Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Bruce S. Bochner"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a sialoside-binding receptor expressed by eosinophils and mast cells that exhibits priming status- and cell type-dependent inhibitory activity. On eosinophils that have been primed with IL-
Externí odkaz:
https://doaj.org/article/5786e146a72f4317828ee7f778030fb2
Autor:
Ragha V. Suresh, Collin Dunnam, Dhananjay Vaidya, Robert A. Wood, Bruce S. Bochner, Donald W. MacGlashan Jr., Melanie C. Dispenza
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 16 (2023)
BACKGROUND IgE-mediated anaphylaxis is a potentially fatal systemic allergic reaction for which there are no currently FDA-approved preventative therapies. Bruton’s tyrosine kinase (BTK) is an essential enzyme for IgE-mediated signaling pathways an
Externí odkaz:
https://doaj.org/article/e42a1e5de741462789e1c7a8dbc26244
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-5 (2020)
Abstract Objective Little has been reported regarding the reliability of methods for the purification of human blood eosinophils. We retrospectively reviewed our experience with 350 consecutive eosinophil isolations. Results Between January 2014 and
Externí odkaz:
https://doaj.org/article/80104cf7b88a4b85853faa747e97f637
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a glycan-binding receptor bearing immunoreceptor tyrosine-based inhibitory and switch motifs (ITIM and ITSM, respectively) that is selectively expressed on eosinophils, mast cells, and, to
Externí odkaz:
https://doaj.org/article/dacba8be84b643058268c1a96c1faa4b
Autor:
Simon Gebremeskel, Julia Schanin, Krysta M. Coyle, Melina Butuci, Thuy Luu, Emily C. Brock, Alan Xu, Alan Wong, John Leung, Wouter Korver, Ryan D. Morin, Robert P. Schleimer, Bruce S. Bochner, Bradford A. Youngblood
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as a driver of the hyperinflammatory response seen in COVID-19. However
Externí odkaz:
https://doaj.org/article/6c36a84cb2e642e38ca9f2806e606704
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Despite attempts to halt it, the prevalence of food allergy is increasing, and there is an unmet need for strategies to prevent morbidity and mortality from food-induced allergic reactions. There are no known medications that can prevent anaphylaxis,
Externí odkaz:
https://doaj.org/article/bdfaaa009853471da96b8abf3d64203a
Autor:
Piper A. Robida, Clayton H. Rische, Netali Ben-Baruch Morgenstern, Rethavathi Janarthanam, Yun Cao, Rebecca A. Krier-Burris, Wouter Korver, Alan Xu, Thuy Luu, Julia Schanin, John Leung, Marc E. Rothenberg, Joshua B. Wechsler, Bradford A. Youngblood, Bruce S. Bochner, Jeremy A. O’Sullivan
Publikováno v:
Cells, Vol 11, Iss 7, p 1138 (2022)
Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed. Siglec-6 is
Externí odkaz:
https://doaj.org/article/aa4a409462d94394aa31a086eef4afb4
Autor:
Bradford A. Youngblood, John Leung, Rustom Falahati, Jason Williams, Julia Schanin, Emily C. Brock, Bhupinder Singh, Alan T. Chang, Jeremy A. O’Sullivan, Robert P. Schleimer, Nenad Tomasevic, Christopher R. Bebbington, Bruce S. Bochner
Publikováno v:
Cells, Vol 10, Iss 1, p 19 (2020)
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosi
Externí odkaz:
https://doaj.org/article/3a9df22d546640558f4cd6fc839dc654
Publikováno v:
Frontiers in Medicine, Vol 4 (2017)
The historical focus on protein–protein interactions in biological systems, at the expense of attention given to interactions between other classes of molecules, has overlooked important and clinically relevant processes and points of potential cli
Externí odkaz:
https://doaj.org/article/f40563cbfc534d8c988b2caf5c676472
Autor:
Yadong Wei, Krishan D. Chhiba, Fengrui Zhang, Xujun Ye, Lihui Wang, Li Zhang, Piper A. Robida, Liliana Moreno-Vinasco, Ronald L. Schnaar, Axel Roers, Karin Hartmann, Chang-Min Lee, Delia Demers, Tao Zheng, Bruce S. Bochner, Zhou Zhu
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 1, p 19 (2018)
Sialic acid-binding Ig-like lectin 8 (Siglec-8) is expressed on the surface of human eosinophils, mast cells, and basophils—cells that participate in allergic and other diseases. Ligation of Siglec-8 by specific glycan ligands or antibodies trigger
Externí odkaz:
https://doaj.org/article/0914fd126b25401b9b3e7e0edac429f7