Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Bruce Mccullough"'
Publikováno v:
Toxicologic Pathology. 32:49-58
Digital microscopy, a comprehensive integration of digital imaging and light microscopy, can assist the pathologist to observe, acquire, record, share, analyze, and manage pathology image data. To lead the activity for establishing new generation dig
Autor:
Jay I. Goodman, Richard D. Storer, Peter Kasper, Douglas A. Keller, Abigail Jacobs, Ronald J. Gerson, Gerald G. Long, John E. French, Tohru Inoue, Amy L. Lavin, James S. MacDonald, Bruce McCullough, Frank D. Sistare, Jan Willem van der Laan
Publikováno v:
Toxicological Sciences. 77:188-194
The Alternatives to Carcinogenicity Testing Committee of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) conducted a large-scale, multinational collaborative research program to evaluate several gen
Autor:
Ray W. Tennant, Ray E. Stoll, Joel F. Mahler, Judson W. Spalding, William C. Eastin, Robert L. Binder, Dan G. Branstetter, Bruce Mccullough, John H. Mennear, John R. Bucher
Publikováno v:
Toxicologic Pathology. 29:60-80
In a Government/Industry/Academic partnership to evaluate alternative approaches to carcinogenicity testing, 21 pharmaceutical agents representing a variety of chemical and pharmacological classes and possessing known human and or rodent carcinogenic
Autor:
Harry Olson, Raymond W. Tennant, Leslie Recio, C. Bruce Mccullough, Donna Gulezian, Denise Robinson, David Jacobson-Kram, Jerrold M. Ward, David A. Neumann, Richard D. Storer
Publikováno v:
Toxicologic Pathology. 28:482-499
Advances in genetic engineering have created opportunities for improved understanding of the molecular basis of carcinogenesis. Through selective introduction, activation, and inactivation of specific genes, investigators can produce mice of unique g
Autor:
Bruce Mccullough, Oral A. Evanson, Douglas J. Weiss, Michael L. Mirsky, David McClenahan, Jose Fagliari
Publikováno v:
Toxicologic Pathology. 28:310-316
Platelet glycoprotein IIb/IIIa (GPIIb/IIIa) receptor antagonists have been highly effective inhibitors of platelet aggregation in preclinical studies and in clinical trials. However, decreased platelet counts have been documented in preclinical studi
Autor:
Marion G. Valerio, Michael V. Pino, Michael L. Mirsky, Pritam S. Sahota, J.D. Frantz, Bruce Mccullough, Glen K. Miller
Publikováno v:
Toxicologic Pathology. 25:335-338
Autor:
Carol Noory, B.N. Srinivasan, Assad Noory, Jerome P. Skelly, Helen Naviasky, Don Fortman, Bruce McCullough, Richard L. Everett, Vinod P. Shah, Sanford Clarke
Publikováno v:
International Journal of Pharmaceutics. 125:99-106
An in vitro procedure for the evaluation of sparingly water-soluble drug products has been developed and tested. The data on several sparingly water-soluble drug products, such as danazol capsules, megestrol acetate tablets, prazosin HCl capsules, an
Publikováno v:
Journal of pharmacological and toxicological methods. 54(3)
Introduction One of the biomarkers for assessing the risk of a cardiac adverse event is drug-induced prolongation of the QT interval. A model is needed for evaluating the potential liability of test compounds on QT interval in vitro. Since QT interva
Autor:
James, MacDonald, John E, French, Ronald J, Gerson, Jay, Goodman, Tohru, Inoue, Abigail, Jacobs, Peter, Kasper, Douglas, Keller, Amy, Lavin, Gerald, Long, Bruce, McCullough, Frank D, Sistare, Richard, Storer, Jan Willem, van der Laan
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 77(2)
The Alternatives to Carcinogenicity Testing Committee of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) conducted a large-scale, multinational collaborative research program to evaluate several gen
Autor:
Bruce Mccullough, Keith A. Soper, Mamoru Mutai, Masaya Takoaka, Toshimi Usui, Carl L. Alden, Shigeru Hisada
Publikováno v:
Toxicologic pathology.
This article presents data from short-term carcinogenicity studies of compounds tested in the CB6F1-rasH2 transgenic mouse as part of the International Life Sciences Institutes' (ILSI) Health and Environmental Sciences' (HESI) Alternative to Carcinog