Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Bruce L. Roberts"'
Autor:
Satoru Morita, Takeshi Tanoue, Kozue Takeshita, Yutaka Kawakami, Ashwin N. Skelly, Hera Vlamakis, Jason M. Norman, Kenya Honda, Makoto Suematsu, Bernat Olle, Vanni Bucci, Tomonori Yaguchi, Takashi Inoue, Koji Atarashi, Masahira Hattori, Iori Motoo, Keiko Yasuma-Mitobe, Daniel Mucida, Seiko Narushima, Bruce L. Roberts, Dieter Riethmacher, Ramnik J. Xavier, Atsushi Shiota, Damian R. Plichta, Yuki Sugiura, Wataru Suda, Kayoko Sugita, Tsuneyasu Kaisho
Publikováno v:
Nature. 565:600-605
There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24172d126eb8411e44ff097369b5c2a6
https://doi.org/10.1038/s41586-019-0878-z
https://doi.org/10.1038/s41586-019-0878-z
Autor:
Sambasiva P Rao, Jose Sancho, Juanita Campos-Rivera, Paula M Boutin, Peter B Severy, Timothy Weeden, Srinivas Shankara, Bruce L Roberts, Johanne M Kaplan
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39416 (2012)
Alemtuzumab is a monoclonal antibody that targets cell surface CD52 and is effective in depleting lymphocytes by cytolytic effects in vivo. Although the cytolytic effects of alemtuzumab are dependent on the density of CD52 antigen on cells, there is
Externí odkaz:
https://doaj.org/article/5deecdc8b16d435480f9c85d5a9e76d0
Autor:
Amit Reddy, Arthur E. Frankel, Bruce L. Roberts, Maureen Hayes, Andrew Y. Koh, John Lightcap, Sachin Kumar Deshmukh, Brooks D. Rabideau, Steven McClellan, T. Grant Glover, Seema Singh
Publikováno v:
Integrative Cancer Therapies, Vol 18 (2019)
Integrative Cancer Therapies
Integrative Cancer Therapies
The past decade has seen tremendous advances in both our understanding of cancer immunosuppressive microenvironments and colonic bacteria facilitated by immune checkpoint inhibitor antibodies and next generation sequencing, respectively. Because an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9298e7720416367d3c798343b0b39b77
https://doaj.org/article/aad2bd1ca75c42c481cbc7b4e261abbb
https://doaj.org/article/aad2bd1ca75c42c481cbc7b4e261abbb
Autor:
Jason M. Norman, Bruce L. Roberts, Judy Wang, Diwakar Davar, Michael Cecchini, Zev A. Wainberg, Bernat Olle, Anita Ahmed Turk, Dmitri Bobilev, Rose L. Szabady, Martin Gutierrez
Publikováno v:
Cancer Research. 80:CT246-CT246
Background: Gut microbiome composition affects response to PD-1 blockade; and recent proof of concept studies suggest that gut microbiome manipulation is effective in reversing resistance to PD-1 blockade. VE800 is an oral live biotherapeutic consist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dd8c421835f203e8db75a18fab25ffe
https://doi.org/10.1158/1538-7445.am2020-ct246
https://doi.org/10.1158/1538-7445.am2020-ct246
Autor:
Melissa Dsouza, Jessica S. Schneider, Bruce L. Roberts, Dmitri Bobilev, Brian Klein, Vanni Bucci, Jason M. Norman, Bernat Olle, Shilpa P. Reddy
Publikováno v:
Gastroenterology. 158:S-15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc452a451c8ad25a5372bb19f5fa4ecb
https://doi.org/10.1016/s0016-5085(20)30718-6
https://doi.org/10.1016/s0016-5085(20)30718-6
Autor:
Steve McClellan, Kenya Honda, Johnny Lightcap, Amit Reddy, Andrew Y. Koh, Arthur E. Frankel, Rose L. Szabady, Bruce L. Roberts, Sachin Kumar Deshmukh
Publikováno v:
Journal of Clinical Oncology. 37:e14195-e14195
e14195 Background: Immune checkpoint inhibitor therapy, ICT, achieves remissions in melanoma patients but factors modulating response are not well defined. Our group (Frankel et al. Neoplasia 2017) and others have identified specific gut microbiota a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60a20476b0733316cbbb47b5aa2df9fe
https://doi.org/10.1200/jco.2019.37.15_suppl.e14195
https://doi.org/10.1200/jco.2019.37.15_suppl.e14195
Autor:
Lou Vaickus, Dmitri Bobilev, Paolo DePetrillo, Jason M. Norman, Shilpa Reddy, Brian Klein, Bernat Olle, Bruce L. Roberts
Publikováno v:
Gastroenterology. 156:S-899
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38b2d92183c93940f7825203c59f8cdd
https://doi.org/10.1016/s0016-5085(19)39218-2
https://doi.org/10.1016/s0016-5085(19)39218-2
Autor:
Johanne Kaplan, William M. Siders, Evis Havari, Tri-Hung Nguyen, Michael J. Turner, Srinivas Shankara, Bruce L. Roberts, Juanita Campos-Rivera
Publikováno v:
Immunology. 141:123-131
Alemtuzumab is a humanized monoclonal antibody specific for the CD52 protein present at high levels on the surface of B and T lymphocytes. In clinical trials, alemtuzumab has shown a clinical benefit superior to that of interferon-β in relapsing-rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5358e7811dab3cf815ccff2532ed9c01
https://doi.org/10.1111/imm.12178
https://doi.org/10.1111/imm.12178
Autor:
William M. Siders, Srinivas Shankara, Jacqueline Shields, Paula Boutin, Carrie Garron, Johanne Kaplan, Yanping Hu, William Weber, Bruce L. Roberts
Publikováno v:
Leukemia & Lymphoma. 51:1293-1304
Alemtuzumab is a recombinant humanized IgG1 monoclonal antibody directed against CD52, an antigen expressed on the surface of normal and malignant B and T lymphocytes. Alemtuzumab is approved for the treatment of B-cell chronic lymphocytic leukemia (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045e465a02f9b8518e4d3e2cda4665e3
https://doi.org/10.3109/10428191003777963
https://doi.org/10.3109/10428191003777963
Autor:
William Weber, Nakayuki Honma, Paula Boutin, Cecile Rouleau, Srinivas Shankara, Rebecca G. Bagley, Beverly A. Teicher, Shiro Kataoka, Bruce L. Roberts, Isao Ishida
Publikováno v:
Microvascular Research. 76:180-188
The formation of functional, mature blood vessels depends on the interaction between endothelial cells and pericytes. Commonality exists in the processes involved in vasculature development between tissues whether healthy or diseased. Endosialin/TEM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93245529c1da736bcd5b4102d7f781e
https://doi.org/10.1016/j.mvr.2008.07.008
https://doi.org/10.1016/j.mvr.2008.07.008