Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Bruce Whitelaw"'
Autor:
Wenfang S Tan, Enguang Rong, Inga Dry, Simon G Lillico, Andy Law, Paul Digard, Bruce Whitelaw, Robert G Dalziel
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011822 (2023)
The advances in gene editing bring unprecedented opportunities in high throughput functional genomics to animal research. Here we describe a genome wide CRISPR knockout library, btCRISPRko.v1, targeting all protein coding genes in the cattle genome.
Externí odkaz:
https://doaj.org/article/9b23bb4e4bcd4b9fa5e52e039bc09552
Autor:
Wenfang Spring Tan, Enguang Rong, Inga Dry, Simon Lillico, Andy Law, Paul Digard, Bruce Whitelaw, Robert G. Dalziel
Publikováno v:
Viruses, Vol 16, Iss 2, p 297 (2024)
To identify host factors that affect Bovine Herpes Virus Type 1 (BoHV-1) infection we previously applied a genome wide CRISPR knockout screen targeting all bovine protein coding genes. By doing so we compiled a list of both pro-viral and anti-viral p
Externí odkaz:
https://doaj.org/article/92554c5a6aef4e69a1b87f7073f7b160
Autor:
Luise A. Seeker, Sarah L. Underwood, Rachael V. Wilbourn, Jennifer Dorrens, Hannah Froy, Rebecca Holland, Joanna J. Ilska, Androniki Psifidi, Ainsley Bagnall, Bruce Whitelaw, Mike Coffey, Georgios Banos, Daniel H. Nussey
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Telomere length is predictive of adult health and survival across vertebrate species. However, we currently do not know whether such associations result from among-individual differences in telomere length determined genetically or by early-
Externí odkaz:
https://doaj.org/article/ab6c6709e3b64eb4a9068e831fb649dc
Autor:
Tuanjun Hu, Lorna Taylor, Adrian Sherman, Christian Keambou Tiambo, Steven J Kemp, Bruce Whitelaw, Rachel J Hawken, Appolinaire Djikeng, Michael J McGrew
Publikováno v:
eLife, Vol 11 (2022)
Chickens are an important resource for smallholder farmers who raise locally adapted, genetically distinct breeds for eggs and meat. The development of efficient reproductive technologies to conserve and regenerate chicken breeds safeguards existing
Externí odkaz:
https://doaj.org/article/280478cb69a440619071a94879529e89
Autor:
Ryan Phelan, Bridget Baumgartner, Stewart Brand, Evelyn Brister, Stanley W. Burgiel, R. Alta Charo, Isabelle Coche, Al Cofrancesco, Jason A. Delborne, Owain Edwards, Joshua P. Fisher, Martin Gaywood, Doria R. Gordon, Gregg Howald, Margaret E. Hunter, Peter Kareiva, Aditi Mankad, Michelle Marvier, Katherine Moseby, Andrew E. Newhouse, Ben J. Novak, Gerry Ohrstrom, Steven Olson, Megan J. Palmer, Stephen Palumbi, Neil Patterson Jr., Miguel Pedrono, Francisco Pelegri, Yasha Rohwer, Oliver A. Ryder, J. Royden Saah, Robert M. Scheller, Philip J. Seddon, H. Bradley Shaffer, Beth Shapiro, Mike Sweeney, Mark R. Tercek, Delphine Thizy, Whitney Tilt, Michele Weber, Renee D. Wegrzyn, Bruce Whitelaw, Matthew Winkler, Josh Wodak, Mark Zimring, Paul Robbins
Publikováno v:
Conservation Science and Practice, Vol 3, Iss 4, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/ac1707b90f504597a713b6b4d84dcfda
The Genetic Architecture of Bovine Telomere Length in Early Life and Association With Animal Fitness
Autor:
Joanna J. Ilska-Warner, Androniki Psifidi, Luise A. Seeker, Rachael V. Wilbourn, Sarah L. Underwood, Jennifer Fairlie, Bruce Whitelaw, Daniel H. Nussey, Mike P. Coffey, Georgios Banos
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Health and survival are key goals for selective breeding in farm animals. Progress, however, is often limited by the low heritability of these animal fitness traits in addition to measurement difficulties. In this respect, relevant early-life biomark
Externí odkaz:
https://doaj.org/article/8fbf580e719f4a69aac690a85f085603
Autor:
Luise A Seeker, Joanna J Ilska, Androniki Psifidi, Rachael V Wilbourn, Sarah L Underwood, Jennifer Fairlie, Rebecca Holland, Hannah Froy, Ainsley Bagnall, Bruce Whitelaw, Mike Coffey, Daniel H Nussey, Georgios Banos
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192864 (2018)
Telomeres cap the ends of linear chromosomes and shorten with age in many organisms. In humans short telomeres have been linked to morbidity and mortality. With the accumulation of longitudinal datasets the focus shifts from investigating telomere le
Externí odkaz:
https://doaj.org/article/4f77cfe62bd9439890bc0c71719bfe44
Autor:
Luise A Seeker, Rebecca Holland, Sarah Underwood, Jennifer Fairlie, Androniki Psifidi, Joanna J Ilska, Ainsley Bagnall, Bruce Whitelaw, Mike Coffey, Georgios Banos, Daniel H Nussey
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164046 (2016)
Telomere length (TL) is increasingly being used as a biomarker in epidemiological, biomedical and ecological studies. A wide range of DNA extraction techniques have been used in telomere experiments and recent quantitative PCR (qPCR) based studies su
Externí odkaz:
https://doaj.org/article/28bc0e660fb945378893e62e9c832e37
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
The development of macrophages requires signaling through the lineage-restricted receptor Csf1r. Macrophage-restricted expression of transgenic reporters based upon Csf1r requires the highly conserved Fms-intronic regulatory element (FIRE). We have c
Externí odkaz:
https://doaj.org/article/a0a2eaf47bff499d9b2c94f20e80621f
Publikováno v:
McFarlane, G, Lillico, S & Whitelaw, B 2023, ' Gene drive: past, present and future roads to vertebrate biocontrol ', MDPI Applied Biosciences, vol. 2, no. 1, pp. 52-70 . https://doi.org/10.3390/applbiosci2010006
Scientists have long sought a technology to humanely control populations of damaging invasive pests in a species-specific manner. Gene drive technology could see this become a reality. This review charts the twists and turns on the road to developing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4430254990e51588b519d8803a1497e6
https://www.pure.ed.ac.uk/ws/files/325503850/Gene_drive_past_present_and_future_mdpi_v2.docx
https://www.pure.ed.ac.uk/ws/files/325503850/Gene_drive_past_present_and_future_mdpi_v2.docx
