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Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice

Autor: Stroeve, Johanna H M, Brufau, Gemma, Stellaard, Frans, Gonzalez, Frank J, Staels, Bart, Kuipers, Folkert

Publikováno v: In Laboratory Investigation October 2010 90(10):1457-1467

Phytosterols, but not pectin, added to a high-saturated-fat diet modify saturated fatty acid excretion in relation to chain length

Autor: Brufau, Gemma, Canela, Miguel Angel, Rafecas, Magda

Publikováno v: In The Journal of Nutritional Biochemistry 2007 18(9):580-586

Plasma bile acids are not associated with energy metabolism in humans

Autor: Brufau Gemma, Bahr Matthias J, Staels Bart, Claudel Thierry, Ockenga Johann, Böker Klaus HW, Murphy Elizabeth J, Prado Kris, Stellaard Frans, Manns Michael P, Kuipers Folkert, Tietge Uwe JF

Publikováno v: Nutrition & Metabolism, Vol 7, Iss 1, p 73 (2010)

Abstract Bile acids (BA) have recently been shown to increase energy expenditure in mice, but this concept has not been tested in humans. Therefore, we investigated the relationship between plasma BA levels and energy expenditure in humans. Type 2 di

Externí odkaz: https://doaj.org/article/1d7a2407bdca4665baf59cf2b20986ad

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

Autor: Bartuzi, Paulina, Billadeau, Daniel D, Favier, Robert, Rong, Shunxing, Dekker, Daphne, Fedoseienko, Alina, Fieten, Hille, Wijers, Melinde, Levels, Johannes H, Huijkman, Nicolette, Kloosterhuis, Niels, van der Molen, Henk, Brufau, Gemma, Groen, Albert K, Elliott, Alison M, Kuivenhoven, Jan Albert, Plecko, Barbara, Grangl, Gernot, McGaughran, Julie, Horton, Jay D, Burstein, Ezra, Hofker, Marten H, van de Sluis, Bart, Sub Hepatologie, LS Interne geneeskunde, dCSCA RMSC-1, dCSCA AVR

Publikováno v: Nature Communications, 7:10961. Nature Publishing Group
Nature Communications [E], 7. Nature Publishing Group
Nature communications, 7. Nature Publishing Group
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol. Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott–Aldrich syndrome protein and SCAR homolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d0d772ce51e51aba88b348940c2e56
https://doi.org/10.1038/ncomms10961