Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bruce M. Jarnot"'
Publikováno v:
Toxicology. 134:179-195
Perfluorodecanoic acid (PFDA) is a potent peroxisome proliferator that causes hepatotoxicity but lacks tumor-promoting activity in rats. We previously showed that a single dose of PFDA at 50 mg/kg (∼LD 50 ) causes an elevation in liver phosphocholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df4f75873fac61795ecfd546364df92
https://doi.org/10.1016/s0300-483x(99)00038-4
https://doi.org/10.1016/s0300-483x(99)00038-4
Publikováno v:
Chemical Research in Toxicology. 8:77-81
The perfluorinated carboxylic acid, perfluoro-n-decanoic acid (PFDA), is a known peroxisome proliferator which displays toxicity in rodents. Using a paired-tracer first-pass extraction technique, the effect of PFDA on hepatic glucose transport was de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace6da1419c3ef8cdd83b1004e8b7876
https://doi.org/10.1021/tx00043a010
https://doi.org/10.1021/tx00043a010
Autor:
Bruce M. Jarnot, Harvey J. Clewell
Publikováno v:
Risk Analysis. 14:265-276
Noncancer risk assessment traditionally relies on applied dose measures, such as concentration in inhaled air or in drinking water, to characterize no-effect levels or low-effect levels in animal experiments. Safety factors are then incorporated to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d542a572b992c49e24828bc73b77bca
https://doi.org/10.1111/j.1539-6924.1994.tb00241.x
https://doi.org/10.1111/j.1539-6924.1994.tb00241.x
Publikováno v:
Toxicology Letters. 71:69-75
Male Wistar rats and male Duncan Hartley guinea pigs were treated with one i.p. dose of perfluorodecanoic acid (PFDA) resulting in pronounced hepatomegaly in the rat but not the guinea pig. PFDA treatment also resulted in a 4-fold induction of lauric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e316b6008624fe8ca667a62eec81b279
https://doi.org/10.1016/0378-4274(94)90200-3
https://doi.org/10.1016/0378-4274(94)90200-3
Publikováno v:
Chemical Research in Toxicology. 5:512-519
Male Fischer-344 rats administered a single intraperitoneal dose of perfluoro-n-octanoic acid (PFOA) or perfluoro-n-decanoic acid (PFDA) display a similar "wasting toxicity" characteristic of perfluorocarboxylic acids, with marked differences in temp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bea2b1d79e859f7e33bf6803b27cbf7
https://doi.org/10.1021/tx00028a009
https://doi.org/10.1021/tx00028a009
Autor:
Bruce M. Jarnot, Marilyn E. George, G. Gordon Gibson, Edwin Chinje, Peter Kentish, Maria Jesus Diaz
Publikováno v:
Toxicology. 86(1-2)
The influence of a single dose of the peroxisome proliferator, perfluoro-n-octanoic acid (PFOA) on hepatic and renal mixed-function oxidase activities has been examined in rats. Peroxisome proliferation was confirmed by increases in peroxisomal palmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85149b472ac3c66b3817bcf194c7b2c1
https://pubmed.ncbi.nlm.nih.gov/8134918
https://pubmed.ncbi.nlm.nih.gov/8134918
Publikováno v:
Chemical research in toxicology. 7(1)
Carbon-13 NMR spectroscopy was used to study the effects of the peroxisome proliferator perfluoro-n-decanoic acid (PFDA) on hepatic carbohydrate metabolism in male Fischer-344 rats. The data indicate that PFDA-treated rats display an inhibition in he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972111a8aca9c5bd35e2376250aa4f48
https://pubmed.ncbi.nlm.nih.gov/8155820
https://pubmed.ncbi.nlm.nih.gov/8155820
Autor:
Bruce M. Jarnot, Catherine A. Taylor
Publikováno v:
Proceedings, annual meeting, Electron Microscopy Society of America. 51:396-397
Peroxisome induction can be expressed as an increase in peroxisome area (proliferation) or as an increase in peroxisomal fatty acid oxidation (activity). This study compares proliferation and activity as endpoints for hepatic peroxisome induction by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eba3d38cdfb00dcc1bd2c532bb281bdd
https://doi.org/10.1017/s0424820100147818
https://doi.org/10.1017/s0424820100147818
Publikováno v:
Clinical Immunology and Immunopathology. 49:187-203
Inbred Brown Norway (BN) rats treated with mercuric chloride develop autoantibodies to renal basement membranes and an immunologically mediated membranous glomerulonephritis. To date, this experimental rat model of chemically induced autoimmunity has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be15d46d64dff9aa2dfa66fb189d1df5
https://doi.org/10.1016/0090-1229(88)90109-2
https://doi.org/10.1016/0090-1229(88)90109-2
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