Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Bruce L Homer"'
Autor:
Ken Dower, Shanrong Zhao, Franklin J Schlerman, Leigh Savary, Gabriela Campanholle, Bryce G Johnson, Li Xi, Vuong Nguyen, Yutian Zhan, Matthew P Lech, Ju Wang, Qing Nie, Morten A Karsdal, Federica Genovese, Germaine Boucher, Thomas P Brown, Baohong Zhang, Bruce L Homer, Robert V Martinez
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181861 (2017)
ZSF1 rats exhibit spontaneous nephropathy secondary to obesity, hypertension, and diabetes, and have gained interest as a model system with potentially high translational value to progressive human disease. To thoroughly characterize this model, and
Externí odkaz:
https://doaj.org/article/c8649b6e74a94a41b0cb26d57a6ac938
Autor:
Julia H Shin, Steven A. Gilbert, Vikram R. Rao, Betsy J. Barnes, Lih-Ling Lin, Ken Dower, Virginia Pascual, Bruce A. Jacobson, Iain Kilty, Jean J Beebe, Tatyana Andreyeva, Bruce L. Homer, Joanne Brodfuehrer, Weiyong Sun, Martin Hegen, Simeon Ramsey, M Nusrat Sharif, Margaret Fleming, Mera Tilley, Heng Liu, Aaron Winkler, Aiping Jiao, Saurav De, Shruti Athale, Peter T. Symanowicz, Ju Wang, Spencer I. Danto
Publikováno v:
Arthritis & Rheumatology. 73:2206-2218
Objective To investigate the role of PF-06650833, a highly potent and selective small-molecule inhibitor of interleukin-1-associated kinase 4 (IRAK4), in autoimmune pathophysiology in vitro, in vivo, and in the clinical setting. Methods Rheumatoid ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea4d3ef98a73e9f525a4ce2b040208a
https://doi.org/10.1002/art.41953
https://doi.org/10.1002/art.41953
Autor:
Bruce L, Homer, Ken, Dower
Publikováno v:
Toxicologic pathology. 46(8)
This symposium synopsis summarizes key results from a 41-week study of diabetic nephropathy (DN) in the type 2 diabetic ZSF1 fa/fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aeafab50fab725256bc1e8c00f2db596
https://pubmed.ncbi.nlm.nih.gov/30278832
https://pubmed.ncbi.nlm.nih.gov/30278832
Autor:
Baohong Zhang, Franklin J. Schlerman, Matthew P. Lech, Leigh Savary, Morten A. Karsdal, Bruce L. Homer, Thomas P. Brown, Gabriela Campanholle, Ju Wang, Ken Dower, Qing Nie, Germaine Boucher, Shanrong Zhao, Bryce G. Johnson, Federica Genovese, Li Xi, Yutian Zhan, Robert V. Martinez, Vuong Nguyen
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181861 (2017)
PLoS ONE
PLoS ONE
ZSF1 rats exhibit spontaneous nephropathy secondary to obesity, hypertension, and diabetes, and have gained interest as a model system with potentially high translational value to progressive human disease. To thoroughly characterize this model, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e277265c5cbe0c5ccea9b86987f25e0
http://europepmc.org/articles/PMC5529026?pdf=render
http://europepmc.org/articles/PMC5529026?pdf=render
Autor:
Bruce L. Homer, Catharine J. Andresen, Daniel Morton, James A. Warneke, Dale L. Morris, Cedo M. Bagi, Michael A. Tones, Laurence O. Whiteley
Publikováno v:
Toxicologic Pathology. 43:411-423
Orally administered small molecule agonists of soluble guanylate cyclase (sGC) induced increased numbers of osteoclasts, multifocal bone resorption, increased porosity, and new bone formation in the appendicular and axial skeleton of Sprague-Dawley r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564b97e00d4be26323006d8bd252c650
https://doi.org/10.1177/0192623314546559
https://doi.org/10.1177/0192623314546559
Autor:
Ken Dower, Bruce L. Homer
Publikováno v:
Toxicologic Pathology. 46:976-977
