Výsledky vyhledávání - "Bruce R, Pawel"

Akademický článek

Fibroblasts and macrophages cooperate to create a pro-tumorigenic and immune resistant environment via activation of TGF-β/IL-6 pathway in neuroblastoma

Autor: Kevin Louault, Tania Porras, Meng-Hua Lee, Sakunthala Muthugounder, Rebekah J. Kennedy, Laurence Blavier, Emily Sarte, G. Esteban Fernandez, Fusheng Yang, Bruce R. Pawel, Hiroyuki Shimada, Shahab Asgharzadeh, Yves A. DeClerck

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

Tumor-associated macrophages (TAM) and cancer-associated fibroblasts (CAF) and their precursor mesenchymal stromal cells (MSC) are often detected together in tumors, but how they cooperate is not well understood. Here, we show that TAM and CAF are th

Externí odkaz: https://doaj.org/article/e3a9711c53f144c9ad2f0492fa1ecbf7

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Supplementary Figure 5 from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Autor: Craig B. Thompson, Joshua D. Rabinowitz, M. Celeste Simon, Zhandong Liu, Guoliang Qing, Justin R. Cross, Tullia Lindsten, Chao Lu, Lydia W.S. Finley, Ji Zhang, Bruce R. Pawel, Ying-Wooi Wan, Sriram Venneti, Jing Fan, Jiangbin Ye

Kelly cells stably expressing non-targeting shRNA (shNT) or SHMT2 shRNA (shSHMT2) were exposed to normoxia (Nor) or 0.5% O2 (Hyp) for 48 hours incubated with glucose concentrations indicated, % cell viability was determined using Trypan Blue staining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdfc866871bc60a3f5b6289091b2a59
https://doi.org/10.1158/2159-8290.22530237

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Supplementary Figure 1B from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

The correlation of SHMT2 and PHGDH expression in the samples from patients who died from the disease (top panel, pPHGDHvsSHMT1=0.092, pPHGDHvsSHMT2=7.3Ã—10-5) and the correlation found in the samples from patients where the tumor regressed or matu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c5d043009b0cb12dbcc00737f1166e
https://doi.org/10.1158/2159-8290.22530249.v1

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Supplementary Figure 2 from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

The hypoxic induction of SHMT2 depends on HIF-1alpha. SK-N-BE(2) cells stably expressing non-targeting shRNA or a shRNA against HIF-1alpha were exposed to normoxia (Nor) or 0.5% O2 (Hyp) for 8 hours. mRNA levels were measured using Q-PCR and normaliz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e82ae8a9105aedc472c8b2ba1f2848
https://doi.org/10.1158/2159-8290.22530246

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Data from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

The de novo synthesis of the nonessential amino acid serine is often upregulated in cancer. In this study, we demonstrate that the serine catabolic enzyme, mitochondrial serine hydroxymethyltransferase (SHMT2), is induced when MYC-transformed cells a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8266d0ac430f3f818846ba00f495e0
https://doi.org/10.1158/2159-8290.c.6546135

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Supplementary Figure 4 from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(A) Kelly cells stably expressing non-targeting shRNA (shNT) or SHMT2 shRNA (shSHMT2) were exposed to normoxia (Nor) or 0.5% O2 (Hyp) for 24 hours. Total cellular DNA were extracted and relative mitochondria/nuclear DNA ratio were measured using Q-PC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc6fe4b90b9b0e8e5559d58658ec75e
https://doi.org/10.1158/2159-8290.22530240

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Supplementary Figure 3 from Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

(A) Immunoblots of N-Myc and c-Myc in the six cell lines. (B, C) H293T and HT1080 cells were exposed to normoxia (Nor) or 0.5% O2 (Hyp) for 6 or 16 hours, (D) H1299 cells were exposed to normoxia (Nor) or 0.5% O2 (Hyp) for 16 hours. mRNA levels were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298c0802b76d9a19f31d1031b48d44fe
https://doi.org/10.1158/2159-8290.22530243

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Intraoperative Diagnosis for Pediatric Brain Tumors

Autor: Jennifer A Cotter, Linda J Szymanski, Bruce R Pawel, Alexander R Judkins

Publikováno v: Pediatric and Developmental Pathology. 25:10-22

Central nervous system (CNS) tumors are now the most common type of solid tumor in individuals aged 0–19 years, with an incidence rate in the United States around 5 per 100,000, accounting for about 1 out of 4 childhood cancers. Pediatric pathologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80314f8182fb9c00cfe1d3437676e330
https://doi.org/10.1177/10935266211018932

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