Perspectives on a flexible strategy for the management of nonregulated bioanalysis.

Autor: Bruenner BA; Bioanalytical Sciences, Amgen, One Amgen Center Dr., Thousand Oaks, CA 91320-1799, USA., Pham RV; Bioanalytical Sciences, Amgen, One Amgen Center Dr., Thousand Oaks, CA 91320-1799, USA., Rufai W; Bioanalytical Sciences, Amgen, One Amgen Center Dr., Thousand Oaks, CA 91320-1799, USA., James CA; Bioanalytical Sciences, Amgen, One Amgen Center Dr., Thousand Oaks, CA 91320-1799, USA.

Publikováno v: Bioanalysis [Bioanalysis] 2023 Feb; Vol. 15 (3), pp. 103-107. Date of Electronic Publication: 2023 Feb 09.

Disubstituted 1-aryl-4-aminopiperidine library synthesis using computational drug design and high-throughput batch and flow technologies.

Autor: Bryan MC; Medicinal Chemistry Research Technologies, ‡Molecular Structure and Characterization, and §Pharmacokinetics and Drug Metabolism, Therapeutic Discovery, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States., Hein CD, Gao H, Xia X, Eastwood H, Bruenner BA, Louie SW, Doherty EM

Publikováno v: ACS combinatorial science [ACS Comb Sci] 2013 Sep 09; Vol. 15 (9), pp. 503-11. Date of Electronic Publication: 2013 Aug 29.

Simultaneous determination of a p38 MAP kinase inhibitor and its amide hydrolyzed metabolite in Cynomolgus monkey plasma by LC-MS/MS, and its application to a toxicokinetic study.

Autor: Akrami A; Department of Pharmacokinetics and Drug Metabolism, Amgen, Thousand Oaks, CA 91320-1799, United States., Hsieh F, Almon V, Bruenner BA, James C, Wong P

Publikováno v: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2011 Jul 15; Vol. 55 (5), pp. 1104-10. Date of Electronic Publication: 2011 Mar 21.

Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration‐QTc analysis.

Autor: Engwall, Michael J.¹ (AUTHOR), Baublits, Joel¹ (AUTHOR), Chandra, Fiona A.² (AUTHOR), Jones, Zack W.² (AUTHOR), Wahlstrom, Jan³ (AUTHOR), Chui, Ray W.¹ (AUTHOR), Vargas, Hugo M.¹ (AUTHOR) hvargas@amgen.com

Publikováno v: CTS: Clinical & Translational Science. Mar2023, Vol. 16 Issue 3, p436-446. 11p.

Building an Understanding of Proteostasis in Reproductive Cells: The Impact of Reactive Carbonyl Species on Protein Fate.

Autor: Smyth, Shannon P., Nixon, Brett, Skerrett-Byrne, David A., Burke, Nathan D., Bromfield, Elizabeth G.

Publikováno v: Antioxidants & Redox Signaling; Aug2024, Vol. 41 Issue 4-6, p296-321, 26p