Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Bruce L, Patton"'
Publikováno v:
Channels, Vol 18, Iss 1 (2024)
KATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassium channel
Externí odkaz:
https://doaj.org/article/ae5b90c7be9645178e9ac3531c0fa733
Publikováno v:
Current Opinion in Structural Biology. 79:102541
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48714c32dd07e0a534b04e90a16f5033
https://doi.org/10.1016/j.sbi.2023.102541
https://doi.org/10.1016/j.sbi.2023.102541
Autor:
Min Woo, Sung, Camden M, Driggers, Barmak, Mostofian, John D, Russo, Bruce L, Patton, Daniel M, Zuckerman, Show-Ling, Shyng
Publikováno v:
Journal of molecular biology. 434(19)
Regulation of pancreatic K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9cc5f45cb38c5e98c6760f73541f11a
https://pubmed.ncbi.nlm.nih.gov/35964676
https://pubmed.ncbi.nlm.nih.gov/35964676
Autor:
Min Woo Sung, Camden M. Driggers, Barmak Mostofian, John D. Russo, Bruce L. Patton, Daniel M. Zuckerman, Show-Ling Shyng
Regulation of pancreatic KATP channels involves orchestrated interactions of channel subunits, Kir6.2 and SUR1, and their ligands. How ligand interactions affect channel conformations and activity is not well understood. To elucidate the structural c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17a792dec3b0739feac61c46c2da992f
https://doi.org/10.1101/2022.03.02.482692
https://doi.org/10.1101/2022.03.02.482692
Autor:
Zhongying Yang, Bruce L. Patton, Min Woo Sung, Camden M. Driggers, Daniel M. Zuckerman, John D. Russo, Show-Ling Shyng, Barmak Mostofian
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Vascular tone is dependent on smooth muscle KATP channels comprising pore-forming Kir6.1 and regulatory SUR2B subunits, in which mutations cause Cantu syndrome. Unique among KATP isoforms, they lack spontaneous activity and require Mg-nucleotides for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e5c2baa176883a135e9c99c50e9c02
https://doi.org/10.1073/pnas.2109441118
https://doi.org/10.1073/pnas.2109441118
Autor:
Min Woo, Sung, Zhongying, Yang, Camden M, Driggers, Bruce L, Patton, Barmak, Mostofian, John D, Russo, Daniel M, Zuckerman, Show-Ling, Shyng
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Vascular KATP channels formed by the potassium channel Kir6.1 and its regulatory protein SUR2B maintain blood pressure in the physiological range. Overactivity of the channel due to genetic mutations in either Kir6.1 or SUR2B causes seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f3c04b162c7a691b00a0e0fe9ac3075
https://pubmed.ncbi.nlm.nih.gov/34711681
https://pubmed.ncbi.nlm.nih.gov/34711681
Autor:
Barmak Mostofian, Show-Ling Shyng, Min Woo Sung, Zhongying Yang, Daniel M. Zuckerman, Bruce L. Patton, John D. Russo
Vascular tone is dependent on smooth muscle KATP channels comprising pore-forming Kir6.1 and regulatory SUR2B subunits, in which mutations cause Cantú syndrome. Unique among KATP isoforms, they lack spontaneous activity and require Mg-nucleotides fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1b8e5a5b85645c06d165f81a43fc891
https://doi.org/10.1101/2021.05.15.444267
https://doi.org/10.1101/2021.05.15.444267
Publikováno v:
Glia. 65:804-816
Neuropathy target esterase (NTE) or patatin-like phospholipase domain containing 6 (PNPLA6) was first linked with a neuropathy occurring after organophosphate poisoning and was later also found to cause complex syndromes when mutated, which can inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7574787276165f56048adb0209931d10
https://doi.org/10.1002/glia.23127
https://doi.org/10.1002/glia.23127
Publikováno v:
Glia. 65(5)
Neuropathy Target Esterase (NTE) or patatin-like phospholipase domain containing 6 (PNPLA6) was first linked with a neuropathy occurring after organophosphate poisoning and was later also found to cause complex syndromes when mutated, which can inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::222dfe575a873ce5dae604b649934015
https://pubmed.ncbi.nlm.nih.gov/28206686
https://pubmed.ncbi.nlm.nih.gov/28206686
Publikováno v:
The American Journal of Pathology. 176:839-849
Each extracellular matrix compartment in the kidney has a unique composition, with regional specificity in the expression of various laminin isoforms. Although null mutations in the majority of laminin chains lead to specific developmental abnormalit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d5854717f3546fb08f8133d685e9d1
https://doi.org/10.2353/ajpath.2010.090570
https://doi.org/10.2353/ajpath.2010.090570