Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Bruce S. Edwards"'
Autor:
David Barrett, Meghan Wyatt, Haim Bar, Mark K. Haynes, Bruce S. Edwards, Larry A. Sklar, Adam Zweifach
Publikováno v:
SLAS Discovery, Vol 27, Iss 5, Pp 314-322 (2022)
The solid tumor microenvironment (TME) suppresses immune responses. Three alterations in the TME converge on a pathway triggered by elevated cyclic AMP (cAMP) that suppresses T cell receptor (TCR) signaling. We developed a phenotypic assay to screen
Externí odkaz:
https://doaj.org/article/cd239189b37c4c4296a91e5340d47196
Autor:
Richard A. Houghten, Larry A. Sklar, Bruce S. Edwards, Marc A. Giulianotti, Jon R. Appel, Radleigh G. Santos, Clemencia Pinilla
Publikováno v:
Molecules, Vol 18, Iss 6, Pp 6408-6424 (2013)
In the past 20 years, synthetic combinatorial methods have fundamentally advanced the ability to synthesize and screen large numbers of compounds for drug discovery and basic research. Mixture-based libraries and positional scanning deconvolution com
Externí odkaz:
https://doaj.org/article/b974e2ed0f72410596a318605633433d
Autor:
Erin K Sully, Natalia Malachowa, Bradley O Elmore, Susan M Alexander, Jon K Femling, Brian M Gray, Frank R DeLeo, Michael Otto, Ambrose L Cheung, Bruce S Edwards, Larry A Sklar, Alexander R Horswill, Pamela R Hall, Hattie D Gresham
Publikováno v:
PLoS Pathogens, Vol 10, Iss 6, p e1004174 (2014)
Bacterial signaling systems are prime drug targets for combating the global health threat of antibiotic resistant bacterial infections including those caused by Staphylococcus aureus. S. aureus is the primary cause of acute bacterial skin and soft ti
Externí odkaz:
https://doaj.org/article/fdf762f825264e0283ee04c5cecab9c9
Autor:
Oleg Ursu, Yinan Wang, Anna Waller, Larry A. Sklar, Barry P. Sleckman, Andrea L. Bredemeyer, Mark K. Haynes, Bruce S. Edwards, Abigail J Morales
Publikováno v:
SLAS Discovery. 23:624-633
DNA double strand breaks (DSBs) are repaired primarily by homologous recombination (HR) or non-homologous end joining (NHEJ). Compounds that modulate HR have shown promise as cancer therapeutics. The V(D)J recombination reaction, which assembles anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18732b07d8808bdfd39207eb985a0368
https://doi.org/10.1177/2472555217746324
https://doi.org/10.1177/2472555217746324
Autor:
Virginie Bondu, Catherine E. Prudom Gineste, Bruce S. Edwards, Yang Wu, Larry A. Sklar, Dominique Perez, Tione Buranda, Kaylin R Lake
Publikováno v:
SLAS Discovery. 23:634-645
Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), which infects over 200,000 people worldwide. Sin Nombre virus (SNV) and Andes virus (ANDV) cause the most severe form of HCPS with case fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314f6d16a015cf2d0511be428e4cda5a
https://doi.org/10.1177/2472555218766623
https://doi.org/10.1177/2472555218766623
Autor:
Bruce S. Edwards, Frank A. Fencl, Gian C. Maestas, August Swanson, Daniel M. Kalb, Andrew P. Shreve, Travis A. Woods, Jaime J. Juárez, Steven W. Graves
Publikováno v:
Analytical Chemistry. 89:9967-9975
Flow cytometry provides highly sensitive multiparameter analysis of cells and particles but has been largely limited to the use of a single focused sample stream. This limits the analytical rate to ∼50K particles/s and the volumetric rate to ∼250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f36d204726ae773ef1df6de50937ae
https://doi.org/10.1021/acs.analchem.7b02319
https://doi.org/10.1021/acs.analchem.7b02319
Autor:
Mei Ding, Bruce S. Edwards
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da50fe597d34e58fba3c8ec6af6f1ff
https://pubmed.ncbi.nlm.nih.gov/30027816
https://pubmed.ncbi.nlm.nih.gov/30027816
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(7)
Classical therapeutic regimens are subject to toxicity, low efficacy, and/or the development of drug resistance. Thus, the discovery of synergistic drug combinations would permit treatment with lower, tolerable dosages of each agent and restored sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1fd570c817b2d9ab9d0dab1f7093d1
https://pubmed.ncbi.nlm.nih.gov/29842834
https://pubmed.ncbi.nlm.nih.gov/29842834
Autor:
Li Luo, T Fabiola Miscioscia, Jake Strouse, Charuta C. Palsuledesai, Susan Young, Cristian Bologa, Harold A. Ames, Ramona Curpan, Orazio Nicolotti, Tudor I. Oprea, Bruce S. Edwards, Angela Wandinger-Ness, Virginia M. Salas, Zhanna Galochkina, Oleg Ursu, Anna Waller, Mark B. Carter, Yuna Guo, Mark K. Haynes, Larry A. Sklar, Zurab Surviladze, Elsa Romero, Yang Wu, Terry D. Foutz
Publikováno v:
ACS chemical biology. 13(6)
Ras and Ras-related small GTPases are key regulators of diverse cellular functions that impact cell growth, survival, motility, morphogenesis, and differentiation. They are important targets for studies of disease mechanisms as well as drug discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b4e73bea64eddf8a45bba74a3d88c7
https://pubmed.ncbi.nlm.nih.gov/29746086
https://pubmed.ncbi.nlm.nih.gov/29746086
Autor:
Dominique Perez, Stephen P. Hunger, Alexandre Chigaev, Michelle L. Hermiston, Cristina Delgado-Martin, Travis A. Woods, Bruce S. Edwards, Ksenia Matlawska-Wasowska, Anna Waller, Nitesh D. Sharma, Stuart S. Winter, Mignon L. Loh, Larry A. Sklar, Christian K. Nickl
Publikováno v:
SLAS discovery : advancing life sciences R & D, vol 23, iss 7
Kinase inhibitors have dramatically increased patient survival in a multitude of cancers, including hematological malignancies. However, kinase inhibitors have not yet been integrated into current clinical trials for patients with T-cell lineage acut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d09a3fbd8cba1c062b5dc9a71ba3c1
https://europepmc.org/articles/PMC6292518/
https://europepmc.org/articles/PMC6292518/
