Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Bruce M. Raaka"'
Publikováno v:
Frontiers in Endocrinology, Vol 3 (2012)
Taltirelin (TAL) is a thyrotropin-releasing hormone (TRH) analog that is approved for use in humans in Japan. In this study, we characterized TAL binding to and signaling by the human TRH receptor (TRH-R) in a model cell system. We found that TAL exh
Externí odkaz:
https://doaj.org/article/3bc5a9102cde479c8a94d4dab09eaa6d
Autor:
Mawadda Alnaeeli, Tatyana Chanturiya, Constance Tom Noguchi, Ruifeng Teng, Bruce M. Raaka, Oksana Gavrilova
Publikováno v:
Diabetes
Obesity-induced white adipose tissue (WAT) inflammation and insulin resistance are associated with macrophage (Mф) infiltration and phenotypic shift from “anti-inflammatory” M2-like to predominantly “proinflammatory” M1-like cells. Erythropo
Publikováno v:
Neuropsychopharmacology. 38:950-956
Thyrotropin-releasing hormone receptor type 2 (TRH-R2), not TRH-R1, has been proposed to mediate the CNS effects of TRH and its more effective analog taltirelin (TAL). Consistent with this idea, TAL exhibited higher binding affinity and signaling pot
Autor:
Bruce M. Raaka, Elizabeth Geras-Raaka, Arthur Pope, Marvin C. Gershengorn, Rebecca S. Bahn, Susanne Neumann
Publikováno v:
Thyroid. 22:839-843
Fibroblasts (FIBs) within the retro-orbital space of patients with Graves' disease (GOFs) express thyrotropin receptors (TSHRs) and are thought to be an orbital target of TSHR-stimulating autoantibodies in Graves' ophthalmopathy (GO). Recently, we de
Publikováno v:
Pancreas. 38:197-202
Objectives: Thyrotropin-releasing hormone (TRH) is expressed in rodent and human adult pancreata and in mouse pancreas during embryonic development. However, expression of TRH receptors (TRHRs) in the pancreas is controversial. We sought to provide e
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Thyrotropin-releasing hormone (TRH) is a neuropeptide that initiates its effects in mice by interacting with two G protein-coupled receptors, TRH receptor type 1 (TRH-R1) and TRH receptor type 2 (TRH-R2). Two previous reports described the effects of
Autor:
Bruce M. Raaka, Chi Shing Sum, Irina G. Tikhonova, Marvin C. Gershengorn, Susanne Neumann, Stanislav Engel, Stefano Costanzi
Publikováno v:
Journal of Medicinal Chemistry. 51:625-633
The G-protein-coupled receptor free fatty acid receptor 1 (FFAR1), previously named GPR40, is a possible novel target for the treatment of type 2 diabetes. In an attempt to identify new ligands for this receptor, we performed virtual screening (VS) b
Autor:
Stefano Costanzi, Stanislav Engel, Marvin C. Gershengorn, Bruce M. Raaka, Anny-Odile Colson, Francesca Deflorian
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 71:783-794
Multiple computational methods have been employed in a comparative study of thyrotropin-releasing hormone receptors 1 and 2 (TRH-R1 and TRH-R2) to explore the structural bases for the different functional properties of these G protein-coupled recepto
Autor:
Laertis Ikonomou, Marvin C. Gershengorn, Behrous Davani, Elizabeth Geras-Raaka, Russell A. Morton, Bruce M. Raaka, Bernice Marcus-Samuels
Publikováno v:
Stem Cells. 25:3215-3222
Islet transplantation offers improved glucose homeostasis in diabetic patients, but transplantation of islets is limited by the supply of donor pancreases. Undifferentiated precursors hold promise for cell therapy because they can expand before diffe
Autor:
Malgorzata Wiench, Hanief M Shahjee, Matthew M. Rechler, Cem Elbi, Jiang Hong, Bruce M. Raaka, Klaus Pechhold, Nisan Bhattacharyya, Giovanna Zappalà
Publikováno v:
Journal of Biological Chemistry. 281:24588-24601
Insulin-like growth factor binding protein-3 (IGFBP-3), a secreted protein, has the intrinsic ability to induce apoptosis directly without binding insulin-like growth factors. Previous studies suggested that IGFBP-3 must be secreted to exert its biol