Výsledky vyhledávání - "Bruce P. Shutts"

Amino Diol Based Asymmetric Syntheses of a Fused Benzazepine as a Selective D1 Dopamine Receptor

Autor: and George M. Love, Martin Steinman, Yee-Shing Wong, Bruce P. Shutts, Doris P. Schumacher, W. Tormos, Guang-Zhong Wu

Publikováno v: Organic Process Research & Development. 1:359-364

A six-step practical synthesis of (6aS,13bR)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphtho[2,1-b]azepin-12-ol, a selective D1 dopamine receptor, is developed starting from (1S,2S)-phenyl-2-amino-1,3-propanediol. An acid-promoted ster

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::198a41ad712c9af0e31e2edd02d8083a
https://doi.org/10.1021/op970105v

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Antitumour imidazotetrazines. Part 33. New syntheses of the antitumour drug temozolomide using ‘masked’ methyl isocyanates

Autor: Malcolm F. G. Stevens, Bruce P. Shutts, William Thomson, Yongfeng Wang

Publikováno v: J. Chem. Soc., Perkin Trans. 1. :2783-2787

Ethyl 8-carbamoyl-4-oxo-3,4-dihydroimidazo[5,1-d]-1,2,3,5-tetrazin-3-ylacetate 6a can be prepared by treating 5-diazoimidazole-4-carboxamide 3 with ethyl isocyanatoacetate or by diazotisation of N-(5-amino-4-carbamoylimidazol-1-ylcarbonyl)glycine eth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6595823d7bfd508cf00d4507d8c9706
https://doi.org/10.1039/p19950002783

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ChemInform Abstract: Amino Diol Based Asymmetric Syntheses of a Fused Benzazepine as a Selective D1 Dopamine Receptor

Autor: Martin Steinman, G. M. Love, YeeShing Wong, W. Tormos, Bruce P. Shutts, Doris P. Schumacher, Guangzhong Wu

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::907a1ca4707644e54e4284029241aff7
https://doi.org/10.1002/chin.199807180

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Antitumor Imidazotetrazines. 35. New Synthetic Routes to the Antitumor Drug Temozolomide

Autor: Donald Hou, Doris P. Schumacher, Janet L. Mas, William Thomson, Shen-Chun Kuo, Malcolm F. G. Stevens, Donald J. Dibenedetto, Zheng-Yun J. Zhan, Zhe-xing Ding, William Leong, Yongfeng Wang, Tze-Ming Chan, Max Kugelman, Bruce P. Shutts, Lyman H. Smith, Dinesh Gala

Publikováno v: The Journal of organic chemistry. 62(21)

Three new pathways to the antitumor drug temozolomide (4) have been explored via intermediates 3, 6, and 7. The key intermediate 5-amino-1-(N-methylcarbamoyl)imidazole-4-carboxamide (6) has been successfully converted to 4 in 45% yield by employing s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1978e92a3110f599f6fa41a90f7dedf5
https://pubmed.ncbi.nlm.nih.gov/11671842

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