Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Bruce W. S. Robinson"'
Autor:
Scott A. Fisher, Kimberley Patrick, Tracy Hoang, Elly Marcq, Kiarash Behrouzfar, Sylvia Young, Timothy J. Miller, Bruce W. S. Robinson, Raphael Bueno, Anna K. Nowak, W. Joost Lesterhuis, Grant Morahan, Richard A. Lake
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Objectives: This study combines two innovative mouse models in a major gene discovery project to assess the influence of host genetics on asbestos related disease (ARD). Conventional genetics studies provided evidence that some susceptibility to meso
Externí odkaz:
https://doaj.org/article/3d44dba5e34544bab7bb7980e494ea5c
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The process of tumorigenesis leaves a series of indelible genetic changes in tumor cells, that when expressed, have the potential to be tumor-specific immune targets. Neoantigen vaccines that capitalize on this potential immunogenicity have shown eff
Externí odkaz:
https://doaj.org/article/a780f4b74b8047b38636d05a536d5177
Publikováno v:
Vaccines, Vol 10, Iss 6, p 951 (2022)
During the current pandemic, the vast majority of COVID-19 patients experienced mild symptoms, but some had a potentially fatal aberrant hyperinflammatory immune reaction characterized by high levels of IL-6 and other cytokines. Modulation of this im
Externí odkaz:
https://doaj.org/article/5b8d58e104c0440694fda09620734602
Autor:
Qingzhu Jia, Luting Chiu, Shuangxiu Wu, Jian Bai, Lina Peng, Linpeng Zheng, Rui Zang, Xueqin Li, Bibo Yuan, Yixing Gao, Dingyong Wu, Xiaohong Li, Lin Wu, Jianguo Sun, Ji He, Bruce W. S. Robinson, Bo Zhu
Publikováno v:
Advanced Science, Vol 7, Iss 9, Pp n/a-n/a (2020)
Abstract The evolutionary dynamics of tumor‐associated neoantigens carry information about drug sensitivity and resistance to the immune checkpoint blockade (ICB). However, the spectrum of somatic mutations is highly heterogeneous among patients, m
Externí odkaz:
https://doaj.org/article/ea92758f1c834e01a479b3d623e7ee12
Autor:
Shaokang Ma, Jonathan Chee, Vanessa S. Fear, Catherine A. Forbes, Louis Boon, Ian M. Dick, Bruce W. S. Robinson, Jenette Creaney
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Immune checkpoint blockade (ICPB) is a powerfully effective cancer therapy in some patients. Tumor neo-antigens are likely main targets for attack but it is not clear which and how many tumor mutations in individual cancers are actually antigenic, wi
Externí odkaz:
https://doaj.org/article/23ce837661e44aeeb25ccff5899e605b
Autor:
Sophie Sneddon, Craig M. Rive, Shaokang Ma, Ian M. Dick, Richard J. N. Allcock, Scott D. Brown, Robert A. Holt, Mark Watson, Shay Leary, Y. C. Gary Lee, Bruce W. S. Robinson, Jenette Creaney
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Neoantigens present unique and specific targets for personalized cancer immunotherapy strategies. Given the low mutational burden yet immunotherapy responsiveness of malignant mesothelioma (MM) when compared to other carcinogen-induced malignancies,
Externí odkaz:
https://doaj.org/article/a5c3676684ef4ac482301493794830e6
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-15 (2017)
Abstract Background CD40 signalling can synergise with chemotherapy in preclinical cancer models, and early clinical studies are promising. We set out to define the immunological changes associated with this therapeutic combination to identify biomar
Externí odkaz:
https://doaj.org/article/ce8c9ba91b084192b71b0efaac8e4c66
Autor:
Sophie Sneddon, Ann-Marie Patch, Ian M. Dick, Stephen Kazakoff, John V. Pearson, Nicola Waddell, Richard J. N. Allcock, Robert A. Holt, Bruce W. S. Robinson, Jenette Creaney
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Malignant mesothelioma (MM) is an aggressive cancer of the pleural and peritoneal cavities caused by exposure to asbestos. Asbestos-induced mesotheliomas in wild-type mice have been used extensively as a preclinical model because
Externí odkaz:
https://doaj.org/article/32165406f89a4712915a54c298161b4d
Autor:
Georg Johnen, Katarzyna Gawrych, Irina Raiko, Swaantje Casjens, Beate Pesch, Daniel G. Weber, Dirk Taeger, Martin Lehnert, Jens Kollmeier, Torsten Bauer, Arthur W. Musk, Bruce W. S. Robinson, Thomas Brüning, Jenette Creaney
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background Malignant mesothelioma (MM) is a deadly cancer mainly caused by previous exposure to asbestos. With a latency period up to 50 years the incidence of MM is still increasing, even in countries that banned asbestos. Secondary prevent
Externí odkaz:
https://doaj.org/article/f001141541964964be7a2c1955358522
Publikováno v:
Clinical and Developmental Immunology, Vol 2010 (2010)
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hos
Externí odkaz:
https://doaj.org/article/427513eeb9a740e4abbf007fc3facd05