Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Bruce T. Schaar"'
Autor:
Michael Hiller, Bruce T. Schaar, Vahan B. Indjeian, David M. Kingsley, Lee R. Hagey, Gill Bejerano
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 817-823 (2012)
Genotype-phenotype mapping is hampered by countless genomic changes between species. We introduce a computational “forward genomics” strategy that—given only an independently lost phenotype and whole genomes—matches genomic and phenotypic los
Externí odkaz:
https://doaj.org/article/0c0f5bb7305e429abe00bf0c5ea37e0b
Autor:
Aaron M Wenger, Shoa L Clarke, James H Notwell, Tisha Chung, Geetu Tuteja, Harendra Guturu, Bruce T Schaar, Gill Bejerano
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003728 (2013)
Genetic studies have identified a core set of transcription factors and target genes that control the development of the neocortex, the region of the human brain responsible for higher cognition. The specific regulatory interactions between these fac
Externí odkaz:
https://doaj.org/article/61e67825023547149a08a738e44df681
Autor:
Ann K. Folkins, Kalika Kamat, Vinita Parkash, Yue Zhang, Sonia Patel, Supreeti Tallapragada, Anita M. Chanana, Oliver Dorigo, Bruce T. Schaar, Carrie W. Rinker-Schaeffer, Erinn B. Rankin, Venkatesh Krishnan
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology
Communications Biology
The omentum is the most common site of ovarian cancer metastasis. Immune cell clusters called milky spots are found throughout the omentum. It is however unknown if these immune cells contribute to ovarian cancer metastasis. Here we report that oment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a93c173956bfda112d649defbbcada2
https://doi.org/10.1038/s42003-020-01246-z
https://doi.org/10.1038/s42003-020-01246-z
Autor:
Shoa L Clarke, Julia E VanderMeer, Aaron M Wenger, Bruce T Schaar, Nadav Ahituv, Gill Bejerano
Publikováno v:
PLoS Genetics, Vol 8, Iss 8, p e1002852 (2012)
The identification of homologies, whether morphological, molecular, or genetic, is fundamental to our understanding of common biological principles. Homologies bridging the great divide between deuterostomes and protostomes have served as the basis f
Externí odkaz:
https://doaj.org/article/00c7ff31553145218156c771be3637ad
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17802 (2011)
Newborn neurons migrate from their birthplace to their final location to form a properly functioning nervous system. During these movements, young neurons must attach and subsequently detach from their substrate to facilitate migration, but little is
Externí odkaz:
https://doaj.org/article/1c55dd957444455ca1434eeadd50cf6f
Publikováno v:
Current opinion in obstetricsgynecology. 31(1)
To provide an overview of the principles, safety and efficacy of adoptive cell therapy (ACT) in solid tumors particularly in gynecological cancers.Efforts to target solid tumors using tumor-infiltrating lymphocytes and genetically modified T cells ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10e271a23ba3a82340d7d1d51984824
https://pubmed.ncbi.nlm.nih.gov/30540582
https://pubmed.ncbi.nlm.nih.gov/30540582
Autor:
Masamitsu Kanada, Christopher H. Contag, Huanhuan He, Oliver Dorigo, Bruce T. Schaar, Alan Chiu, Venkatesh Krishnan
Publikováno v:
Molecular imaging and biology. 19(5)
Tumor-associated macrophages (TAMs) are often associated with a poor prognosis in cancer. To gain a better understanding of cellular recruitment and dynamics of TAM biology during cancer progression, we established a novel transgenic mouse model for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c521f9cc0f59090d974d0972c5709e
https://pubmed.ncbi.nlm.nih.gov/28233218
https://pubmed.ncbi.nlm.nih.gov/28233218
Autor:
Oliver Dorigo, Carrie W. Rinker-Schaeffer, Bruce T. Schaar, Anita M. Chanana, Supreeti Tallapragada, Venkatesh Krishnan
Publikováno v:
Clinical Cancer Research. 25:TMIM-076
BACKGROUND: Metastatic ovarian cancer remains an urgent clinical problem. The homing and invasion of cancer cells into the omental adipose tissue, which is the preferred site of ovarian cancer metastasis, is a critical step in disease progression. Om
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc2976d0b23f5f6c71a0b61d040c02b
https://doi.org/10.1158/1557-3265.ovcasymp18-tmim-076
https://doi.org/10.1158/1557-3265.ovcasymp18-tmim-076
Autor:
Gill Bejerano, Bruce T. Schaar, Aaron M. Wenger, Shoa L. Clarke, Harendra Guturu, Jenny Chen, Cory Y. McLean
Publikováno v:
Genome Research. 23:889-904
The human genome encodes 1500–2000 different transcription factors (TFs). ChIP-seq is revealing the global binding profiles of a fraction of TFs in a fraction of their biological contexts. These data show that the majority of TFs bind directly next
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b40587d2e14b5fc521728cb33251f514
https://doi.org/10.1101/gr.139071.112
https://doi.org/10.1101/gr.139071.112
Publikováno v:
Nucleic Acids Research
Conserved non-protein-coding DNA elements (CNEs) often encode cis-regulatory elements and are rarely lost during evolution. However, CNE losses that do occur can be associated with phenotypic changes, exemplified by pelvic spine loss in sticklebacks.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d99ae8b8e2ab74379dcc3949e18a819
https://doi.org/10.1093/nar/gks905
https://doi.org/10.1093/nar/gks905