Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Bruce N. Cohen"'
Autor:
Kallol Bera, Aron Kamajaya, Amol V. Shivange, Anand K. Muthusamy, Aaron L. Nichols, Philip M. Borden, Stephen Grant, Janice Jeon, Elaine Lin, Ishak Bishara, Theodore M. Chin, Bruce N. Cohen, Charlene H. Kim, Elizabeth K. Unger, Lin Tian, Jonathan S. Marvin, Loren L. Looger, Henry A. Lester
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The target for the “rapid” (100-fold selectivity over other ligands tested, including R-ketamine. We targeted each of the sensors to either the plasma membrane (PM) or the endoplasmic reticulum (ER). Measurements on these biosensors expressed in
Externí odkaz:
https://doaj.org/article/4397d649b8754ebaa97c121f59eaa73b
Autor:
Teagan R. Wall, Brandon J. Henderson, George Voren, Charles R. Wageman, Purnima Deshpande, Bruce N. Cohen, Sharon R. Grady, Michael J. Marks, Daniel Yohannes, Paul J. Kenny, Merouane Bencherif, Henry A. Lester
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, usin
Externí odkaz:
https://doaj.org/article/fe16dc1017fe4cafa3021cac90dfb168
Autor:
Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/098460172c5e405ebfd89ac4744a4398
Autor:
Aaron L. Nichols, Zack Blumenfeld, Laura Luebbert, Hailey J. Knox, Anand K. Muthusamy, Jonathan S. Marvin, Charlene H. Kim, Stephen N. Grant, David P. Walton, Bruce N. Cohen, Rebekkah Hammar, Loren L. Looger, Per Artursson, Dennis A. Dougherty, Henry A. Lester
Publikováno v:
Journal of Neuroscience
bioRxiv
bioRxiv
Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depressive disorder (MDD). The therapeutic mechanisms that take place before, during, or after SSRIs bind the serotonin transporter (
Autor:
Anand K. Muthusamy, Charlene H. Kim, Scott C. Virgil, Hailey J. Knox, Jonathan S. Marvin, Aaron L. Nichols, Bruce N. Cohen, Dennis A. Dougherty, Loren L. Looger, Henry A. Lester
Publikováno v:
Journal of the American Chemical Society, vol 144, iss 19
We report a reagentless, intensity-based S-methadone fluorescent sensor, iS-methadoneSnFR, consisting of a circularly permuted GFP inserted within the sequence of a mutated bacterial periplasmic binding protein (PBP). We evolved a previously reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53972a94019485a4a65506408d036e07
https://resolver.caltech.edu/CaltechAUTHORS:20220228-619163000
https://resolver.caltech.edu/CaltechAUTHORS:20220228-619163000
Autor:
Weston A Nichols, Brandon J Henderson, Christopher B Marotta, Caroline Y Yu, Chris Richards, Dennis A Dougherty, Henry A Lester, Bruce N Cohen
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158032 (2016)
A number of mutations in α4β2-containing (α4β2*) nicotinic acetylcholine (ACh) receptors (nAChRs) are linked to autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), including one in the β2 subunit called β2V287L. Two α4β2* subtypes wi
Externí odkaz:
https://doaj.org/article/f0f4f3c60e354e3f99af307bbfe38ec4
Autor:
Laura Luebbert, Chengcheng Fan, Zack Blumenfeld, Aaron L Nichols, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester
Publikováno v:
eLife, Vol 11 (2022)
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cell
Autor:
Laura Luebbert, Chengcheng Fan, Zack Blumenfeld, Aaron L Nichols, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ba6d7547914bb271a0936a614e02ac3
https://doi.org/10.7554/elife.74648.sa2
https://doi.org/10.7554/elife.74648.sa2
Autor:
Jonathan S. Marvin, Amol V. Shivange, Hailey J. Knox, Loren L. Looger, Henry A. Lester, Charlene H. Kim, Annet E. M. Blom, C. Fan, Timothy Gallagher, Laura Luebbert, Philip M. Borden, Bruce N. Cohen, Aaron L. Nichols, Hugo Rego Campello, Dennis A. Dougherty, Jonathan H. Wang, Zack Blumenfeld, Douglas C. Rees, Anand K. Muthusamy
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10a55da369175a588f45fdc48dd3e8e5
https://doi.org/10.1101/2021.10.04.463082
https://doi.org/10.1101/2021.10.04.463082
Autor:
Philip M. Borden, Kallol Bera, Huan Bao, Bruce N. Cohen, Edwin R. Chapman, Ishak Bishara, Anand K. Muthusamy, Aaron L. Nichols, Jonathan S. Marvin, Amol V. Shivange, Loren L. Looger, Dennis A. Dougherty, Matthew J. Mulcahy, Charlene Kim, Janice Jeon, Saidhbhe L. O'Riordan, Henry A. Lester
Publikováno v:
The Journal of General Physiology
Nicotine dependence is thought to arise in part because nicotine permeates into the endoplasmic reticulum (ER), where it binds to nicotinic receptors (nAChRs) and begins an “inside-out” pathway that leads to up-regulation of nAChRs on the plasma