Functional EPAS1 / HIF2A missense variant is associated with hematocrit in Andean highlanders.

Autor: Lawrence ES; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Gu W; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Bohlender RJ; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Anza-Ramirez C; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Cole AM; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland., Yu JJ; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Hu H; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heinrich EC; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, USA., O'Brien KA; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK., Vasquez CA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Cowan QT; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Bruck PT; Department of Anthropology and Global Health, University of California, San Diego, La Jolla, CA, USA., Mercader K; Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA., Alotaibi M; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA., Long T; Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Sapient Bioanalytics, LLC, San Diego, CA, USA., Hall JE; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Moya EA; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Bauk MA; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Reeves JJ; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Kong MC; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Salem RM; Herbert Wertheim School of Public Health and Longevity Sciences, University of California, San Diego, La Jolla, CA, USA., Vizcardo-Galindo G; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Macarlupu JL; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Figueroa-Mujíca R; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Bermudez D; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Corante N; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Gaio E; Laboratório de Fisiologia Respiratória, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil., Fox KP; Department of Anthropology and Global Health, University of California, San Diego, La Jolla, CA, USA., Salomaa V; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Havulinna AS; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM-HiLIFE), Helsinki, Finland., Murray AJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK., Malhotra A; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Powel FL; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Jain M; Department of Medicine and Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Sapient Bioanalytics, LLC, San Diego, CA, USA., Komor AC; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Cavalleri GL; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland., Huff CD; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Villafuerte FC; Laboratorio de Fisiología Comparada/Fisiología de del Transporte de Oxígeno-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú., Simonson TS; Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

Publikováno v: Science advances [Sci Adv] 2024 Feb 09; Vol. 10 (6), pp. eadj5661. Date of Electronic Publication: 2024 Feb 09.

SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir.

Autor: Mesci P; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America., de Souza JS; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America., Martin-Sancho L; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California, United States of America., Macia A; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America., Saleh A; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America., Yin X; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California, United States of America., Snethlage C; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America., Adams JW; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America., Avansini SH; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America.; Department of Medical Genetics, School of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil., Herai RH; Experimental Multiuser Laboratory (LEM), Graduate Program in Health Sciences (PPGCS), School of Medicine, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, Paraná, Brazil.; Research Department, Lico Kaesemodel Institute (ILK), Curitiba, Paraná, Brazil., Almenar-Queralt A; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America., Pu Y; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California, United States of America., Szeto RA; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America., Goldberg G; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America., Bruck PT; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America., Papes F; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America.; Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Sao Paulo, Brazil., Chanda SK; Immunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California, United States of America., Muotri AR; Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular & Molecular Medicine, School of Medicine, University of California San Diego, La Jolla, California, United States of America.; Center for Academic Research and Training in Anthropogeny (CARTA), University of California San Diego, La Jolla, California, United States of America.; Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, California, United States of America.; Archealization Center, University of California San Diego, La Jolla, California, United States of America.

Publikováno v: PLoS biology [PLoS Biol] 2022 Nov 03; Vol. 20 (11), pp. e3001845. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).

Neoleukin-2 enhances anti-tumour immunity downstream of peptide vaccination targeted by an anti-MHC class II VHH.

Autor: Crowley SJ; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Bruck PT; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Bhuiyan MA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Mitchell-Gears A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; University of Leeds, Leeds, West Yorkshire, UK., Walsh MJ; Program in Virology and Department of Microbiology, Harvard Medical School, Boston, MA, USA., Zhangxu K; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Ali LR; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Jeong HJ; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological and Chemical Engineering, Hongik University, Mapo-gu, Seoul, Korea., Ingram JR; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Knipe DM; Program in Virology and Department of Microbiology, Harvard Medical School, Boston, MA, USA., Ploegh HL; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Dougan M; Department of Medicine, Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Dougan SK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Immunology, Harvard Medical School, Boston, MA, USA.

Publikováno v: Open biology [Open Biol] 2020 Feb; Vol. 10 (2), pp. 190235. Date of Electronic Publication: 2020 Feb 05.

Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer.

Autor: Yasmin-Karim S; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, United States.; Department of Radiation Oncology, Harvard Medical School, Boston, MA, United States., Bruck PT; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, United States., Moreau M; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, United States.; Department of Biology, University of Massachusetts, Lowell, MA, United States., Kunjachan S; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, United States., Chen GZ; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, United States., Kumar R; Electronic Materials Research Institute, Northeastern University, Boston, MA, United States., Grabow S; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, United States.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, United States., Dougan SK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, United States.; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, United States., Ngwa W; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, United States.; Department of Radiation Oncology, Harvard Medical School, Boston, MA, United States.; Department of Biology, University of Massachusetts, Lowell, MA, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2018 Sep 07; Vol. 9, pp. 2030. Date of Electronic Publication: 2018 Sep 07 (Print Publication: 2018).

IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells.

Autor: Clancy-Thompson E; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts., Ali L; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts., Bruck PT; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts., Exley MA; Beth Israel Deaconess Medical Center, Boston, Massachusetts.; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Blumberg RS; Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Dranoff G; Harvard Medical School, Boston, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Dougan M; Harvard Medical School, Boston, Massachusetts. Stephanie_Dougan@dfci.harvard.edu mldougan@partners.org.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts., Dougan SK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts. Stephanie_Dougan@dfci.harvard.edu mldougan@partners.org.; Harvard Medical School, Boston, Massachusetts.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2018 Jan; Vol. 6 (1), pp. 25-35. Date of Electronic Publication: 2017 Nov 29.