Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Bruce P, Hamilton"'
Autor:
Wendy A. Alcaraz, Zheng Liu, Phoebe Valdes, Edward Chen, Alan G. Valdovino Gonzalez, Shelby Wade, Cinny Wong, Eunnie Kim, Hsiang-Hua M. Chen, Alison Ponn, Dorothy Concepcion, Bruce A. Hamilton
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 11, Pp 4241-4247 (2020)
Zfp423 encodes a transcriptional regulatory protein that interacts with canonical signaling and lineage pathways. Mutations in mouse Zfp423 or its human ortholog ZNF423 are associated with a range of developmental abnormalities reminiscent of ciliopa
Externí odkaz:
https://doaj.org/article/6e5bb2bb3299407ab39f5841ebf65330
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1009017 (2020)
Interpreting rare variants remains a challenge in personal genomics, especially for disorders with several causal genes and for genes that cause multiple disorders. ZNF423 encodes a transcriptional regulatory protein that intersects several developme
Externí odkaz:
https://doaj.org/article/919cea7be434416790baa4390e34fcb3
Autor:
Bruce A Hamilton
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006476 (2016)
Externí odkaz:
https://doaj.org/article/73fb9fe1aa0c484e9215263ebeeb9ef7
Autor:
Chen-Jei Hong, Bruce A Hamilton
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006357 (2016)
Zfp423 encodes a 30-zinc finger transcription factor that intersects several canonical signaling pathways. Zfp423 mutations result in ciliopathy-related phenotypes, including agenesis of the cerebellar vermis in mice and Joubert syndrome (JBTS19) and
Externí odkaz:
https://doaj.org/article/d5143041eff744bcb349bf0465a2f6b0
Autor:
Shuxiao Zhang, Kevin D Ross, Glen A Seidner, Michael R Gorman, Tiffany H Poon, Xiaobo Wang, Elizabeth M Keithley, Patricia N Lee, Mark Q Martindale, William J Joiner, Bruce A Hamilton
Publikováno v:
PLoS Genetics, Vol 11, Iss 7, p e1005344 (2015)
Many protein-coding genes identified by genome sequencing remain without functional annotation or biological context. Here we define a novel protein-coding gene, Nmf9, based on a forward genetic screen for neurological function. ENU-induced and genom
Externí odkaz:
https://doaj.org/article/6c6d31be1630485ab0f0fc1d9298e7cd
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005123 (2015)
Endogenous retroviruses and retrotransposons contribute functional genetic variation in animal genomes. In mice, Intracisternal A Particles (IAPs) are a frequent source of both new mutations and polymorphism across laboratory strains. Intronic IAPs c
Externí odkaz:
https://doaj.org/article/2924f08e56594c16b79d139586c4abf0
Autor:
Bruce A Hamilton
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003331 (2013)
Externí odkaz:
https://doaj.org/article/c79148ad68e14e47b42ae7559fd45f05
Autor:
Young-Wook Cho, Chen-Jei Hong, Aiju Hou, Peter M Gent, Kuixing Zhang, Kyoung-Jae Won, Bruce A Hamilton
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66514 (2013)
Zfp423 is a 30 zinc finger transcription factor that forms regulatory complexes with EBF family members and factors targeted by canonical signaling pathways. Zfp423 mutations produce a range of developmental abnormalities in mice and humans related t
Externí odkaz:
https://doaj.org/article/83aae13f6de84a0b972c630be41178da
Autor:
Bruce A Hamilton, Benjamin D Yu
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002644 (2012)
Modifier genes are an integral part of the genetic landscape in both humans and experimental organisms, but have been less well explored in mammals than other systems. A growing number of modifier genes in mouse models of disease nonetheless illustra
Externí odkaz:
https://doaj.org/article/19036e197e8e4fab91836d6721f108c0
Publikováno v:
PLoS Genetics, Vol 5, Iss 5, p e1000484 (2009)
Cellular gene expression machinery has coevolved with molecular parasites, such as viruses and transposons, which rely on host cells for their expression and reproduction. We previously reported that a wild-derived allele of mouse Nxf1 (Tap), a key c
Externí odkaz:
https://doaj.org/article/3a8799054f6c4a9c9c2e378aaecfac7d