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Autor:
George B. Mullen, Robert A. Mack, Anthony Sampognaro, John Macor, Patrick Verhoest, Bruce Shepardson
Publikováno v:
The Journal of Organic Chemistry. 69:6493-6495
A direct, short chiral synthesis of the selective alpha7 nicotinic receptor agonist (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one] (AR-R17779) is presented. The key step utilized attack of the dianion of the (R)-HYTRA ester [(R)-(+)-2-hy