Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Bruce Z. Lu"'
Autor:
Nelu Grinberg, Jun Wang, Guisheng Li, Jon C. Lorenz, Joe Johnson, Xiufeng Sun, Heewon Lee, Yongda Zhang, Wenjie Li, Joe Gao, Sanjit Sanyal, Zhulin Tan, Nathan K. Yee, Bruce Z. Lu, Keith R. Fandrick, Jiang-Ping Wu, Chris H. Senanayake, Jonathan T. Reeves, Sonia Rodriguez
Publikováno v:
The Journal of Organic Chemistry. 81:2665-2669
An efficient asymmetric synthesis of 11-β-HSD inhibitor 1 has been accomplished in five linear steps and 53% overall yield, starting from the readily available 3-chloro-1-phenylpropan-1-one. The key feature of the synthesis includes an asymmetric me
Autor:
Nelu Grinberg, Marc-André Poupart, Jon C. Lorenz, Bo Qu, Nizar Haddad, Nina C. Gonnella, Shengli Ma, Nathan K. Yee, Wenjun Tang, Jiang-Ping Wu, Youla S. Tsantrizos, Wenjie Li, Joe Gao, Kanwar Sidhu, June Wang, Nitinchandra D. Patel, Sonia Rodriguez, Sanjit Sanyal, Heewon Lee, Yongda Zhang, Carl A. Busacca, Diana C. Reeves, Bruce Z. Lu, Keith R. Fandrick, Chris H. Senanayake
Publikováno v:
Angewandte Chemie. 127:7250-7254
A practical and efficient synthesis of a complex chiral atropisomeric HIV integrase inhibitor has been accomplished. The combination of a copper-catalyzed acylation along with the implementation of the BI-DIME ligands for a ligand-controlled Suzuki c
Autor:
Kanwar Sidhu, Wenjun Tang, Azad Hossain, Nizar Haddad, Larry Nummy, Heewon Lee, Nathan K. Yee, Bruce Z. Lu, Ajith Premasiri, Xiufeng Sun, Jun Wang, Jolaine Savoie, Wenjie Li, Chris H. Senanayake, Adil Duran, Sonia Rodriguez, Bo Qu, Nitinchandra D. Patel, Jon C. Lorenz
Publikováno v:
Organic Process Research & Development. 17:1061-1065
A highly electron-rich P-chiral bis(trialkylphosphane) ligand MeO-BIBOP (1) was efficiently synthesized on large scale. The MeO-BIBOP–rhodium complex exhibited remarkably high reactivities (up to 200,000 TON) for the hydrogenation of N-acetyl enami
Autor:
Dhileep Krishnamurthy, Shengli Ma, Navneet Goyal, Nelu Grinberg, Zhibin Li, Joshua D. Sieber, Yongda Zhang, Philomen DeCroos, Melissa A. Herbage, Li Zhang, Jonathan T. Reeves, Chris H. Senanayake, Hari P. R. Mangunuru, Ning Li, Guijun Wang, Jinhua J. Song, Xiao-Jun Wang, Zhengxu S. Han, Guisheng Li, Yibo Xu, Bruce Z. Lu
Publikováno v:
Angewandte Chemie International Edition. 52:6713-6717
Autor:
Navneet Goyal, Bruce Z. Lu, Chris H. Senanayake, Heewon Lee, Yongda Zhang, Guisheng Li, Ning Li
Publikováno v:
The Journal of Organic Chemistry. 78:5775-5781
A solvent- and metal-free process has been developed for the direct methallylboration of ketones employing the stable B-methallylborinane 1, which was accelerated by tertiary alcohols. In the presence of 2.0 equiv of readily available tertiary alcoho
Publikováno v:
Journal of Heterocyclic Chemistry. 50:680-683
Various 2-formylazoles underwent CuI/sparteine-catalyzed annulation with 1-substituted-4-iodo-5-aminopyrazoles to produce four new heterocyclic ring systems. The reaction was demonstrated for 2-formylpyrroles, 2-formylindoles, 2-formylimidazole, and
Autor:
Guisheng Li, Hanxun Wei, Yongda Zhang, Chris H. Senanayake, Bruce Z. Lu, Marine Dufour, Wenyi Zhao, Vittorio Farina
Publikováno v:
The Journal of Organic Chemistry. 78:4558-4562
A practical one-pot and regiospecific three-component process for the synthesis of 2,3-disubstituted indoles from 2-bromoanilides was developed via consecutive palladium-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.
Autor:
Dajun Chen, Bo Qu, Bruce Z. Lu, Carl A. Busacca, Keith R. Fandrick, Nicole Grět, Anjan Saha, Yaping Hong, Zhibin Li, Nizar Haddad, Diana C. Reeves, Shengli Ma, Jiang Ping Wu, Chris H. Senanayake, Magnus C. Eriksson, Heewon Lee, Nelu Grinberg, Maurice A. Marsini
Publikováno v:
Advanced Synthesis & Catalysis. 355:1455-1463
The modular nature of the BIPI ligands allows for systematic optimization of each ligand region. The development of ligands optimized for asymmetric hydrogenation of the challenging unfunctionalized olefin substrate class is described. The naphthyl p
Autor:
Nathan K. Yee, Magnus C. Eriksson, Vittorio Farina, Jianxu Liu, Chris H. Senanayake, Jinhua J. Song, Zhulin Tan, Guisheng Li, Sonia Rodriguez, Bruce Z. Lu
Publikováno v:
Synlett. 24:317-322
The development of synthetic routes to 4-[6-(morpholinomethyl)pyridin-3-yl]naphthalen-1-amine, the key intermediate of p38 MAP kinase inhibitor BIRB 1017, via (1) trialkylmagnesium ate complex mediated metalation and borylation followed by Suzuki cou
Autor:
Diana C. Reeves, Bruce Z. Lu, Jonathan T. Reeves, Zhengxu S. Han, Yibo Xu, Heewon Lee, Zhulin Tan, Chris H. Senanayake, Maurice A. Marsini
Publikováno v:
Advanced Synthesis & Catalysis. 355:47-52
A mild and general procedure for reduction of primary, secondary, and tertiary amides using catalytic triruthenium dodecacarbonyl and 1,1,3,3-tetramethyldisiloxane as reductant is described. The reaction is tolerant of numerous functional groups, and