Zobrazeno 1 - 10
of 1 290
pro vyhledávání: '"Bruce R. Blazar"'
Autor:
Craig P. Collins, Lam T. Khuat, Gail D. Sckisel, Logan V. Vick, Christine M. Minnar, Cordelia Dunai, Catherine T. Le, Brendan D. Curti, Marka Crittenden, Alexander Merleev, Michael Sheng, Nelson J. Chao, Emanual Maverakis, Spencer R. Rosario, Arta M. Monjazeb, Bruce R. Blazar, Dan L. Longo, Robert J. Canter, William J. Murphy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of long-lived memory T c
Externí odkaz:
https://doaj.org/article/1e288536df9248b1a327800dd3a6007e
Autor:
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Cornelius Miething, Uta S. Martens, Khalid Shoumariyeh, Rosa P. Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R. Blazar, Burkhard Becher, Melanie Boerries, Robert Zeiser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Patients with corticosteroid-refractory acute graft-versus-host disease (aGVHD) have a low one-year survival rate. Identification and validation of novel targetable kinases in patients who experience corticosteroid-refractory-aGVHD may help
Externí odkaz:
https://doaj.org/article/cb63dbf7545c4a79898fb5a39c9842f1
Autor:
Alexandra Zanin-Zhorov, Wei Chen, Julien Moretti, Melanie S. Nyuydzefe, Iris Zhorov, Rashmi Munshi, Malavika Ghosh, Cindy Serdjebi, Kelli MacDonald, Bruce R. Blazar, Melissa Palmer, Samuel D. Waksal
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The pathogenesis of hepatic fibrosis is driven by dysregulated metabolism precipitated by chronic inflammation. Rho-associated coiled-coil-containing protein kinases (ROCKs) have been implicated in these processes, however the ability of sel
Externí odkaz:
https://doaj.org/article/1360ef435b4a4bcb8e0d0bb6c03f33cd
Autor:
Marco Calafiore, Ya-Yuan Fu, Paola Vinci, Viktor Arnhold, Winston Y. Chang, Suze A. Jansen, Anastasiya Egorova, Shuichiro Takashima, Jason Kuttiyara, Takahiro Ito, Jonathan Serody, Susumu Nakae, Heth Turnquist, Johan van Es, Hans Clevers, Caroline A. Lindemans, Bruce R. Blazar, Alan M. Hanash
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Intestinal stem cells (ISCs) maintain the epithelial lining of the intestines, but mechanisms regulating ISCs and their niche after damage remain poorly understood. Utilizing radiation injury to model intestinal pathology, we report here tha
Externí odkaz:
https://doaj.org/article/9b625ca7598346a7aef6d804ad1b9d63
Autor:
Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podestà, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Follicular helper T (Tfh) cells have been implicated in controlling rejection after allogeneic kidney transplantation, but the precise subsets, origins, and functions of Tfh cells in this process have not been fully characterized. Here we show that a
Externí odkaz:
https://doaj.org/article/5122775d69f9498d8cea514882fb5871
Autor:
Catherine T. Le, Logan V. Vick, Craig Collins, Cordelia Dunai, Michael K. Sheng, Lam T. Khuat, Isabel Barao, Sean J. Judge, Ethan G. Aguilar, Brendan Curti, Maneesh Dave, Dan L. Longo, Bruce R. Blazar, Robert J. Canter, Arta M. Monjazeb, William J. Murphy
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Bystander activation of memory T cells occurs via cytokine signaling alone in the absence of T cell receptor (TCR) signaling and provides a means of amplifying T cell effector responses in an antigen-nonspecific manner. While the role of Programmed C
Externí odkaz:
https://doaj.org/article/61038b8528944e2fac44a9057e6d02fd
Autor:
Brent R. Logan, Denggang Fu, Alan Howard, Mingwei Fei, Jianqun Kou, Morgan R. Little, Djamilatou Adom, Fathima A. Mohamed, Bruce R. Blazar, Philip R. Gafken, Sophie Paczesny
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 15 (2023)
BACKGROUND Chronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic hematopoietic cell transplantation (HCT). More accurate information regarding the risk of developing cGVHD is required. Bone marrow (BM) grafts contribute to
Externí odkaz:
https://doaj.org/article/a11b421307fe47d08b958d9f48b3ac8c
Autor:
Hemn Mohammadpour, Takemasa Tsuji, Cameron R. MacDonald, Joseph L. Sarow, Hanna Rosenheck, Saeed Daneshmandi, Jee Eun Choi, Jingxin Qiu, Junko Matsuzaki, Agnieszka K. Witkiewicz, Kristopher Attwood, Bruce R. Blazar, Kunle Odunsi, Elizabeth A. Repasky, Philip L. McCarthy
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112250- (2023)
Summary: Abundant donor cytotoxic T cells that attack normal host organs remain a major problem for patients receiving allogeneic hematopoietic cell transplantation (allo-HCT). Despite an increase in our knowledge of the pathobiology of acute graft v
Externí odkaz:
https://doaj.org/article/f1e3b8cf52994b1c9c4108441a3ac6b7
Autor:
Wenji Piao, Lushen Li, Vikas Saxena, Jegan Iyyathurai, Ram Lakhan, Yigang Zhang, Isadora Tadeval Lape, Christina Paluskievicz, Keli L. Hippen, Young Lee, Emma Silverman, Marina W. Shirkey, Leonardo V. Riella, Bruce R. Blazar, Jonathan S. Bromberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The Programmed death-1 (PD-1) and its ligand PD-L1 are critical checkpoints in the regulation of immune responses. Here the authors implicate PD-L1 signalling at lymphatic endothelium in the regulation of transendothelial migration of T cells.
Externí odkaz:
https://doaj.org/article/95f1ec3c1b3240e0a0c30c1a91d6a299
Autor:
Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung-On Yau, Rupkatha Mukhopadhyay, Benjamin Dickins, Heidi Altmann, Michael Kramer, Hanna A. Knaus, Bruce R. Blazar, Vedran Radojcic, Joshua F. Zeidner, Andrea Arruda, Bofei Wang, Hussein A. Abbas, Mark D. Minden, Sarah K. Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
Background Immune exhaustion and senescence are dominant dysfunctional states of effector T cells and major hurdles for the success of cancer immunotherapy. In the current study, we characterized how acute myeloid leukemia (AML) promotes the generati
Externí odkaz:
https://doaj.org/article/9b9ef0d762ff4c06a07a3be5dd99fa73