Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Bruce M. Fenton"'
Autor:
Bruce M. Fenton, Tanzy Love, Carl J. Johnston, Christina Reed, Jacob N. Finkelstein, Eric Hernady, Jacqueline P. Williams, Angela M. Groves
Publikováno v:
Radiation research. 190(5)
Biomarkers could play an essential role during triage in the aftermath of a radiological event, where exposure to radiation will be heterogeneous and complicated by concurrent trauma. Used alongside biodosimetry, biomarkers can identify victims in ne
Autor:
Scott F. Paoni, Bruce M. Fenton, Mesut Muyan, Kathryn Harper, Aja Kalkanoglu, Stephanie L. Nott, Ming Chen, Yanfang Huang
Publikováno v:
Molecular Medicine. 16:10-18
The main circulating estrogen hormone 17beta-estradiol (E2) contributes to the initiation and progression of breast cancer. Estrogen receptors (ERs), as transcription factors, mediate the effects of E2. Ablation of the circulating E2 and/or preventio
Autor:
Kunzhong Zhang, Chaomei Liu, Mei Zhang, Bruce M. Fenton, Weimin Sun, Wei Wang, Shanmin Yang, Peter C. Keng, Steven B. Zhang, Steven Swarts, Paul Okunieff, David James Maguire, Hengshan Zhang, Lurong Zhang
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 74:1592-1599
Purpose Current biodosimetric techniques for determining radiation exposure have inherent delays, as well as quantitation and interpretation limitations. We have identified a new technique with the advantage of directly measuring circulating DNA by a
Autor:
Bruce M. Fenton, Scott F. Paoni
Publikováno v:
Cancer Research. 67:9921-9928
Although antiangiogenic strategies have proven highly promising in preclinical studies and some recent clinical trials, generally only combinations with cytotoxic therapies have shown clinical effectiveness. An ongoing question has been whether conve
Autor:
Lisbeth A. Boule, Kelly Thevenet-Morrison, Todd A. Jusko, B. Paige Lawrence, Bruce M. Fenton, Catherine G. Burke
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 148(2)
Perinatal environmental exposures are potentially important contributors to the increase in autoimmune diseases. Yet, the mechanisms by which these exposures increase self-reactive immune responses later in life are poorly understood. Autoimmune dise
Autor:
Bruce M. Fenton, Lurong Zhang, Yanghua Yi, Wei Wang, Liangjie Yin, Ying Su, Paul Okunieff, Zhenyu Xiao, Shanmin Yang
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 65:882-889
Purpose: To investigate the effect of esculentoside A (EsA) on radiation-induced cutaneous and fibrovascular toxicity and its possible molecular mechanisms, both in vivo and in vitro . Methods and Materials: Mice received drug intervention 18 hours b
Publikováno v:
Medical Physics. 33:1623-1633
Ultrasound-induced blood stasis has been observed for more than 30 years . Most of the literature has been focused on the health risks associated with this phenomenon and methods employed to prevent stasis from occurring during ultrasound imaging. To
Publikováno v:
Cancer Research. 64:5712-5719
Although clinical trials of antiangiogenic strategies have been disappointing when administered as single agents, such approaches can play an important role in cancer treatment when combined with conventional therapies. Previous studies have shown th
Publikováno v:
Radiotherapy and Oncology. 72:221-230
Background and purpose The primary objectives of this study were to address two major questions. (1) Does VEGF receptor-2 antibody (DC101) produce detrimental effects on tumor vascular function and oxygenation that could compromise adjuvant therapies
Autor:
Jacob N. Finkelstein, Jacqueline P. Williams, Paul Okunieff, Christina Reed, Carl J. Johnston, Bruce M. Fenton, Eric Hernady
Publikováno v:
Radiation Research. 161:560-567
Our group's work on late radiation effects has been governed by the hypothesis that the effects observed in normal tissues are a consequence of multicellular interactions through a network of mediators. Further, we believe that inflammation is a nece