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Greater inhibition of platelet procoagulant activity by antibody-derived glycoprotein IIb-IIIa inhibitors than by peptide and peptidomimetic inhibitors

Autor: Harvey J. Weiss, Bruce Lages

Publikováno v: British Journal of Haematology. 113:65-71

Antibody-derived GPIIb–IIIa antagonists, such as the c7E3 Fab fragment abciximab, have been shown to inhibit platelet procoagulant activity as well as platelet aggregation. Whether low-molecular-weight peptide-derived and peptidomimetic antagonists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::922259ee0194ff1986aadca7c9d146ad
https://doi.org/10.1046/j.1365-2141.2001.02721.x

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Secreted Dense Granule Adenine Nucleotides Promote Calcium Influx and the Maintenance of Elevated Cytosolic Calcium Levels in Stimulated Human Platelets

Autor: Bruce Lages, Harvey J. Weiss

Publikováno v: Thrombosis and Haemostasis. 81:286-292

SummaryEvidence that secreted dense granule adenine nucleotides mediate part of the agonist-induced cytosolic calcium ([Ca2+]i) responses in human platelets was obtained from comparisons of fura-2-loaded platelets from normal subjects and from patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e844bd3b504b7c94c79a8f0b21caeeca
https://doi.org/10.1055/s-0037-1614459

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Platelet Prothrombinase Activity and Intracellular Calcium Responses in Patients With Storage Pool Deficiency, Glycoprotein IIb-IIIa Deficiency, or Impaired Platelet Coagulant Activity — A Comparison With Scott Syndrome

Autor: Bruce Lages, Harvey J. Weiss

Publikováno v: Blood. 89:1599-1611

The procoagulant activity of platelets induced by collagen, thrombin, and collagen plus thrombin, measured as their capacity to promote the conversion of prothrombin to thrombin in the presence of factors Va and Xa, was studied in patients with α, �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d99da31825b41d9a5a5251a54b4cf7
https://doi.org/10.1182/blood.v89.5.1599

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Platelet alpha granule deficiency associated with decreased P-selectin and selective impairment of thrombin-induced activation in a new patient with gray platelet syndrome (α-storage pool deficiency)

Autor: Ira I. Sussman, Deborah Coletti, Bruce Lages, Harvey J. Weiss, Shirley P. Levine

Publikováno v: Journal of Laboratory and Clinical Medicine. 129:364-375

We report studies on a new patient with gray platelet syndrome (GPS, alpha-storage pool deficiency). Her lifelong bleeding history is associated with platelet abnormalities characteristic of GPS including mild to moderate thrombocytopenia, a populati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49f0e15afc8c3592fd08d6bed1a1dbf
https://doi.org/10.1016/s0022-2143(97)90185-2

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Enhanced Increases in Cytosolic Ca2+ in ADP-Stimulated Platelets from Patients with Delta-Storage Pool Deficiency – A Possible Indicator of Interactions between Granule-Bound ADP and the Membrane ADP Receptor

Autor: Bruce Lages, Harvey J. Weiss

Publikováno v: Thrombosis and Haemostasis. 77:376-382

SummaryThe possible involvement of secreted platelet substances in agonist- induced [Ca2+]i increases was investigated by comparing these increases in aspirin-treated, fura-2-loaded normal platelets and platelets from patients with storage pool defic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5db9cbf91f59576fbe46e04417a6197a
https://doi.org/10.1055/s-0038-1655971

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Evidence for a role of glycoprotein IIb-IIIa, distinct from its ability to support aggregation, in platelet activation by ionophores in the presence of extracellular divalent cations

Autor: Harvey J. Weiss, Bruce Lages

Publikováno v: Blood. 83:2549-2559

Ionophore A23187-induced 14C-serotonin secretion and thromboxane B2(TxB2) formation were found to be absent in citrated platelet-rich plasma (PRP) from thrombasthenic subjects and in normal PRP treated with glycoprotein (GP) IIb-IIIa complex-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e46d234718c02e259306d15f5a0aed4
https://doi.org/10.1182/blood.v83.9.2549.2549

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Studies of thromboxane B2, platelet factor 4, and fibrinopeptide A in bleeding-time blood of patients deficient in von Willebrand factor, platelet glycoproteins Ib and IIb-IIIa, and storage granules

Autor: Harvey J. Weiss, Bruce Lages

Publikováno v: Blood. 82:481-490

The blood volumes and concentrations of thromboxane B2 (TxB2), platelet factor 4 (PF4), and fibrinopeptide A (FPA) were measured every 30 seconds in bleeding-time blood in normal subjects and in patients with idiopathic thrombocytopenic purpura (ITP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a372a0c442c80f678784bc5f29f5d66d
https://doi.org/10.1182/blood.v82.2.481.481

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Heterogeneous abnormalities of platelet dense granule ultrastructure in 20 patients with congenital storage pool deficiency

Autor: Lancy Y. Tsung, Bruce Lages, Harvey J. Weiss, William J. Vicic, James G. White

Publikováno v: British journal of haematology. 83(2)

Studies on platelet dense granule structure were carried out in 20 patients with various types of congenital storage pool deficiency (SPD), including 15 with specific deficiencies of dense granules and dense granule substances (delta-SPD), and five w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773d7bbbd246c64ff4be090bce73b98b
https://pubmed.ncbi.nlm.nih.gov/8457477

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