1 - 10
of 2 243
pro vyhledávání: '"Brugarolas, A. (A.)"'
Purpose: A reliable cancer prognosis model for clear cell renal cell carcinoma (ccRCC) can enhance personalized treatment. We developed a multi-modal ensemble model (MMEM) that integrates pretreatment clinical data, multi-omics data, and histopatholo
Externí odkaz:
http://arxiv.org/abs/2412.07136
Autor:
Jasti, Jay, Zhong, Hua, Panwar, Vandana, Jarmale, Vipul, Miyata, Jeffrey, Carrillo, Deyssy, Christie, Alana, Rakheja, Dinesh, Modrusan, Zora, Kadel III, Edward Ernest, Beig, Niha, Huseni, Mahrukh, Brugarolas, James, Kapur, Payal, Rajaram, Satwik
Predictive biomarkers of treatment response are lacking for metastatic clear cell renal cell carcinoma (ccRCC), a tumor type that is treated with angiogenesis inhibitors, immune checkpoint inhibitors, mTOR inhibitors and a HIF2 inhibitor. The Angiosc
Externí odkaz:
http://arxiv.org/abs/2405.18327
We present BatchGNN, a distributed CPU system that showcases techniques that can be used to efficiently train GNNs on terabyte-sized graphs. It reduces communication overhead with macrobatching in which multiple minibatches' subgraph sampling and fea
Externí odkaz:
http://arxiv.org/abs/2306.13814
Autor:
Pegolotti, Luca, Pfaller, Martin R., Rubio, Natalia L., Ding, Ke, Brufau, Rita Brugarolas, Darve, Eric, Marsden, Alison L.
Reduced-order models based on physics are a popular choice in cardiovascular modeling due to their efficiency, but they may experience reduced accuracy when working with anatomies that contain numerous junctions or pathological conditions. We develop
Externí odkaz:
http://arxiv.org/abs/2303.07310
Publikováno v:
iRADIOLOGY, Vol 2, Iss 3, Pp 339-361 (2024)
Abstract Positron emission tomography (PET) is a noninvasive molecular imaging technique that utilizes biologically active radiolabeled compounds to image biochemical processes. As such, PET can provide important pathophysiological information associ
Externí odkaz:
https://doaj.org/article/4077a0d7880b48b9bcc12d03c97bd2a3
Autor:
Matilde Simoni, Chiara Menegazzi, Cristina Fracassi, Claudia C Biffi, Francesca Genova, Nazario Pio Tenace, Roberta Lucianò, Andrea Raimondi, Carlo Tacchetti, James Brugarolas, Davide Mazza, Rosa Bernardi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1324-1351 (2024)
Abstract Clear-cell renal cell carcinoma (ccRCC), the major subtype of RCC, is frequently diagnosed at late/metastatic stage with 13% 5-year disease-free survival. Functional inactivation of the wild-type p53 protein is implicated in ccRCC therapy re
Externí odkaz:
https://doaj.org/article/943d98c6d7a140ae919de5ddf5a741fd
Autor:
Yang Sun, Sofia Rodríguez-Rangel, Lauren L. Zhang, Jorge E. Sánchez-Rodríguez, Pedro Brugarolas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract 4-aminopyridine (4AP) is a potassium (K+) channel blocker used clinically to improve walking in people with multiple sclerosis (MS). 4AP binds to exposed K+ channels in demyelinated axons, reducing the leakage of intracellular K+ and enhanci
Externí odkaz:
https://doaj.org/article/8a987955fe3a4e0c9171560042454acd
Autor:
Yu-Peng Zhou, Moses Q. Wilks, Maeva Dhaynaut, Nicolas J. Guehl, Danielle R. Vesper, Sung-Hyun Moon, Peter A. Rice, Georges El Fakhri, Marc D. Normandin, Pedro Brugarolas
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [11C]3MeO4AP has shown promise due to
Externí odkaz:
https://doaj.org/article/3d734de69661416e837557c698a2e2cb
Autor:
Agarwal, N. 1, ∗, Brugarolas, J. 2, 3, Ghatalia, P. 4, George, S. 5, Haanen, J.B. 6, Gurney, H. 7, Ravilla, R. 8, Van der Veldt, A. 9, Beuselinck, B. 10, Pokataev, I. 11, Suelmann, B.B.M. 12, Tuthill, M.H. 13, Vaena, D. 14, Zagouri, F. 15, Wu, J. 16, Perini, R.F. 16, Liu, Y. 16, Merchan, J. 17, Atkins, M.B. 18
Publikováno v:
In Annals of Oncology December 2024 35(12):1148-1156
Autor:
Tran, Diem H., Kim, Dohun, Kesavan, Rushendhiran, Brown, Harrison, Dey, Trishna, Soflaee, Mona Hoseini, Vu, Hieu S., Tasdogan, Alpaslan, Guo, Jason, Bezwada, Divya, Al Saad, Houssam, Cai, Feng, Solmonson, Ashley, Rion, Halie, Chabatya, Rawand, Merchant, Salma, Manales, Nathan J., Tcheuyap, Vanina T., Mulkey, Megan, Mathews, Thomas P., Brugarolas, James, Morrison, Sean J., Zhu, Hao, DeBerardinis, Ralph J., Hoxhaj, Gerta
Publikováno v:
In Cell 11 July 2024 187(14):3602-3618