This symposium synopsis summarizes key results from a 41-week study of diabetic nephropathy (DN) in the type 2 diabetic ZSF1 fa/faCP rat model. During this study, we conducted longitudinal analysis of biomarkers, renal histopathology, ultrastructural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::923a78778af2e49896bb28f8539de0f1
https://doi.org/10.1177/0192623318803278
https://doi.org/10.1177/0192623318803278
Autor:
Bruce L. Homer, Shashi K. Ramaiah, Sean Keegan, Cheryl Nickerson-Nutter, Joy S. Miyashiro, Stephen E. Benoit, Tatyana Andreyeva, Jameel Syed, Nagappan Mathialagan, Shashi Mohan, Nancy L. Wood, Jason Edmonds, Mark E. Schnute, Andrew L. Rankin, Elena Peeva, Yutian Zhan, Kyri Dunussi-Joannopoulos, Dean Messing, Timothy A. Cook, Micah J. Benson, John Douhan, Nilufer P. Seth
Publikováno v:
The Journal of Immunology. 191:4540-4550
Autoantibody production and immune complex deposition within the kidney promote renal disease in patients with lupus nephritis. Thus, therapeutics that inhibit these pathways may be efficacious in the treatment of systemic lupus erythematosus. Bruton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d254f70707f6dc81ca363e845e897d96
https://doi.org/10.4049/jimmunol.1301553
https://doi.org/10.4049/jimmunol.1301553
Autor:
Shawn P. O'Neil, Gabriela Campanholle, Eva E. Nagiec, Bruce L. Homer, Lih-Ling Lin, Hendrik Neubert, Karrie A. Brenneman, Ju Wang, Margaret Fleming, Steven Evans, Riyez Karim, Yutian Zhan, Priya S. Chockalingam, Nicholas Pullen, M Nusrat Sharif, Jameel Syed
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155368 (2016)
PLoS ONE
PLoS ONE
The cytokine TWEAK and its cognate receptor Fn14 are members of the TNF/TNFR superfamily and are upregulated in tissue injury to mediate local tissue responses including inflammation and tissue remodeling. We found that in various models of kidney di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93f29ba883c9222ec9827c569a3677d
http://europepmc.org/articles/PMC4865213?pdf=render
http://europepmc.org/articles/PMC4865213?pdf=render
Autor:
Rounak Nassirpour, Laurence O. Whiteley, Deborah C. Carraher, Zhonghan Li, James A. Warneke, Shawn P. O'Neil, Karen Percival, Thomas A. Brown, Steven Bailey, Sachin Mathur, Yizheng Li, Bruce L. Homer
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 148(1)
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate protein levels posttranscriptionally. miRNAs play important regulatory roles in many cellular processes and have been implicated in several diseases. Recent studies have reported significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa983825afdf0ef676e52787fae670ec
https://pubmed.ncbi.nlm.nih.gov/26253709
https://pubmed.ncbi.nlm.nih.gov/26253709
Autor:
Sadie S. Coberley, Nancy J. Szabo, Ruth Y. Ewing, Ellis C. Greiner, Jan H. Landsberg, Leanne J. Flewelling, Corinne Rose, Charles A. Manire, Francesco C. Origgi, Allen M. Foley, Andrew P. Mizisin, Bruce L. Homer, Susan A. Schaf, Elliott R. Jacobson, Glenn R. Harman, Nancy Mettee, Cheryl L. Chrisman, Brian A. Stacy, Richie Moretti, G. Diane Shelton, Douglas R. Mader
Publikováno v:
Diseases of Aquatic Organisms. 70:139-154
Beginning in October 2000, subadult loggerhead sea turtles Caretta caretta showing clinical signs of a neurological disorder were found in waters off south Florida, USA. Histopathology indicated generalized and neurologic spirorchiidiasis. In loggerh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35dde53436dea1d598db136dc087a4b3
https://doi.org/10.3354/dao070139
https://doi.org/10.3354/dao070139