Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bruce L. Rogers"'
Autor:
Austin T O'Dea, Nathan L. Ponzar, John E. Tavis, Molly E Woodson, Bruce L Rogers, Daniel P Bradley, Ryan P. Murelli, Alaina Knier, Qilan Li
Publikováno v:
Antimicrob Agents Chemother
The α-hydroxytropolones (αHTs) are troponoid inhibitors of hepatitis B virus (HBV) replication that can target HBV RNase H with submicromolar efficacies. αHTs and related troponoids (tropones and tropolones) can be cytotoxic in cell lines as measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6696a7e64c277ee7f73da06f83f52f
https://europepmc.org/articles/PMC8765277/
https://europepmc.org/articles/PMC8765277/
Autor:
Timothy Leach, Bruce L. Rogers
Publikováno v:
Drug Discovery Today: Therapeutic Strategies. 1:513-517
Clostrium difficile, a Gram-positive, spore-forming anaerobic bacillus, is one of the most common causes of hospital-acquired diarrhea. The two most important risk factors for C. difficile-associated diarrhea (CDAD) are recent exposure to an antibiot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3882492fa9648ac37715d80e5f35d4b0
https://doi.org/10.1016/j.ddstr.2004.11.001
https://doi.org/10.1016/j.ddstr.2004.11.001
Publikováno v:
Journal of Allergy and Clinical Immunology. 95:1221-1228
Background: The major cat allergen Fel d I consists of two polypeptide chains linked by disulfide bonds, each of which has been expressed in bacteria. To investigate the antigenic structure of Fel d I, antibody binding to the native molecule and to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061a695e84c44c3c59abc5a93596ce06
https://doi.org/10.1016/s0091-6749(95)70079-x
https://doi.org/10.1016/s0091-6749(95)70079-x
Autor:
Sandra J. Craig, Anneliese K. Nault, Bruce L. Rogers, Christine B. Bizinkauskas, Debra B. Segal, Julian F. Bond, Thomas J. Briner, Kuo Mei-Chang, Annette M. Lussier, Thomas Luby, Jay P. Morgenstern, Garman Richard D, Catherine M. Counsell, Chen Meei-Song
Publikováno v:
Molecular Immunology. 31:955-966
The complete primary structure of Fel d I2 has been determined and shown to be comprised of two separate polypeptide chains (designated chain 1 and 2). Overlapping peptides covering the entire sequence of both chains of Fel d I have been used to map
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff988b76d4eef03072023fa56f9be80
https://doi.org/10.1016/0161-5890(94)90090-6
https://doi.org/10.1016/0161-5890(94)90090-6
Autor:
Bruce L. Rogers, Julian F. Bond, Debra B. Segal, Anneliese K. Nault, Kuo Mei-Chang, Andrew W. Brauer
Publikováno v:
Molecular Immunology. 30:1529-1541
To delineate the relationship between the structural conformation and the stability of an allergen and its antigenicity, we have chosen the major allergen from cat dander, Fel dI. From protein sequence analysis data we have examined the structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3361563e7abb4e9c32c430d297c15b9d
https://doi.org/10.1016/0161-5890(93)90461-j
https://doi.org/10.1016/0161-5890(93)90461-j
Publikováno v:
Molecular Immunology. 30:559-568
This study describes the properties of the two recombinantly expressed polypeptide chains of Fel d I, the major allergen produced by the domestic cat ( Felis domesticus ). An inframe linker encoding polyhistidine has been added to the 5' ends of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db12eeae921fa4bbd984a9307805b0cf
https://doi.org/10.1016/0161-5890(93)90030-f
https://doi.org/10.1016/0161-5890(93)90030-f
Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat
Autor:
Jay P. Morgenstern, Sandra J. Craig, Joanne Pollock, Xu-Bo Yu, Irwin J. Griffith, Bruce L. Rogers
Publikováno v:
Gene. 113:263-268
The genes encoding chain 1 (Ch1) and chain 2 (Ch2) of the major allergen of the domestic cat, Felis domesticus I, have been analyzed by genomic cloning and by polymerase chain reaction (PCR). Ch1 has two potential leader sequences, designated A and B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e35b387ecdb395ed8fe80c0de251397
https://doi.org/10.1016/0378-1119(92)90405-e
https://doi.org/10.1016/0378-1119(92)90405-e
Autor:
Bruce L, Rogers
Publikováno v:
Current opinion in drug discoverydevelopment. 7(2)
The unabated spread of drug-resistant bacterial pathogens continues to pose a significant threat to patient health. However, there are now several new and improved derivatives from established classes of antibiotics that have recently been approved o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2251bf4aa00700a4068bf90dca75173
https://pubmed.ncbi.nlm.nih.gov/15603255
https://pubmed.ncbi.nlm.nih.gov/15603255
T cells control the majority of antigen-specific immune responses. Therefore, influencing the activation of the T-cell response in order to modify immune responsiveness is an obvious therapeutic goal. We have used a mouse model of response to Fel d I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1ad988f20c559791da2702e7e3f8dd
https://europepmc.org/articles/PMC47191/
https://europepmc.org/articles/PMC47191/
Autor:
Bruce L. Rogers, Martin D. Chapman, Jay P. Morgenstern, Irwin J. Griffith, Andrew W. Brauer, Julian F. Bond, Kuo Mei-Chang
The complete primary structure of Fel dI (International Union of Immunological Societies nomenclature), the major allergen produced by the domestic cat, Felis domesticus, was determined by protein sequence analysis and cDNA cloning. Protein sequencin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdfb2a398eeb4c9644fd774a3ecb129
https://europepmc.org/articles/PMC52784/
https://europepmc.org/articles/PMC52784/