Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Bruce R. Troen"'
Autor:
Tobia Zanotto, Danya Pradeep Kumar, Abbas Tabatabaei, Sharon G. Lynch, Jianghua He, Trent J. Herda, Hannes Devos, Ramkumar Thiyagarajan, Lee Chaves, Kenneth Seldeen, Bruce R. Troen, Jacob J. Sosnoff
Publikováno v:
Pilot and Feasibility Studies, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background Frailty, a syndrome characterized by decreased reserve and resistance to stressors across multiple physiologic systems, is highly prevalent in people living with multiple sclerosis (pwMS), independent of age or disability level. F
Externí odkaz:
https://doaj.org/article/cdad26a553f64b8db2c1ef8fc6e2537c
Autor:
Carl I. Cohen, Saeed Hashem, Kay Thwe Kyaw, Sharon A. Brangman, Suzanne Fields, Bruce R. Troen, Michael Reinhardt
Publikováno v:
Medicina, Vol 60, Iss 3, p 426 (2024)
Background and Objectives: For persons with dementia, the relationships between caregiver burden, physical frailty, race, behavioral and psychological symptoms (BPSD), and other associated variables are poorly understood. Only one prior study examine
Externí odkaz:
https://doaj.org/article/f17a7983289b46c0a9fbe90912aaba9c
Autor:
Nika Rajabian, Izuagie Ikhapoh, Shahryar Shahini, Debanik Choudhury, Ramkumar Thiyagarajan, Aref Shahini, Joseph Kulczyk, Kendall Breed, Shilpashree Saha, Mohamed Alaa Mohamed, Susan B. Udin, Aimee Stablewski, Kenneth Seldeen, Bruce R. Troen, Kirkwood Personius, Stelios T. Andreadis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Aged myoblasts suffer from impaired glycolysis and insulin resistance, but increase methionine catabolism, possibly to meet energetic demands. Here, authors show that inhibiting methionine metabolism via NANOG reprogramming or MAT2A inhibition restor
Externí odkaz:
https://doaj.org/article/20d14dcf72624910a7c1176a420cedc0
Autor:
Kyu Hwan Kwack, Lixia Zhang, Elliot D. Kramer, Ramkumar Thiyagarajan, Natalie A. Lamb, Yukitomo Arao, Jonathan E. Bard, Kenneth L. Seldeen, Bruce R. Troen, Perry J. Blackshear, Scott I. Abrams, Keith L. Kirkwood
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Aging results in enhanced myelopoiesis, which is associated with an increased prevalence of myeloid leukemias and the production of myeloid-derived suppressor cells (MDSCs). Tristetraprolin (TTP) is an RNA binding protein that regulates immune-relate
Externí odkaz:
https://doaj.org/article/427ac34cc1534c908d01b12010e3fcba
Autor:
Peter L. Elkin, Skyler Resendez, Sarah Mullin, Bruce R. Troen, Manoj J. Mammen, Shirley Chang, Gillian Franklin, Wilmon McCray, Steven H. Brown
Publikováno v:
Journal of Clinical and Translational Science, Vol 6 (2022)
Abstract Introduction: COVID-19 is a major health threat around the world causing hundreds of millions of infections and millions of deaths. There is a pressing global need for effective therapies. We hypothesized that leukotriene inhibitors (LTIs),
Externí odkaz:
https://doaj.org/article/16a200ad10ca4227a93abbfcb0f8c99c
Autor:
Jean Wactawski-Wende, Kathleen M. Hovey, Kexin Zhu, Hailey R. Banack, Heather M. Ochs-Balcom, Michael J. LaMonte, William J. Evans, Mahalakshmi Shankaran, Bruce R. Troen
Publikováno v:
J Gerontol A Biol Sci Med Sci
Background The D3-creatine (D3Cr) dilution method provides a direct measure of skeletal muscle. The aim of this study was to compare the association of D3Cr muscle mass with lean body mass (LBM) measured by dual-energy x-ray absorptiometry (DXA) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569c88cd1287eccd07801313ae1cf5d7
https://doi.org/10.1093/gerona/glab020
https://doi.org/10.1093/gerona/glab020
Autor:
Debanik Choudhury, Na Rong, Izuagie Ikhapoh, Nika Rajabian, Georgios Tseropoulos, Yulun Wu, Pihu Mehrotra, Ramkumar Thiyagarajan, Aref Shahini, Kenneth L. Seldeen, Bruce R. Troen, Pedro Lei, Stelios T. Andreadis
Publikováno v:
Cell reports. 41(9)
Mitochondrial dysfunction, a hallmark of aging, has been associated with the onset of aging phenotypes and age-related diseases. Here, we report that impaired mitochondrial function is associated with increased glutamine catabolism in senescent human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05fa712c1900956cdc42584c1f24baa
https://pubmed.ncbi.nlm.nih.gov/36450260
https://pubmed.ncbi.nlm.nih.gov/36450260
Publikováno v:
J Am Geriatr Soc
Objectives Selection bias is a well-known concern in research on older adults. We discuss two common forms of selection bias in aging research: (1) survivor bias and (2) bias due to loss to follow-up. Our objective was to review these two forms of se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c4f0245aaca27b98cd34bb88a7529b
https://doi.org/10.1111/jgs.16022
https://doi.org/10.1111/jgs.16022
Autor:
Mamdouh Khalil, Damian E. Myers, Manhui Pang, Sandra Bermeo, Gustavo Duque, Ahmed Al Saedi, Bruce R. Troen, Christopher Vidal
Publikováno v:
Bone. 122:114-122
Bone and fat cells have an antagonistic relationship. Adipocytes exert a toxic effect on bone cells in vitro through the secretion of fatty acids, which are synthesized by fatty acid synthase (FAS). Inhibition of FAS in vitro rescues osteoblasts from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b354961194767540072a899747353ecc
https://doi.org/10.1016/j.bone.2019.02.017
https://doi.org/10.1016/j.bone.2019.02.017