Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Bruce W, Patterson"'
Autor:
Baohai Shao, Masami Shimizu-Albergine, Farah Kramer, Jenny E. Kanter, Jay W. Heinecke, Tomas Vaisar, Bettina Mittendorfer, Bruce W. Patterson, Karin E. Bornfeldt
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 4, Pp 100531- (2024)
Altered apolipoprotein kinetics play a critical role in promoting dyslipidemia and atherogenesis. Human apolipoprotein kinetics have been extensively evaluated, but similar studies in mice are hampered by the lack of robust methods suitable for the s
Externí odkaz:
https://doaj.org/article/eb7bb67902ae41f8935f1f4dd33cf409
Autor:
Cindy V. Ly, Margaret D. Ireland, Wade K. Self, James Bollinger, Jennifer Jockel‐Balsarotti, Hillary Herzog, Peggy Allred, Leah Miller, Michael Doyle, Isabel Anez‐Bruzual, Bhavesh Trikamji, Ted Hyman, Tyler Kung, Katherine Nicholson, Robert C. Bucelli, Bruce W. Patterson, Randall J. Bateman, Timothy M. Miller
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 6, Pp 1012-1024 (2023)
Abstract Objective Accumulation of misfolded superoxide dismutase‐1 (SOD1) is a pathological hallmark of SOD1‐related amyotrophic lateral sclerosis (ALS) and is observed in sporadic ALS where its role in pathogenesis is controversial. Understandi
Externí odkaz:
https://doaj.org/article/98d42917dba74305a8348d97ae76c0a0
Autor:
Bettina Mittendorfer, Brandon D. Kayser, Mihoko Yoshino, Jun Yoshino, Jeramie D. Watrous, Mohit Jain, J. Christopher Eagon, Bruce W. Patterson, Samuel Klein
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
BACKGROUND There is considerable heterogeneity in the effect of weight loss on metabolic function in people with obesity.METHODS We evaluated muscle and liver insulin sensitivity, body composition, and circulating factors associated with insulin acti
Externí odkaz:
https://doaj.org/article/23ffeddd40944b2ab447bedb3aaf9757
Autor:
Bettina Mittendorfer, Bruce W. Patterson, Faidon Magkos, Mihoko Yoshino, David P. Bradley, J. Christopher Eagon, Samuel Klein
Publikováno v:
JCI Insight, Vol 8, Iss 12 (2023)
Background The effects of diet-induced weight loss (WL) and WL after Roux-en-Y gastric bypass (RYGB) surgery on β cell function (BCF) are unclear because of conflicting results from different studies, presumably because of differences in the methods
Externí odkaz:
https://doaj.org/article/b66c3996a3664d42a67ddd6535d8e5ea
Autor:
Donald L. Elbert, Bruce W. Patterson, Brendan P. Lucey, Tammie L. S. Benzinger, Randall J. Bateman
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
To understand if brain interstitial fluid/cerebrospinal fluid (ISF/CSF) exchange, CSF turnover, blood-brain barrier function or proteolysis were affected by aging or the presence of β amyloid plaques, Elbert et al. develop a non-steady state physiol
Externí odkaz:
https://doaj.org/article/1397e8989a1a46599ec580bb8461d542
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Background It is unclear how excess adiposity and insulin resistance affect β cell function, insulin secretion, and insulin clearance in people with obesity.Methods We used a hyperinsulinemic-euglycemic clamp procedure and a modified oral glucose to
Externí odkaz:
https://doaj.org/article/08c03347e8d948b6ac7c26eb2de742a0
Autor:
W. Todd Cade, Kathryn L. Bohnert, Adam J. Bittel, Shaji J. Chacko, Bruce W. Patterson, Christina A. Pacak, Barry J. Byrne, Hilary J. Vernon, Dominic N. Reeds
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 25, Iss , Pp 100675- (2020)
Barth syndrome (BTHS) is a rare, X-linked cardiomyopathy that is characterized by abnormalities in glucose and lipid metabolism, with less known regarding amino acid metabolism. This pilot study characterized whole-body arginine kinetics and found lo
Externí odkaz:
https://doaj.org/article/925992a8f07247c387572895a3a12948
Autor:
Mohamed A. Zayed, Fong-Fu Hsu, Bruce W. Patterson, Yan Yan, Uzma Naim, Malik Darwesh, Gayan De Silva, Chao Yang, Clay F. Semenkovich
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 4, Pp 730-738 (2018)
Patients with diabetes are at higher risk of developing carotid artery stenosis and resultant stroke. Arachidonoyl phospholipids affect plaque inflammation and vulnerability, but whether diabetic patients have unique carotid artery phospholipidomic p
Externí odkaz:
https://doaj.org/article/e9917d54858249cf88dbc3ddb3ed7beb
Publikováno v:
European Journal of Endocrinology. 187:391-398
Objective Increased triglyceride (TG) and apolipoprotein B-100 (apoB-100) concentrations in plasma are important risk factors for cardiovascular disease in women. Administration of some estrogen preparations raises plasma TG and apoB-100 concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd9c2d947b835087ebd33ab2519d412
https://doi.org/10.1530/eje-22-0410
https://doi.org/10.1530/eje-22-0410
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0212738 (2019)
We aim to identify physiologic regulators of dopamine (DA) signaling in obesity but previously did not find a compelling relationship with insulin sensitivity measured by oral-minimal model (OMM) and DA subtype 2 and 3 receptor (D2/3R) binding potent
Externí odkaz:
https://doaj.org/article/1120a81453934a88af281e7e1173a7da