Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis

Autor: Vipavee Niemsiri, Sara Brin Rosenthal, Caroline M. Nievergelt, Adam X. Maihofer, Maria C. Marchetto, Renata Santos, Tatyana Shekhtman, Ney Alliey-Rodriguez, Amit Anand, Yokesh Balaraman, Wade H. Berrettini, Holli Bertram, Katherine E. Burdick, Joseph R. Calabrese, Cynthia V. Calkin, Carla Conroy, William H. Coryell, Anna DeModena, Lisa T. Eyler, Scott Feeder, Carrie Fisher, Nicole Frazier, Mark A. Frye, Keming Gao, Julie Garnham, Elliot S. Gershon, Fernando S. Goes, Toyomi Goto, Gloria J. Harrington, Petter Jakobsen, Masoud Kamali, Marisa Kelly, Susan G. Leckband, Falk W. Lohoff, Michael J. McCarthy, Melvin G. McInnis, David Craig, Caitlin E. Millett, Francis Mondimore, Gunnar Morken, John I. Nurnberger, Claire O’ Donovan, Ketil J. Øedegaard, Kelly Ryan, Martha Schinagle, Paul D. Shilling, Claire Slaney, Emma K. Stapp, Andrea Stautland, Bruce Tarwater, Peter P. Zandi, Martin Alda, Kathleen M. Fisch, Fred H. Gage, John R. Kelsoe

Publikováno v: Molecular Psychiatry

Lithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional genes and pathways that distinguish BD Li r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dddb213b88beb2e71651d5b38d3a693
https://hdl.handle.net/11250/3076447

Clinical predictors of non-response to lithium treatment in the Pharmacogenomics of Bipolar Disorder (PGBD) study

Autor: Paul D. Shilling, John I. Nurnberger, Michael McCarthy, Martin Alda, Megan Ritchey, Wade H. Berrettini, Vigdis Elin Giever Syrstad, Cynthia V. Calkin, Peter P. Zandi, Gloria Harrington, Fernando S. Goes, William Coryell, Elliot S. Gershon, Yokesh Balaraman, Toyomi Goto, Elizabeth Karberg, Abesh Kumar Bhattacharjee, Joseph R. Calabrese, Bruce Tarwater, Caroline M. Nievergelt, Helle K. Schoeyen, Kelly A. Ryan, John R. Kelsoe, Joanna M. Biernacka, Julie Garnham, Masoud Kamali, Kara Glazer, Falk W. Lohoff, Francis M. Mondimore, Gunnar Morken, Yian Lin, Ney Alliey-Rodriguez, Mark A. Frye, Nicole Frazier, Petter Jakobsen, Marth Shaw, Ole A. Andreassen, Melvin G. McInnis, Adam X. Maihofer, Martha Schinagle, Emma K. Stapp, Susan G. Leckband, Keming Gao, Amit Anand, Carrie Fisher, Marisa Kelly, Claire Slaney, Andrea Stautland, Carla Conroy, Ketil J. Oedegaard, Anna DeModena, Nicole D'Arcangelo, Holli Bertram

Publikováno v: Bipolar Disorders

Background Lithium is regarded as a first-line treatment for bipolar disorder (BD), but partial response and non-response commonly occurs. There exists a need to identify lithium non-responders prior to initiating treatment. The Pharmacogenomics of B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d7bb7e93e92fc2550142370e33ba30
https://pubmed.ncbi.nlm.nih.gov/33797828

Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder

Autor: Yokesh Balaraman, Gloria Harrington, Julie Garnham, Petter Jakobsen, David K. Welsh, Szabolcs Szelinger, Martin Alda, Ney Alliey-Rodriguez, Susan G. Leckband, Ole A. Andreasson, Nicole Frazier, Abigail Ortiz, Clara Conroy, Holli Bertram, Marisa Kelly, Sarah Obral, Joseph R. Calabrese, Bruce Tarwater, Claire Slaney, Andrea Stautland, Paul D. Shilling, David Craig, Candice L. Schwebel, Cynthia V. Calkin, Scott E. Feeder, Toyomi Goto, Emma K. Stapp, Heather Wei, Elizabeth Karberg, Caroline M. Nievergelt, Melvin G. McInnis, Anna DeModena, Nicole D'Arcangelo, Kelly A. Ryan, Wade H. Berrettini, Peter P. Zandi, Keming Gao, Martha Schinagle, Michael McCarthy, Ana M. Claasen, Ketil J. Oedegaard, John I. Nurnberger, Megan Ritchey, Kristen J. Brennand, Carrie Fisher, Mark A. Frye, Fred H. Gage, John R. Kelsoe, Gunnar Morken, Fernando S. Goes, Masoud Kamali, Francis M. Mondimore, Adam X. Maihofer, Amit Anand, Tatyana Shekhtman, William Coryell, Kara Glazer, Martha Shaw, Elliot S. Gershon, Falk W. Lohoff, Srdjan Djurovic, Helle K. Schoeyen

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 44, iss 3
620–628
Neuropsychopharmacology

Bipolar disorder (BD) is a serious mood disorder associated with circadian rhythm abnormalities. Risk for BD is genetically encoded and overlaps with systems that maintain circadian rhythms. Lithium is an effective mood stabilizer treatment for BD, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ac0de8c87a672d8a9195e28864ff78
https://escholarship.org/uc/item/0p95j75v