Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Bruce P, Damiano"'
Autor:
Hua Rong Lu, Bruce P. Damiano, Mohamed Kreir, Jutta Rohrbacher, Henk van der Linde, Tamerlan Saidov, Ard Teisman, David J. Gallacher
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1355 (2023)
Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported. We evaluated loperamide in in vitro and in vivo cardiac
Externí odkaz:
https://doaj.org/article/c7cdd87a46974314ad2466c9c4b2542c
Autor:
Andrew L. Darrow, Matthew W. Olson, Hong Xin, Sharon L. Burke, Charles Smith, Celine Schalk-Hihi, Robyn Williams, Shariff S. Bayoumy, Ingrid C. Deckman, Matthew J. Todd, Bruce P. Damiano, Margery A. Connelly
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 374-382 (2011)
Endothelial lipase (EL) is a phospholipase A1 (PLA1) enzyme that hydrolyzes phospholipids at the sn-1 position to produce lysophospholipids and free fatty acids. Measurement of the PLA1 activity of EL is usually accomplished by the use of substrates
Externí odkaz:
https://doaj.org/article/629a71b67d5a4d33bf52e845fd601090
Autor:
Adam P. Hill, Zhen Song, Haibo Ni, Norman Stockbridge, David G. Strauss, Jamie I. Vandenberg, Todd Wisialowski, Mikiko Nakamura, Takashi Yoshinaga, Godfrey L. Smith, Jill Steidl‐Nichols, Mark Holbrook, Stefano Severi, Pierre Morissette, Derek J. Leishman, Colleen E. Clancy, Gary R. Mirams, Andrea Greiter-Wilke, Andrew G. Edwards, Xiaomei Han, Zhihua Li, Flora Musuamba Tshinanu, Stefano Morotti, Stephane Nave, Aaron Fullerton, Bradley J. Ridder, Zhilin Qu, Michelangelo Paci, Alfonso Bueno-Orovio, Janell E. Chen, Thomas Singer, Peter R. Kowey, Liudmila Polonchuk, Eric A. Sobie, Blanca Rodriguez, Randall L. Rasmusson, Elisa Passini, Eleonora Grandi, Ken Wang, Michael Liu, Bruce P. Damiano, Xin Zhou
Publikováno v:
Clinical pharmacology and therapeutics, vol 107, iss 1
Clinical Pharmacology and Therapeutics
Clinical Pharmacology and Therapeutics
This white paper presents principles for validating proarrhythmia risk prediction models for regulatory use as discussed at the In Silico Breakout Session of a Cardiac Safety Research Consortium/Health and Environmental Sciences Institute/US Food and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2ff4e1c2fbbbeb607662c3df93ed0e
https://doi.org/10.1002/cpt.1647
https://doi.org/10.1002/cpt.1647
Autor:
Henk van der Linde, Yves Somers, Bruce P. Damiano, Bruno Van Deuren, David J. Gallacher, Mariusz Lubomirski, Ard Teisman
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 72:72-84
Introduction Preclinical proarrhythmic risk assessment of drug candidates is focused predominantly on arrhythmias arising from repolarization abnormalities. However, drug-induced cardiac conduction slowing is associated with significant risk of life-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb5b05c1c285fdb625c062c03cd78c9
https://doi.org/10.1016/j.vascn.2014.10.006
https://doi.org/10.1016/j.vascn.2014.10.006
Autor:
Ard Teisman, Ivan Kopljar, Hua Rong Lu, Bruce P. Damiano, An De Bondt, Nick Goeminne, David J. Gallacher, Petra Vinken, Ilse Van den Wyngaert
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 88:239-240
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ba5a4eb19a001ee3813ec0f87db4550
https://doi.org/10.1016/j.vascn.2017.09.233
https://doi.org/10.1016/j.vascn.2017.09.233
Autor:
Sharon L. Burke, Andrew L. Darrow, Robyn Williams, Margery A. Connelly, Charles Smith, Bruce P. Damiano, Celine Schalk-Hihi, Matthew J. Todd, Matthew Wayne Olson, Hong Xin, Ingrid C. Deckman, Shariff Bayoumy
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 374-382 (2011)
Endothelial lipase (EL) is a phospholipase A1 (PLA1) enzyme that hydrolyzes phospholipids at the sn-1 position to produce lysophospholipids and free fatty acids. Measurement of the PLA1 activity of EL is usually accomplished by the use of substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a2501c49343c43115f72e19077234b
https://doi.org/10.1194/jlr.d007971
https://doi.org/10.1194/jlr.d007971
Autor:
Patricia Andrade-Gordon, Barbara J. Haertlein, Bruce P. Damiano, Bruce E. Maryanoff, Michael J. Costanzo, Edward C. Giardino, Lawrence de Garavilla
Publikováno v:
Blood Coagulation & Fibrinolysis. 21:128-134
Whereas heparin functions as an antithrombotic agent by promoting antithrombin III-based inhibition of thrombin and factor Xa, there is less appreciation for the combination behavior with small-molecule, direct inhibitors of these proteases. We condu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b489f1dabf8ac3c04bf110876330837f
https://doi.org/10.1097/mbc.0b013e3283358100
https://doi.org/10.1097/mbc.0b013e3283358100
Autor:
Keith T. Demarest, Wai-man Cheung, Philip J. Rybczynski, Lisa Minor, Bruce P. Damiano, Pamela G. Wines, Tom Jay Parry, Min Xiang, Lawrence de Garavilla, Patricia Andrade-Gordon, Bruce E. Maryanoff, Joseph W. Gunnet
Publikováno v:
European Journal of Pharmacology. 590:333-342
The dysregulation of arginine vasopressin (AVP) release and activation of vasopressin V 1A and V 2 receptors may play a role in disease. The in vitro and in vivo pharmacology of RWJ-676070, a potent, balanced antagonist of both the V 1A and V 2 recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c308a8d2b5b2c828bbda2d9ddc5decec
https://doi.org/10.1016/j.ejphar.2008.06.010
https://doi.org/10.1016/j.ejphar.2008.06.010
Autor:
Tom Jay Parry, Bruce P. Damiano, Hong Ye, Barbara J. Haertlein, Cailin Chen, Bruce E. Maryanoff, Han-Cheng Zhang
Publikováno v:
ChemMedChem. 3:732-736
Whereas the activation and aggregation of blood platelets are crucial to normal hemostasis, this ensemble is also a key factor in serious cardiovascular disorders, such as myocardial infarction, unstable angina, transient ischemic attack, stroke, per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0e70f1988416345af4d6f8f152e656
https://doi.org/10.1002/cmdc.200700310
https://doi.org/10.1002/cmdc.200700310
Autor:
Shyamali Ghosh, William A. Kinney, Harold R. Almond, Bruce E. Maryanoff, Barbara J. Haertlein, Bruce P. Damiano, Edward C. Lawson, Lisa Minor, Jenson Qi, Tom Jay Parry, Charles E. Smith, Jian Li, Yuanping Wang, Diane K. Luci
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6489-6492
Various 4-phenylpiperidine-benzoxazin-3-ones were synthesized and biologically evaluated as urotensin-II (U-II) receptor antagonists. Compound 12i was identified from in vitro evaluation as a low nanomolar antagonist against both rat and human U-II r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421e43e92f218716c7dcf71ff9abff18
https://doi.org/10.1016/j.bmcl.2007.09.092
https://doi.org/10.1016/j.bmcl.2007.09.092