Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Bruce P, Bean"'
Autor:
Jian Huang, Xiao Fan, Xueqin Jin, Sooyeon Jo, Hanxiong Bear Zhang, Akie Fujita, Bruce P. Bean, Nieng Yan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Cannabidiol (CBD), a major non-psychoactive phytocannabinoid in cannabis, is an effective treatment for some forms of epilepsy and pain. At high concentrations, CBD interacts with a huge variety of proteins, but which targets are most releva
Externí odkaz:
https://doaj.org/article/9c8c96144a18431cb24c94a3e10004a1
Autor:
Han-Xiong Bear Zhang, Laurel Heckman, Zachary Niday, Sooyeon Jo, Akie Fujita, Jaehoon Shim, Roshan Pandey, Hoor Al Jandal, Selwyn Jayakar, Lee B Barrett, Jennifer Smith, Clifford J Woolf, Bruce P Bean
Publikováno v:
eLife, Vol 11 (2022)
Cannabidiol (CBD), a chemical found in the Cannabis sativa plant, is a clinically effective antiepileptic drug whose mechanism of action is unknown. Using a fluorescence-based thallium flux assay, we performed a large-scale screen and found enhanceme
Externí odkaz:
https://doaj.org/article/e58eafd704e84f2b9bdbc4303277ac23
Autor:
Tao Deng, Vukasin M. Jovanovic, Carlos A. Tristan, Claire Weber, Pei-Hsuan Chu, Jason Inman, Seungmi Ryu, Yogita Jethmalani, Juliana Ferreira de Sousa, Pinar Ormanoglu, Prisca Twumasi, Chaitali Sen, Jaehoon Shim, Selwyn Jayakar, Han-Xiong Bear Zhang, Sooyeon Jo, Weifeng Yu, Ty C. Voss, Anton Simeonov, Bruce P. Bean, Clifford J. Woolf, Ilyas Singeç
Publikováno v:
Stem Cell Reports. 18:1030-1047
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee5882b75a557d5d1fb78b4340bdcb9f
https://doi.org/10.1016/j.stemcr.2023.03.006
https://doi.org/10.1016/j.stemcr.2023.03.006
Publikováno v:
Molecular Pharmacology. 103:221-229
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aace8aa3e6d24a6bff5130a05894536c
https://doi.org/10.1124/molpharm.122.000593
https://doi.org/10.1124/molpharm.122.000593
Autor:
Seungkyu Lee, Sooyeon Jo, Sébastien Talbot, Han-Xiong Bear Zhang, Masakazu Kotoda, Nick A Andrews, Michelino Puopolo, Pin W Liu, Thomas Jacquemont, Maud Pascal, Laurel M Heckman, Aakanksha Jain, Jinbo Lee, Clifford J Woolf, Bruce P Bean
Publikováno v:
eLife, Vol 8 (2019)
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of lo
Externí odkaz:
https://doaj.org/article/de64bb25275445b0a3e4407fe3462af5
Autor:
Xuan Huang, Seungkyu Lee, Riki Kawaguchi, Ole Wiskow, Sulagna Ghosh, Devlin Frost, Laura Perrault, Roshan Pandey, Kuchuan Chen, Joseph R. Klim, Bruno Boivin, Crystal Hermawan, Kenneth J. Livak, Dan Geschwind, Brian J. Wainger, Kevin Eggan, Bruce P. Bean, Clifford J Woolf
The Kv8.1 potassium ion channel encoded by the KCNV1 gene is a “silent” subunit whose biological function is unknown. In ALS patient-derived motor neurons carrying SOD1(A4V) and C9orf72 mutations, its expression is highly reduced, yielding increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff65e2977922e80a2523734bae62801e
https://doi.org/10.1101/2023.05.07.539778
https://doi.org/10.1101/2023.05.07.539778
Autor:
Han-Xiong Bear Zhang, Bruce P. Bean
Publikováno v:
The Journal of Neuroscience. 41:6371-6387
The nonpsychoactive phytocannabinoid cannabidiol (CBD) has been shown to have analgesic effects in animal studies but little is known about its mechanism of action. We examined the effects of CBD on intrinsic excitability of primary pain-sensing neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3b7521d8aa9e6501ca36818f7c990f7
https://doi.org/10.1523/jneurosci.3216-20.2021
https://doi.org/10.1523/jneurosci.3216-20.2021
Autor:
Brian J. Wainger, Evangelos Kiskinis, Cassidy Mellin, Ole Wiskow, Steve S.W. Han, Jackson Sandoe, Numa P. Perez, Luis A. Williams, Seungkyu Lee, Gabriella Boulting, James D. Berry, Robert H. Brown Jr., Merit E. Cudkowicz, Bruce P. Bean, Kevin Eggan, Clifford J. Woolf
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 1-11 (2014)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor nervous system. We show using multielectrode array and patch-clamp recordings that hyperexcitability detected by clinical neurophysiological studies of ALS patients
Externí odkaz:
https://doaj.org/article/112c904730ec41668ec020f0d2182e62
Autor:
Zachary Niday, Bruce P. Bean
Publikováno v:
J Neurosci
BK calcium-activated potassium channels have complex kinetics because they are activated by both voltage and cytoplasmic calcium. The timing of BK activation and deactivation during action potentials determines their functional role in regulating fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e190a15e491b05a9351bacd3d6f94334
https://doi.org/10.1523/jneurosci.0192-20.2021
https://doi.org/10.1523/jneurosci.0192-20.2021