Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bruce L. Jacobson"'
Autor:
Ann Greer, Stoffan Karen M, Joan M. Carboni, Bruce L. Jacobson, Zoeckler Mary Edson, Marco M. Gottardis, Dolatrai M. Vyas, Ricardo M. Attar, Aixin Li, Steven Hansel, Subramaniam Krishnanathan, Mark D. Wittman, Pieying Liu, Chiehying Chang, Yax Sun, Upender Velaparthi, Balu Balasubramanian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:974-977
A novel class of 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase is described. This report discusses the SAR of 4-(2-hydroxy-2-phenylethylamino)-substituted pyridones with improved IGF-1R potency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c951ab3913e0e3f58e4cf105cfa4a1d4
https://doi.org/10.1016/j.bmcl.2006.11.041
https://doi.org/10.1016/j.bmcl.2006.11.041
Autor:
Joseph J. Villafranca, Bruce L. Jacobson, John J. Emanuele, Chiehying Y. Chang, Howard Einspahr, Haiyong Jin
Publikováno v:
Protein Science. 5:2566-2574
Uridine diphosphate-N-acetylmuramate:L-alanine ligase (EC 6.3.2.8, UNAM:L-Ala ligase or MurC gene product) catalyzes the ATP-dependent ligation of the first amino acid to the sugar moiety of the peptidoglycan precursor. This is an essential step in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476fa70b91f8c7fd036a86e490f0e77a
https://doi.org/10.1002/pro.5560051219
https://doi.org/10.1002/pro.5560051219
Autor:
John L. Markley, Young Kee Chae, Gordon Tollin, Lars Skjeldal, John K. Hurley, Hazel M. Holden, Byung-Ha Oh, Hong Cheng, Bruce L. Jacobson, Bin Xia
Publikováno v:
Journal of Bioenergetics and Biomembranes. 26:67-88
The ability to overexpress [2Fe-2S] ferredoxins in Escherichia coli has opened up exciting research opportunities. High-resolution x-ray structures have been determined for the wild-type ferredoxins produced by the vegatative and heterocyst forms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec0cb5bf2530cfd531fbe1df1565b8f
https://doi.org/10.1007/bf00763220
https://doi.org/10.1007/bf00763220
Publikováno v:
Biochemistry. 32:6788-6793
The [2Fe-2S] ferredoxin produced in the heterocyst cells of Anabaena 7120 plays a key role in nitrogen fixation, where it serves as an electron acceptor from various sources and an electron donor to nitrogenase. The three-dimensional structure of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a2fb76de0ca6dfba8f5019899e0ff7
https://doi.org/10.1021/bi00077a033
https://doi.org/10.1021/bi00077a033
Autor:
Andrzej M. Krezel, William M. Westler, Ivan Rayment, Lars Skjeldal, John L. Markley, Bruce L. Jacobson, Hazel M. Holden, Byung-Ha Oh
Publikováno v:
Biochemistry. 30:7363-7368
Hyperfine 1H NMR signals of the 2Fe-2S* vegetative ferredoxin from Anabaena 7120 have been studied by two-dimensional (2D) magnetization exchange spectroscopy. The rapid longitudinal relaxation rates of these signals required the use of very short nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496263bd766ac8193ed460288a290c5c
https://doi.org/10.1021/bi00244a002
https://doi.org/10.1021/bi00244a002
Autor:
Christian Betzel, Punit Kaur, Bruce L. Jacobson, Howard Einspahr, Tej Singh, Chiehying Chang, William A. Slusarchyk, Manashi Sherawat, Gregory S. Bisacchi, Markus Perbandt
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 63(Pt 4)
The structure of the complex formed between bovine beta-trypsin and the highly potent synthetic inhibitor 2-{3'-[5'-methoxy-2'-(N-p-diaminomethylphenyl)amido]-1'-pyrido}-5-(N-2''-t-butylethanol)amidobenzoic acid (C(28)H(32)N(5)O(6)) has been determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b0786cc508256152cc0803834e319e
https://pubmed.ncbi.nlm.nih.gov/17372355
https://pubmed.ncbi.nlm.nih.gov/17372355
Autor:
Bruce L. Jacobson, James C. Sutton, Malcolm E. Davis, Robert Zahler, Arvind Mathur, Karen S. Hartl, William A. Slusarchyk, Scott A. Bolton, Gregory S. Bisacchi, Steven M. Seiler, Martin L. Ogletree
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(9)
A series of nonguanidine N1-activated C4-carboxy azetidinone tryptase inhibitors was prepared by solid-phase methodology to quickly assess the SAR associated with distal functionality on the N1-activating group. From these studies, potent inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e2329aabf45d6e63d4067a08c43f9e
https://pubmed.ncbi.nlm.nih.gov/15081015
https://pubmed.ncbi.nlm.nih.gov/15081015
Publikováno v:
Archives of Biochemistry and Biophysics. 294:279-281
The [2Fe-2S] ferredoxin produced in the heterocyst cells of Anabaena 7120 plays a key role in nitrogen fixation, where it serves as an electron acceptor from various sources and an electron donor to nitrogenase. Crystals of recombinant heterocyst fer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a80a56063e5bc66f88d99410b65bf3
https://doi.org/10.1016/0003-9861(92)90169-w
https://doi.org/10.1016/0003-9861(92)90169-w
Publikováno v:
Biochemistry. 33(41)
The three-dimensional structure of the fatty-acid-binding protein isolated from the flight muscle of the desert locust Schistocerca gregaria has been solved and refined to a crystallographic R-value of 18.5% for all measured X-ray data from 30.0- to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0e193cc6eadfbe1dcb1067aa6426b7
https://pubmed.ncbi.nlm.nih.gov/7918460
https://pubmed.ncbi.nlm.nih.gov/7918460
Autor:
Florante A. Quiocho, Bruce L. Jacobson
Publikováno v:
Journal of Molecular Biology. 204:783-787
We have determined the effect of pH on the binding affinities of the conjugate bases of four different tetrahedral oxyacids to the sulfate-binding protein. The equilibrium dissociation constants of the binding of sulfate ( K d = 0.12 μm ) and selena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35618b7f3374dec12f5536d29f4e1ab5
https://doi.org/10.1016/0022-2836(88)90369-5
https://doi.org/10.1016/0022-2836(88)90369-5